A5057402830- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Polymer Synthesis and Characterization
- Electrical and Thermal Properties of Materials
- Surfactants and Colloidal Systems
- biodegradable polymer synthesis and properties
- Pickering emulsions and particle stabilization
- Electrospun Nanofibers in Biomedical Applications
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Drug Delivery Systems
- Polymer Nanocomposites and Properties
- Ferroelectric and Piezoelectric Materials
- Advancements in Transdermal Drug Delivery
- Biochemical and Molecular Research
- Thermal and Kinetic Analysis
- Conducting polymers and applications
- Nanomaterials and Printing Technologies
- Analytical Chemistry and Sensors
- Nanofabrication and Lithography Techniques
- Pigment Synthesis and Properties
- Electrowetting and Microfluidic Technologies
- Nanoparticle-Based Drug Delivery
- Acute Lymphoblastic Leukemia research
- Advanced Sensor and Energy Harvesting Materials
- Evasion and Academic Success Factors
- Bone Tissue Engineering Materials
Instituto de Pesquisas Tecnológicas
2012-2021
Industry and Parliament Trust
2017
Coordenação de Aperfeicoamento de Pessoal de Nível Superior
2014
Universidade de São Paulo
2009
The vibrating mesh spray technology implemented in the Nano Spray Dryer B-90 was evaluated for drug delivery applications by drying solutions containing different functional polymers to structure respective encapsulating matrices (Arabic gum, cashew nut sodium alginate, carboxymethyl cellulose and Eudragit RS100) a specific model be encapsulated (vitamin B12).A systematic study investigated influence of feeding liquid stream properties such as viscosity, conductivity surface tension...
L-asparaginase (ASNase) from Escherichia coli is currently used in some countries its PEGylated form (ONCASPAR, pegaspargase) to treat acute lymphoblastic leukemia (ALL). PEGylation refers the covalent attachment of poly(ethylene) glycol protein drug and it not only reduces immune system activation but also decreases degradation by plasmatic proteases. However, pegaspargase randomly and, consequently, with a high degree polydispersity final formulation. In this work we developed...
It is known that cetylpyridinium chloride (CPC) has in vitro and vivo antifungal action against Candida albicans, with advantages over other common antiseptics. A CPC delivery-controlled system, transported polymer nanofibers (PVP/PMMA), was developed to increase the bioavailability of drug contact oral mucosa. The objectives this study were determine if nanofiber C. what concentration it must be incorporated, so fraction released can yield an inhibitory concentration. prepared by...
The recognition of α-galactosylceramide (αGC), a high-affinity CD1d antigen, by the invariant Natural Killer T (iNKT) lymphocytes results in potent immunostimulatory responses that have been exploited advanced cancer patients. Therefore, to improve αGC biological activity, several studies vectorized this agonist PLGA and/or PEG-based nanoparticles. Despite promising findings, these approaches require steps, from organic solvent decontamination through extrusion membrane systems. Using nano...
The growing area of tissue engineering has the potential to alleviate shortage tissues and organs for transplantation, electrospun biomaterial scaffolds are extremely promising devices translating engineered into a clinical setting. However, be utilized in this capacity, these medical need sterile. Traditional methods sterilization not always suitable biomaterials, especially as many commonly used biomedical polymers sensitive chemical-, thermal- or radiation-induced damage. Therefore,...
Composites of magnetite nanoparticles encapsulated with polymers attract interest for many applications, especially as theragnostic agents magnetic hyperthermia, drug delivery, and resonance imaging. In this work, were synthesized by coprecipitation different (Eudragit S100, Pluronic F68, Maltodextrin, surfactants) nano spray drying technique, which can produce powders from solutions or suspensions. Transmission scanning electron microscopy images showed that the bare have 10.5 nm, after...
A new kind of thermo-responsive particles were prepared by the self-assembly technique, comprising poly(hydroxyvalerate-co-hydroxybutirate)-b-poly(N-isopropylacrylamide)/ (PHBHV-b-PNIPAAm) block copolymers. The hydrophilic part PNIPAAm was synthesized Reversible Addition- Fragmentation chain Transfer (RAFT) polymerization. Particles with core-shell morphology obtained outer shells and hydrophobic inner cores. Dexametasone acetate (DexAc) used as a model drug an encapsulation efficiency 77%....
Nanoparticles have been used to improve the properties of many cosmetic products, mainly sunscreens materials using nanoencapsulation or nanosuspensions, improving contact with active molecules, enhancing sun protection effect and facilitating formulations in industrial products. Microfluidic devices offer an important possibility producing nanoparticles a simple way, one step bottom up technique, continuum process low polidispersivity, consumption reagents additives. In this work, we...
Microfluidic devices have become an important tool to produce micro and nanoparticles. However, the operation ranges of these systems are still a challenge when we think large scale industrial applications. In this work present two microfluidic for scaling up nanoprecipitation process. The microfabricated in glass substrates flow distribution done through reservoirs branching system, with four outputs each device. can operate mL/min range it is possible yield ten times higher than single...
Nanoprecipitation is a nanonization technique used for nanoparticle generation. Several fields, like pharmacology and fine chemistry, make use of such technique. Typically are bulky batch mechanical processes rendering high polydispersity index generated nanoparticles, poorly particle size reproducibility energy wasting. LTCC-based microsystem technologies allow the implementation different unitary operations chemical process, making it an enabling technology miniaturization processes. In...
The aim of this research was to characterize emulsion systems (ES) containing nonionic ethoxylated surfactants by using rheological, microscopic, and thermogravimetric assays. Three formulations were developed: ES-1: 8.0% (w/w) oleth-20; ES-2: 4.0% oleth-20 / steareth-21; ES-3: steareth-21. showed typical non-Newtonian pseudo-plastic behavior. presence a lamellar gel phase observed for all systems, with ES-2 being more pronounced. Through thermogravimetry, the profiles three found be...
Poly(ε-caprolactone)-block-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, triblock) and Poly(ε-caprolactone)-block-(poly(ethylene oxide)−poly(propylene oxide)−poly(ethylene oxide)-poly (ε-caprolactone) (PCL-PEO-PPO-PEO-PCL, pentablock) copolymers were synthesized by transesterification with reduction of PCL molecular mass, enabling fewer reactions, lower temperatures, eliminating extensive purification steps. Free hydrophilic groups removed from the samples selective precipitation,...
Abstract The present work shows a ceramics microfluidic device for non-miscible fluids microemulsion generation using 3D serpentine micromixers. technology used fabrication was Low Temperature Cofired Ceramics (LTCC) which allows us complex, high temperature and pressure resistant devices. proposed aims to obtain with controlled drop size, low dispersion index production volumes Top-Down approach. Previous simulation had showed as one of the best structures rapid mixing due chaotic advection...