Apical periodontitis is an inflammatory disease of microbial etiology. It has been suggested that endodontic bacterial DNA might translocate to distant organs via blood vessels, but no studies have conducted. We aimed first explore overall extraradicular infection, as well specifically by Porphyromonas spp; and their potential from infected root canals through peripheral mononuclear cells. In this cross-sectional study, healthy individuals with without a diagnosis apical associated lesion...

Introducción: Las enfermedades no transmisibles (ENT) son una carga importante en la mortalidad mundial. Se hipotetiza que asociación entre periodontitis y las ENT podría ser bidireccional. Objetivos: determinar prevalencia de (ENTs) individuos chilenos padecen periodontitis, estratificándolos acuerdo a severidad su condición periodontal. Métodos: Estudio cuantitativo, observacional, transversal. incluyeron pacientes inscritos Clínica Periodoncia Universidad Andrés Bello. analizaron fichas...

Introduction: Potentially inappropriate medication is associated with adverse health and functional outcomes, as well increased care costs.Objective: To estimate the prevalence types of potentially according to Beers criteria in community-dwelling older persons identify major clinical consequences during two years following.Materials methods: We conducted a longitudinal, descriptive, observational study that included 400 65-year or people (48% women) selected by simple random sampling 2012....

Introduction Apical periodontitis (AP) is a common oral disease caused by the inflammatory destruction of periapical tissues due to infection root canal system tooth. It also contributes systemic bacterial translocation, where peripheric mononuclear blood cells (PBMCs) can act as carriers. Toll-like receptor (TLR) 2 mediates response and activates responses. DNA methylation be induced bacteria modulation this response. Despite evidence that supports participation PBMCs in immune-inflammatory...

Abstract Aim To determine the systemic inflammatory burden, including hsCRP and its monomeric forms, in patients with apical lesions of endodontic origin treated root canal treatment (RCT). Methodology Prospective pre‐/post‐study. Apical periodontitis (AP) individuals aged 16–40 were included ( N = 29). Individuals received RCT followed at 1 6 months. Fasting blood samples obtained. (ALEO) diameter (mm), periapical index (PAI), recorded. The serum concentrations total determined by...

The use of artificial intelligence algorithms (AI) has gained importance for dental applications in recent years. Analyzing using IA information from different sensor data such as images or X-ray radiographs can help to improve medical decisions and achieve early diagnosis pathologies. In particular, the deep learning (DL) techniques based on convolutional neural networks (CNNs) obtained promising results images, which approaches classification, detection, segmentation are being studied with...

The use of artificial intelligence algorithms (AI) has gained importance for dental applications in recent years. Analyzing AI information from different sensor data such as images or panoramic radiographs (panoramic X-rays) can help to improve medical decisions and achieve early diagnosis pathologies. In particular, the deep learning (DL) techniques based on convolutional neural networks (CNNs) obtained promising results images, which approaches classification, detection, segmentation are...

Abstract Background Encapsulation of Porphyromonas gingivalis has been demonstrated as responsible several host immunological changes, which have associated with the pathogenesis periodontitis. Using a murine model periodontitis and two isogenic non‐capsulated mutants P. , this study aimed to analyze whether encapsulation induces more severe alveolar bone resorption, loss is T‐helper (Th)1 Th17‐pattern immune response. Methods Experimental periodontal infections were generated by oral...

Angiogenesis contributes to the development of apical periodontitis, and other oral pathologies; however, it remains unclear how this process is triggered. The aim was evaluate whether lipopolysaccharide (LPS) from Porphyromonas endodontalis gingivalis induced angiogenesis-related effects in vitro via TLR2 TLR4.Porphyromonas LPS (ATCC 35406 clinical isolate) purified with TRIzol, whereas P. obtained commercially. different (24 h) endothelial cell migration were analysed by Transwell assays,...

Apical periodontitis (AP) is the chronic inflammation of periradicular tissues in response to root canal infection. Whilst AP has been linked with systemic and noncommunicable diseases, its potential association nonalcoholic fatty liver disease (NAFLD) unknown. We aimed evaluate serum alanine aminotransferase (ALT) aspartate (AST) levels as surrogate markers hepatic injury, inflammatory burden otherwise healthy individuals without diagnosis.

Abstract Aim Epigenetic regulation of the key inflammatory genes plays a crucial role in controlling monocyte/macrophage‐mediated local and systemic responses to bacterial challenges. However, it has not been addressed apical periodontitis (AP). We aimed explore methylation pattern TNF‐α gene promoter its association with phenotype peripheral blood monocytes from individuals AP controls. Methods A cross‐sectional study was conducted, including otherwise healthy ( n = 25) controls 29)....

Background: Collecting duct carcinoma of the kidney (CDC) is a rare cancer associated with bad prognosis and, at present, no specific effective therapies. Case Report: We report clinical case disseminated highgrade CDC presenting widespread metastasis to both lungs, pelvic bones, axial skeleton, and central nervous system (posterior fossa, hemispheres pituitary-hypothalamic). The primary tumor in was demonstrated (by fluorescence situ hybridization immunohistochemistry Herceptest (3+ score))...

Introduction: J. Communi sberry is a high antioxidant fruit which used in several traditional medicinal systems to treat variety of diseases including rheumatism, arthritis and gout.This study was undertaken examine the inhibitory activity communis berry extracts on growth bacteria associated with autoimmune inflammatory disease, test their ability block CaCo2 HeLa cancer cell proliferation. Methods: Communis solvent were preparedusing solvents varying polarity. The investigated by disc...

Psoriasis and periodontitis are immunologically mediated chronic inflammatory diseases. Epidemiologic evidence has linked both; however, the change of markers in gingival crevicular fluid been poorly evaluated.To evaluate levels IL-17A, IL-22, IL-23, S100A7, S100A8, S100A9 psoriatic healthy subjects with without their relations to psoriasis severity.Cross-sectional study. Sample comprised following groups: controls or mild (n=21), moderate severe (n=18), individuals (n=11), (n=32). Levels...

To determine the methylation pattern of TLR2 gene promoter and its association with transcriptional regulation periapical inflammatory angiogenic responses in symptomatic asymptomatic forms apical periodontitis.In this cross-sectional study, lesions were obtained from volunteers periodontitis (AAP) (n = 17) (SAP) scheduled for tooth extraction, both total RNA DNA extracted. was bisulfite-treated, a region CpG island within amplified by qPCR products sequenced. Additionally, mRNA expression...

To determine the prescribing patterns for proton pump inhibitors and to estimate economic cost of their use in a group patients affiliated with Colombian Health System.This is descriptive observational study. Data analysis consisted prescriptions dispensed between October 1st, 2010 31st, were collected from systematic database 4.2 million members. Socio-demographic variables considered along defined daily dose,comedication, convenience indication inhibitor costs.In this study, 113,560 89...

Atopic dermatitis (AD) is a protease-modulated chronic disorder with heterogenous clinical manifestations which may lead to an imprecise diagnosis. To date, there are no diagnostic protease tests for AD. We explored the gingival crevicular fluid (GCF) profile of individuals moderate/severe AD compared healthy controls. An exploratory case-control study was conducted. patients (n = 23) and controls 21) were enrolled at International Center Clinical Studies, Santiago, Chile. Complete...

Apical Lesions of Endodontic Origin (ALEO) are initiated by polymicrobial endodontic canal infection. Porphyromonas gingivalis (Pg) and endodontalis (Pe) lipopolysaccharides (LPS) can induce a pro-inflammatory macrophage response through their recognition TLR2 TLR4. However, polarization responses induced Pg and/or Pe LPS in macrophages not fully understood. We aimed to characterize the profiles differentiated from THP-1 cells following stimulation reference strain clinical isolates. A...

Background: Oral cancer is the 15th most common cause of death in world. In Chile, 1% all deaths are related to oral and pharyngeal cancer.