A5029915129- Cancer Cells and Metastasis
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Cancer, Hypoxia, and Metabolism
- Bone Tissue Engineering Materials
- Hydrogels: synthesis, properties, applications
- biodegradable polymer synthesis and properties
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Cancer Genomics and Diagnostics
- Cellular Mechanics and Interactions
- Polymer Surface Interaction Studies
- Mathematical Biology Tumor Growth
- Cardiac Valve Diseases and Treatments
- Cancer Research and Treatments
- Microtubule and mitosis dynamics
- Advanced Drug Delivery Systems
- Polysaccharides Composition and Applications
- Collagen: Extraction and Characterization
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- HIV Research and Treatment
- Marine Biology and Environmental Chemistry
- Aortic Disease and Treatment Approaches
University of Illinois Chicago
2024
University of Pittsburgh
2013-2022
McGowan Institute for Regenerative Medicine
2013-2022
UPMC Hillman Cancer Center
2017-2022
Swanson Center
2017-2022
Bioengineering (Switzerland)
2022
Case Western Reserve University
2020
Cornell University
2020
Glenmark Pharmaceuticals (India)
2018
Brigham and Women's Hospital
2010-2017
Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence any osteoinductive factor are reported. The presence triggers a set events follows temporal pattern differentiation. These findings underscore potential applications these designing bioactive scaffolds for musculoskeletal tissue engineering.
Porosity has been shown to be a key determinant of the success tissue engineered scaffolds. A high degree porosity and an appropriate pore size are necessary provide adequate space for cell spreading migration as well allow proper exchange nutrients waste between scaffold surrounding environment. Electrospun scaffolds offer attractive approach mimicking natural extracellular matrix (ECM) engineering applications. The efficacy electrospinning is likely depend on interaction cells geometric...
For tissue engineering applications, scaffolds should be porous to enable rapid nutrient and oxygen transfer while providing a three-dimensional (3D) microenvironment for the encapsulated cells. This dual characteristic can achieved by fabrication of hydrogels that contain In this work, we developed simple method allows cell encapsulation pore generation inside alginate simultaneously. Gelatin beads 150–300 µm diameter were used as sacrificial porogen generating pores within cell-laden...
During tissue morphogenesis and homeostasis, cells experience various signals in their environments, including gradients of physical chemical cues. Spatial temporal regulate cell behaviours such as proliferation, migration, differentiation during development, inflammation, wound healing, cancer. One the goals functional engineering is to create microenvironments that mimic cellular complexity found vivo by incorporating physical, chemical, temporal, spatial within engineered...
Poly(glycerol sebacate) (PGS) is a biodegradable elastomer that has generated great interest as scaffold material due to its desirable mechanical properties. However, the use of PGS in tissue engineering limited by difficulties casting micro- and nanofibrous structures, high temperatures vacuum required for curing solubility cured polymer. In this paper, we developed microfibrous scaffolds made from blends poly(ε-caprolactone) (PCL) using standard electrospinning set-up. At given PGS:PCL...
Heart valve-related disorders are among the major causes of death worldwide. Although prosthetic valves widely used to treat this pathology, current grafts cannot grow with patient while maintaining normal valve mechanical and hemodynamic properties. Tissue engineering may provide a possible solution issue through using biodegradable scaffolds patients’ own cells. Despite their similarity heart tissue, most hydrogel not mechanically suitable for dynamic stresses microenvironment. In study,...
Topographical cell guidance is utilized to engineer highly organized and aligned cellular constructs for numerous tissue engineering applications. Recently, electrospun scaffolds fabricated using poly(glycerol sebacate) (PGS) poly(-caprolactone) (PCL) have shown a great promise support valvular interstitial functions the development of engineered heart valves. However, one major drawbacks PGS-PCL lack control over alignment. In this work, we investigate role scaffold architecture on...
Abstract HIV-1 associated neurocognitive disorder (HAND) is characterized by neuroinflammation and glial activation that, together with the release of viral proteins, trigger a pathogenic cascade resulting in synaptodendritic damage neurodegeneration that lead to cognitive impairment. However, molecular events underlying HIV neuropathogenesis remain elusive, mainly due lack brain-representative experimental systems study HIV-CNS pathology. To fill this gap, we developed three-dimensional...
Fiber bundles are present in many tissues throughout the body. In most cases, collagen subunits spontaneously self-assemble into a fibrilar structure that provides ductility to bone and constitutes basis of muscle contraction. Translating these natural architectural features biomimetic scaffold still remains great challenge. Here, we propose simple strategy engineer fiber replicate self-assembly hierarchy fibers. The electrostatic interaction methacrylated gellan gum (MeGG) with...
Despite significant investments in cancer research and drug discovery/development, the rate of new approval is ≤5% most cases metastatic remain incurable. Ninety-five percent drugs fail clinical development because a lack therapeutic efficacy and/or unacceptable toxicity. One major factors responsible for low success anticancer failure preclinical models to adequately recapitulate complexity heterogeneity human cancer. For throughput capacity reasons, high-throughput screening growth...
Tumor size is strongly correlated with breast cancer metastasis and patient survival. Increased tumor contributes to hypoxic metabolic gradients in the solid an aggressive phenotype. Thus, it important develop three-dimensional (3D) models that recapitulate size-induced microenvironmental changes and, consequently, natural progression real time without use of artificial culture conditions or gene manipulations. Here, we developed size-controlled multicellular aggregates ("microtumors")...