A5002493805- Research Data Management Practices
- Scientific Computing and Data Management
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Developmental Biology and Gene Regulation
- Artificial Intelligence in Healthcare and Education
- Environmental DNA in Biodiversity Studies
- Genomics and Chromatin Dynamics
- Meta-analysis and systematic reviews
- RNA and protein synthesis mechanisms
- Ethics in Clinical Research
- International Maritime Law Issues
- Ubiquitin and proteasome pathways
- TGF-β signaling in diseases
- Science and Climate Studies
- MicroRNA in disease regulation
- International Arbitration and Investment Law
- Congenital heart defects research
- Biomedical Ethics and Regulation
- Zebrafish Biomedical Research Applications
- Data Quality and Management
- Explainable Artificial Intelligence (XAI)
- Intellectual Property and Patents
- scientometrics and bibliometrics research
- Global Health Workforce Issues
Medical Technology and Practice Patterns Institute
2023-2025
Health Affairs
2023-2024
John Wiley & Sons (Germany)
2022-2023
Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures
2022
Springer Nature (United Kingdom)
2016-2020
Max Planck Institute for Molecular Genetics
2008-2011
Max Planck Society
2009-2011
Stanford University
2006
We call for journals to commit requiring open data be archived in a format that will simple and clear readers understand use. If applied consistently, these requirements allow contributors acknowledged their work through citation of data, facilitate scientific progress.
Open access to sequence data is a cornerstone of biology and biodiversity research, but has created tension under the United Nations Convention on Biological Diversity (CBD). Policy decisions could compromise research development, unless practical multilateral solution implemented. Ensuring international benefit-sharing from without jeopardising open sharing major obstacle for other UN negotiations. Here, authors propose address concerns both developing countries life scientists.
Researchers, supported by data from polyploid plants, have suggested that whole genome duplication (WGD) may induce genomic instability and rearrangement, an idea which could important implications for vertebrate evolution. Benefiting the newly released amphioxus sequence ( Branchiostoma floridae ), invertebrate researchers hoped is representative of ancestral chordate genome, we used gene proximity conservation to estimate rates rearrangement throughout vertebrates some their ancestors. We...
Animal genomes possess highly conserved cis -regulatory sequences that are often found near genes regulate transcription and development. Researchers have proposed the strong conservation of these may affect evolution surrounding genome, both by repressing rearrangement, possibly promoting duplicate gene retention. Conflicting data, however, made validity propositions unclear. Here, we use a new computational method to identify phylogenetically noncoding elements (PCNEs) in manner is not...
Sharing of experimental clinical research data usually happens between individuals or groups rather than via public repositories, in part due to the need protect participant privacy. This approach sharing makes it difficult connect journal articles with their underlying datasets and is often insufficient for ensuring access long term. Voluntary services such as Yale Open Data Access (YODA) Clinical Study Request (CSDR) projects have increased accessibility secondary uses while protecting...
Abstract Semaphorins are major regulators of morphogenesis and involved in a variety processes ranging from the guidance cell migration to development cancer. Since semaphorins were first characterized as repulsive neuronal cues, their expression has been best documented nervous system. However, broader studies lacking. Here, we describe 13 members semaphorin family two neuropilin receptors during early Xenopus laevis development. No particular pattern defines any classes, but many...
Given the inherent limitations of in silico studies relying solely on DNA sequence analysis, functional characterization mammalian promoters and associated cis-regulatory elements requires experimental support, which demands cloning analysis putative promoter regions. Focusing human chromosome 21, we cloned 182 gene 2500 bp length conducted reporter assays transfected-cell arrays. We found 56 that were active HEK293 cells, while another 49 could be activated by treatment cells with...
Abstract Background Studies of the Xenopus organizer have laid foundation for our understanding conserved signaling pathways that pattern vertebrate embryos during gastrulation. The two primary activities organizer, BMP and Wnt inhibition, can regulate a spectrum genes essentially all aspects embryo As knowledge grows, it is imperative we begin knitting together gene-level into genome-level models. goal this paper was to identify complete lists regulated by different signaling, thereby...
Abstract Sharing of experimental clinical research data usually happens between individuals or groups rather than via public repositories, in part due to the need protect participant privacy. This approach sharing makes it difficult connect journal articles with their underlying datasets and is often insufficient for ensuring access long term. Voluntary services such as Yale Open Data Access (YODA) Clinical Study Request (CSDR) projects have increased accessibility secondary uses while...
The scientific community has a strong tradition of sharing digital sequence information (DSI) in an unrestricted manner through public databases. While this “open access” many benefits, it created tension the context Convention on Biological Diversity (CBD). Differences opinion open access to DSI underlie key points divergence ongoing negotiations. CBD provided set policy options for DSI, but they are not granular enough assess whether compatible with principles. Here, we explain what means...