A5080516250- Hormonal and reproductive studies
- Sexual function and dysfunction studies
- Sexual Differentiation and Disorders
- Urinary Bladder and Prostate Research
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Testicular diseases and treatments
- Urological Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Galectins and Cancer Biology
- Genital Health and Disease
- Kruppel-like factors research
- Renal cell carcinoma treatment
- Male Reproductive Health Studies
- Bladder and Urothelial Cancer Treatments
- Kidney Stones and Urolithiasis Treatments
- Genetic Syndromes and Imprinting
- Stress Responses and Cortisol
- Hormonal Regulation and Hypertension
- Pelvic floor disorders treatments
- Ureteral procedures and complications
- Glycosylation and Glycoproteins Research
- Adrenal and Paraganglionic Tumors
- Nail Diseases and Treatments
- Scoliosis diagnosis and treatment
University of Buenos Aires
2008-2024
Hospital de Clínicas "José de San Martín"
2003-2024
Bambino Gesù Children's Hospital
2019
Istituto Giannina Gaslini
2017
Hospital Alemán
2001-2016
Hospital de Clínicas
2014
Consejo Nacional de Investigaciones Científicas y Técnicas
2012
Instituto de Química y Fisicoquímica Biológicas
2012
Experimental Medicine and Biology Institute
2012
Inserm
2012
Galectins, a family of glycan-binding proteins, influence tumor progression by modulating interactions between tumor, endothelial, stromal, and immune cells. Despite considerable progress in identifying the roles individual galectins biology, an integrated portrait galectin network different microenvironments is still missing. We undertook this study to analyze "galectin signature" human prostate cancer microenvironment with overarching goal selecting novel-molecular targets for prognostic...
The role of oxidative stress in prostate cancer has been increasingly recognised. Acute and chronic inflammations generate reactive oxygen species that result damage to cellular structures. Haeme oxygenase-1 (HO-1) cytoprotective effects against damage. We hypothesise modulation HO-1 expression may be involved the process carcinogenesis progression. thus studied localisation 85 samples organ-confined primary obtained via radical prostatectomy (Gleason grades 4–9) 39 specimens benign...
Background/Aims: Adipose microenvironment is involved in signaling pathways that influence prostate cancer (PCa) progression. However, the role of human periprostatic adipose tissue (PPAT) from patients with benign prostatic hyperplasia (BPH) has not been studied and compared to PPAT PCa patients. The aim this paper was investigate factors derived both PPATs on behavior androgen-dependent castration resistant cells. Methods: conditioned media (CM) were obtained samples clinically primary...
Objective: To evaluate the relationship between testosterone levels and metabolic syndrome (MS) in men older than 45 years.
Abstract Purpose: Clinical and epidemiologic data suggest that obesity is associated with more aggressive forms of prostate cancer, poor prognosis, increased mortality. C-terminal–binding protein 1 (CtBP1) a transcription repressor tumor suppressor genes activated by NADH binding. High calorie intake decreases intracellular NAD+/NADH ratio. The aim this work was to assess the effect high-fat diet (HFD) CtBP1 expression modulation over xenograft growth. Experimental Design: We developed...
Objectives: To assess sex hormones, leptin and insulin-resistance in men with prostate cancer (PCa) benign prostatic hyperplasia (BPH) to study associations between androgens histologic score of tissue PCa.Subjects methods: Two hundred ten older than 45 years selected from 2906 participants a population screening for PCa were studied: 70 PCa, BPH controls (CG), matched by body mass index age. Insulin, IGF-1, PSA, leptin, total, free (fT) bioavailable testosterone (bT) estradiol measured....
Objective. To evaluate lipoprotein profile and sex hormones in patients with prostate cancer (PCa) benign prostatic hyperplasia (BPH) their possible associations some inflammatory markers linked to PCa.Methods. A total of 150 men (50–65 years), matched by age body mass index (BMI), included this study divided into three groups according specific antigen (PSA), digital rectal examination biopsy: 50 PCa, BPH controls. Total cholesterol (Chol), HDL-chol, LDL-chol, triglycerides (TG),...
Psychological factors and stressful life events (LE) are considered to play a role in the onset of metabolic syndrome (MS). We tested association between LE cortisol, marker chronic stress, with risk developing MS their interaction. From total number 2906 men who completed screening for early detection prostate cancer, 149 healthy (mean ± SD age, 58.6 7.7 years) were included this study. Participants assessed by Holmes Rahe questionnaire about experience during previous 1–5 years. was...
Some prostate cancers (PCas) are histo-pathologically grouped within the same Gleason Grade (GG), but can differ significantly in outcome. Herein, we aimed at identifying molecular biomarkers that could improve risk prediction PCa. LC ESI-MS/MS was performed on human PCa and benign prostatic hyperplasia (BPH) tissues peptide data integrated with omic analyses. We identified high YWHAZ NDRG1 expression to be associated poor prognosis considering all scores (GS). defined two subpopulations of...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Sep 2001GLANULOPLASTY WITH SCROTAL FLAP FOR PARTIAL PENECTOMY OSVALDO N. MAZZA and GERMÁN M.J. CHELIZ MAZZAOSVALDO CHELIZGERMÁN View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65857-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Reconstructing a penile stump secondary trauma or cancer should result in satisfactory...
Erectile dysfunction is associated with high blood pressure and antihypertensive treatment, especially diuretics traditional beta-blockers. Nevertheless, new beta-blockers such as nebivolol present some differences respect to the classic The aim of this study was determine functional morphologic effects on penile structures in hypertensive rats.During a 6-month period, male spontaneously rat (SHR) Wistar-Kyoto (WKY) rats were studied. groups follows: 1) untreated SHR (Untreated-SHR); 2)...
<i>Background:</i> Erectile dysfunction is highly prevalent in hypertensive patients. Since both angiotensin II receptor type-1 blockers (ARBs) and calcium antagonists are current effective antihypertensive drugs, the aim of this study was to determine possible differences between ARBs concerning protection penile structures from deleterious effects arterial hypertension. <i>Methods Results:</i> During 6 months, 3 groups male spontaneously rats (SHR) 1 Wistar-Kyoto...
Periprostatic adipose tissue (PPAT) directs tumour behaviour. Microenvironment secretome provides information related to its biology. This study was performed identify secreted proteins by PPAT, from both prostate cancer and benign hyperplasia (BPH) patients.Liquid chromatography-mass spectrometry-based proteomic analysis in PPAT-conditioned media (CM) patients with (CMs-T) (stage T3: CM-T3, stage T2: CM-T2) or disease (CM-BPH).The highest number diversity of identified CM-T3. Locomotion the...
Journal Article Protection of cavernous tissue in male spontaneously hypertensive rats: Beyond blood pressure control Get access Jorge Eduardo Toblli, Toblli 1Laboratory Experimental Medicine, Hospital Alemán, Buenos Aires, Argentina Address correspondence and reprint requests to Dr. E. Laboratory Department Internal Av. Pueyrredon 1640, Aires (1118), Argentina; e-mail: jtoblli@hospitalaleman.com Search for other works by this author on: Oxford Academic PubMed Google Scholar Inés Stella,...
The development of the spine is affected by both biological and mechanical factors. As geometry motion segment changes throughout growth, so does behaviour owing to changing vectors acting on a variable system.
The aim of this study was to determine fatty acid composition in periprostatic adipose tissue (PPAT) patients undergoing surgery for either prostatic cancer or benign hyperplasia (BPH). PPAT were obtained from 12 radical prostatectomy clinically localized prostate tumors (TPPAT, age range 55-70 years) and 11 adenomectomy BPH (BPPAT, 57-79 years). Fatty methyl esters total lipids processed then analyzed by gas chromatography-mass spectrometry. Quantitation performed comparing the percentage...