A5054441753- Fatigue and fracture mechanics
- Bone Tissue Engineering Materials
- High Temperature Alloys and Creep
- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Fire effects on concrete materials
- Microstructure and Mechanical Properties of Steels
- Craniofacial Disorders and Treatments
- Anatomy and Medical Technology
- Orthopaedic implants and arthroplasty
- Facial Trauma and Fracture Management
- Probabilistic and Robust Engineering Design
- Magnesium Alloys: Properties and Applications
- Morphological variations and asymmetry
- Dental Implant Techniques and Outcomes
- Aluminum Alloys Composites Properties
- Nanoplatforms for cancer theranostics
- Titanium Alloys Microstructure and Properties
- Groundwater flow and contamination studies
- Photodynamic Therapy Research Studies
- Material Properties and Failure Mechanisms
- Non-Destructive Testing Techniques
- biodegradable polymer synthesis and properties
- Shape Memory Alloy Transformations
- Nuclear Materials and Properties
Lincoln University
2025
The Ohio State University
2015-2024
EDF Energy (United Kingdom)
2012-2021
Électricité de France (France)
2016
Beth Israel Deaconess Medical Center
2016
Case Western Reserve University
2005-2014
Neurological Surgery
2002-2013
Institute of Technology Assessment
2010-2011
Plant Integrity (United Kingdom)
2001-2011
Rice University
1999-2009
Abstract A novel approach to the manufacture of biodegradable polymeric scaffolds for tissue‐engineering utilizing stereolithography (SLA) is presented. SLA a three‐dimensional (3D) printing method that uses an ultraviolet laser photo‐crosslink liquid polymer substrate. The current generation devices provide 3D resolution 0.1 mm. experiments utilized resin mixture diethyl fumarate (DEF), poly(propylene fumarate) (PPF), and photoinitiator, bisacylphosphine oxide (BAPO). PPF crosslinked with...
There is an unmet need for a consistent set of tools the evaluation 3D-printed constructs. A toolbox developed to design, characterize, and evaluate poly(propylene fumarate) scaffolds proposed vascularized engineered tissues. This combines modular design non-destructive fabricated evaluation, evaluates biocompatibility mechanical properties, models angiogenesis.
Abstract The treatment of large cranial defects may be greatly improved by the development precisely formed bone tissue engineering scaffolds. Such scaffolds could constructed using UV laser stereolithography to photocrosslink a linear, biodegradable polymer into three‐dimensional implant. We have previously presented method polyester, poly(propylene fumarate) (PPF). To ensure safety and effectiveness this technique, soft hard response photocrosslinked PPF different pore morphologies was...
This study evaluated the in vitro cytotoxicity of poly(propylene fumarate) (PPF). PPF is an aliphatic biodegradable polymer that has been well characterized for use bone tissue engineering scaffolds. Four different cell types, human mesenchymal stem cells (hMSC), fibroblasts (L929), preosteoblasts (MC3T3), and canine (cMSC), were used to evaluate PPF. These types represent tissues would interact with vivo as a scaffold. The sol fraction films was measured then utilized estimate cross-linking...
The intercellular signaling mechanisms among a transplanted cell population are largely determined by the itself as well surrounding environment. Changes in cell-to-cell paracrine distance can be obtained altering density, and signal expression of growth factors enhanced auto/paracrine transduction. To examine these relationships, we investigated effect seeding density on viability, proliferation, differentiation, endogenous osteogenic rat bone marrow stromal cells (BMSCs) cultured 2D disk....
Complex three-dimensional (3D) pore geometries, useful for tissue engineering scaffolds, can be fabricated via photo-crosslinking of resorbable poly(propylene fumarate) (PPF) resins using stereolithography (SLA) and/or continuous digital light processing (cDLP) methods. Physico-chemical parameters inherent to 3D printable resin design, include viscosity, polymer concentration, degree polymerization, and printing temperature. We report here on our study these their influence the cDLP process...
Highly accurate rendering of the external and internal geometry bone tissue engineering scaffolds effects fit at defect site, loading pore spaces with cells, bioreactor-delivered nutrient growth factor circulation, scaffold resorption. It may be necessary to render resorbable polymer 50 μm or less accuracy achieve these goals. This level is available using Continuous Digital Light processing (cDLP) which utilizes a DLP(®) (Texas Instruments, Dallas, TX) chip. One such additive manufacturing...
Additive manufacturing of nickel–titanium has two distinct advantages over conventional methods. It circumvents the difficulties associated with machining and it provides a freedom-of-design that processing cannot match. In this article, we analyze effects parameters on structural functional outcomes selective laser melted parts. Notably, expand parametric envelope compared to previous studies by utilizing higher power 300 W laser. Optimal process are identified for additively parts verified...
This paper describes the morphology and phylogenetic significance of a well-preserved fossil human cranium found near Reilingen, Germany in 1978. The specimen consists two complete parietals, most right temporal, 70% occipital. displays several features characteristic early “archaic”Homo sapiens: maximum breadth at supramastoid crests, roughly pentagonal occipital view, an angular torus, superoinferiorly elongate/anteroposterior shortened squamous strong mastoid, separation tympanic mastoid...
The photocross-linking of poly(propylene fumarate) (PPF) to form porous scaffolds for bone tissue engineering applications was investigated. PPF cross-linked using the photoinitiator bis(2,4,6-trimethylbenzoyl) phenylphosphine oxide (BAPO) and exposure 30 min long wavelength ultraviolet (UV) light. photocross-linked (6.5 mm diameter cylinders) were synthesized by including a NaCl porogen (70, 80, 90 wt% at cross-linking) prior photocross-linking. After UV exposure, samples placed in water...
▪ Abstract Photoinitiated polymerization and polymer crosslinking are viable strategies for biomaterial synthesis because of the mild temperatures neutral pH environments in which these reactions typically take place. This review summarizes relevant theories as well current status photoinitiated polymerizations biomaterials. Photoinitiation, polymerization, photoinitiators discussed with consideration toward biological nature intended application. Recent investigations into biomaterials,...
Bone defects can originate from a variety of causes, including trauma, cancer, congenital deformity, and surgical reconstruction. Success the current "gold standard" treatment (i.e., autologous bone grafts) is greatly influenced by insufficient or inappropriate stock. There thus critical need for development new, engineered materials repair. This review describes use natural synthetic hydrogels as scaffolds tissue engineering. We discuss many advantages that offer repair materials, their...