A5068536562- Traumatic Brain Injury and Neurovascular Disturbances
- Mesenchymal stem cell research
- Cancer Genomics and Diagnostics
- Hip and Femur Fractures
- Cellular Mechanics and Interactions
- Nanoparticle-Based Drug Delivery
- Bladder and Urothelial Cancer Treatments
- Nanoplatforms for cancer theranostics
- Hydrogels: synthesis, properties, applications
- RNA Interference and Gene Delivery
- Elasticity and Material Modeling
- Electrospun Nanofibers in Biomedical Applications
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Silk-based biomaterials and applications
- Electrohydrodynamics and Fluid Dynamics
- Renal and related cancers
- Anesthesia and Neurotoxicity Research
- MicroRNA in disease regulation
- Block Copolymer Self-Assembly
- Tissue Engineering and Regenerative Medicine
- Metastasis and carcinoma case studies
- 3D Printing in Biomedical Research
- Orthopaedic implants and arthroplasty
Natera (United States)
2023-2024
Rose–Hulman Institute of Technology
2021
The Ohio State University
2013-2020
Duke University
2020
Bone defects can originate from a variety of causes, including trauma, cancer, congenital deformity, and surgical reconstruction. Success the current "gold standard" treatment (i.e., autologous bone grafts) is greatly influenced by insufficient or inappropriate stock. There thus critical need for development new, engineered materials repair. This review describes use natural synthetic hydrogels as scaffolds tissue engineering. We discuss many advantages that offer repair materials, their...
Appropriately modulating inflammation after traumatic brain injury (TBI) may prevent disabilities for the millions of those inflicted annually. In TBI, cellular mediators inflammation, including macrophages and microglia, possess a range phenotypes relevant an immunomodulatory therapeutic approach. It is thought that early phenotypic modulation these cells will have cascading healing effect. fact, anti-inflammatory, "M2-like" macrophage phenotype TBI has been associated with neurogenesis,...
Circulating tumor DNA (ctDNA) detection in blood has emerged as a prognostic and predictive biomarker demonstrating improved assessment of treatment response patients receiving immune checkpoint inhibitors (ICIs). Here, we performed pilot study to support the role ctDNA for longitudinal monitoring with advanced genitourinary (GU) malignancies ICIs.Patients histologically confirmed GU were prospectively enrolled. All eligible received ICI at least 12 weeks, followed by serial collection...
Despite curative-intent radical cystectomy (RC), patients with muscle-invasive bladder cancer (MIBC) are at high risk of recurrence. Biomarkers urgently needed to refine prognostication and selection appropriate perioperative systemic therapies. Our aim was evaluate the prognostic predictive value tumor-informed circulating tumor DNA (ctDNA) results in a multicenter cohort who underwent RC.
With their high degree of specificity and investigator control, in vitro disease models provide a natural complement to vivo models. Especially organs such as the brain, where anatomical limitations make experiments challenging, have been increasingly used mimic pathology. However, brain mimetic may not fully replicate mechanical environment vivo, which has shown influence variety cell behaviors. Specifically, many consider only linear elastic modulus describes stiffness material with...
PURPOSE Tumor-informed circulating tumor DNA (ctDNA) has shown promise as a biomarker for treatment response monitoring (TRM) in variety of types, with the potential to improve clinical outcomes. We evaluated ctDNA status and dynamics during surveillance part TRM outcomes both patients clear cell renal carcinoma (ccRCC) non–clear (nccRCC) treated standard-of-care immunotherapy or targeted therapy regimens. METHODS This was multicenter retrospective analysis real-world data obtained from...
Purpose: Poly(lactic- co -glycolic acid) (PLGA) is widely used for drug delivery because of its biocompatibility, ability to solubilize a wide variety drugs, and tunable degradation. However, achieving sub-100 nm nanoparticles (NPs), as might be desired via the enhanced permeability retention effect, extremely difficult typical top-down emulsion approaches. Methods: Here, we present bottom-up synthesis method yielding PLGA/block copolymer hybrids (ie, "PolyDots"), consisting hydrophobic PLGA...
Abstract Glioblastoma (GBM) is an astrocytic brain tumor with median survival times of <15 months, primarily as a result high infiltrative potential and development resistance to therapy (i.e., surgical resection, chemoradiotherapy). A prominent feature the GBM microenvironment compressive solid stress (CSS) caused by uninhibited growth within confined skull. Here, we utilized mechanical compression model apply CSS (<115 Pa) well-characterized LN229 U251 cell lines measured their...
Poly(ethylene glycol) (PEG)-based hydrogel-electrospun fiber mat (EFM) composites are a promising new controlled release system for hydrophilic drugs, providing longer and more linear characteristics accompanied by smaller initial burst than traditional hydrogel systems. However, the effect of EFM properties on has not yet been examined. Here, we investigated influence thickness hydrophobicity swelling behavior using bovine serum albumin as model protein. EFMs were comprised...
Electrospun fiber mats (EFMs) are highly versatile biomaterials used in a myriad of biomedical applications. Whereas some facets EFMs well studied and can be tuned (e.g., pore size, diameter, etc.), other features under characterized. For example, although substrate mechanics have been explored by several groups, most studies rely on Young’s modulus alone as characterization variable. The influence mat thickness the effect supports variables that often not considered when evaluating...
Abstract Appropriately modulating inflammation after traumatic brain injury (TBI) may prevent disabilities for the millions of those inflicted annually. In TBI, cellular mediators inflammation, including macrophages and microglia, possess a range phenotypes relevant an immunomodulatory therapeutic approach. It is thought that early phenotypic modulation these cells will have cascading healing effect. fact, anti-inflammatory, “M2-like” macrophage phenotype TBI has been associated with...
Abstract Background: Conventional chemotherapy strategies against malignant primary brain tumors such as glioblastoma have limited success in improving clinical outcome. There is a need for novel anti-glioma treatment that efficiently transgress the blood barrier (BBB), specifically target tumor, provide sustained drug release, allow combination to overcome resistance, and imaging correlates delivery. We hypothesized nanoparticle delivery systems, which can bypass BBB access tumor cells,...
Standard therapies have limited success against malignant primary brain tumors such as glioblastoma (GB) raising the need for novel that can efficiently transgress blood barrier (BBB), target tumor and provide sustained drug release. Nanoparticle delivery systems which bypass BBB nervous system cells allowing combined of therapeutic agents with unique advantages compared to conventional agents. We developed a nanodelivery vehicle called PolyDots combines features nanomicelles polymer...
You have accessJournal of UrologyCME1 Apr 2023PD36-05 ASSESSMENT OF CIRCULATING TUMOR DNA STATUS AS A PROGNOSTIC MARKER FOR RECURRENCE DETECTION IN PATIENTS WITH MUSCLE INVASIVE BLADDER CANCER Shivaram Cumarasamy, George Laliotis, Elshaddai White, Jordan Rich, Punashi Dutta, Shruti Sharma, Mark Calhoun, Adam Elnaggar, Minetta Liu, Kyrollis Attalla, Reza Mehrazin, Peter Wiklund, and John Sfakianos CumarasamyShivaram Cumarasamy More articles by this author , LaliotisGeorge Laliotis...
Abstract Background: Standard treatment of localized muscle invasive bladder cancer (MIBC) is neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC); however, only 40-50% respond to NAC and approx. 50% experience relapse. Evaluation efficacy early detection relapse are therefore major clinical challenges. Methods: We present a update previously described cohort 68 patients who received prior RC (NAC cohort; Christensen et al. JCO 2019; median follow-up (FU) 58 months) together...
Arthritis affects 26.3% of adults and approximately 50,000 children in the United States [1]. Hydrogel drug-delivery systems have been considered as a viable option for drug delivery to arthritic articular cartilage knee. To determine physiologically relevant loading, Qualisys motion capture system was used analyze gait college-aged females they took several steps on flat surface, then stepped onto force plate. The plate data maximum exerted knee during normal gait. Three different...