A5016535847- Hippo pathway signaling and YAP/TAZ
- Occupational and environmental lung diseases
- Respiratory and Cough-Related Research
- Renal and related cancers
- Voice and Speech Disorders
- Genetic factors in colorectal cancer
- Cancer Research and Treatments
- Pluripotent Stem Cells Research
- Management and Organizational Practices
- Wnt/β-catenin signaling in development and cancer
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Transplantation: Methods and Outcomes
- Dysphagia Assessment and Management
- Pancreatic function and diabetes
- Microtubule and mitosis dynamics
- Brain Metastases and Treatment
- Lipid metabolism and biosynthesis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hemodynamic Monitoring and Therapy
- Glioma Diagnosis and Treatment
- Asthma and respiratory diseases
- Lung Cancer Research Studies
- Non-Invasive Vital Sign Monitoring
- Mental Health and Psychiatry
The Maria Sklodowska-Curie National Research Institute of Oncology
2024
Medical University of Warsaw
2022-2024
VIB-KU Leuven Center for Cancer Biology
2019-2023
Vlaams Instituut voor Biotechnologie
2018-2020
KU Leuven
2018-2020
The Hippo signaling pathway and its two downstream effectors, the YAP TAZ transcriptional coactivators, are drivers of tumor growth in experimental models. Studying mouse models, we show that can also exert a tumor-suppressive function. We found normal hepatocytes surrounding liver tumors displayed activation deletion Yap Taz these peritumoral accelerated growth. Conversely, hyperactivation triggered regression primary melanoma-derived metastases. Furthermore, whereas cells growing wild-type...
The Hippo signaling pathway is widely considered a master regulator of organ growth because the prominent overgrowth phenotypes caused by experimental manipulation its activity. Contrary to this model, we show here that removing transcriptional output did not impair ability mouse liver and Drosophila eyes grow their normal size. Moreover, activity effectors Yap/Taz/Yki correlate with cell proliferation, hyperactivation these induced gene expression programs recapitulate development....
Background and AimsThe Hippo pathway its downstream effectors YAP TAZ (YAP/TAZ) are heralded as important regulators of organ growth regeneration. However, different studies provided contradictory conclusions about their role during regeneration organs, ranging from promoting proliferation to inhibiting it. Here we resolve the function YAP/TAZ liver, where Hippo's in control has been studied most intensely.MethodsWe evaluated liver after carbon tetrachloride toxic injury mice with...
Abstract The Hippo pathway and its downstream effectors, the YAP TAZ transcriptional coactivators, are deregulated in multiple different types of human cancer required for cell phenotypes vitro vivo, while largely dispensable tissue homeostasis adult mice. YAP/TAZ their main partner transcription factors, TEAD1–4 therefore promising anticancer targets. Because frequent hyperactivation caused by mutations components NF2 LATS2, mesothelioma is one prime predicted to be responsive YAP/TAZ-TEAD...
Significance The Hippo pathway is an important regulator of animal growth, and its effector, Yorkie (in flies) or YAP/TAZ mammals), drives the expression genes needed for cell proliferation survival. In effort to identify new regulators Yorkie, we performed a genetic modifier screen in Drosophila . this screen, identified RNA-binding protein Hrb27C as positive activity that modulates phosphorylation status. Additional experiments interacting proteins Glorund, Halfpint, Squid, Pabp2 negative...
Abstract Objective. Most current algorithms for detecting atrial fibrillation (AF) rely on heart rate variability (HRV), and only a few studies analyse the of photopletysmography (PPG) waveform. This study aimed to compare morphological features PPG curve in patients with AF those presenting normal sinus rhythm (NSR) evaluate their usefulness detection. Approach. 10 min signals were obtained from persistent/paroxysmal NSR. Nine parameters (1/Δ T ), Pulse Width [PW], augmentation index [AI],...
<p>Figure S2 shows A) Heatmap showing YAP signature genes in vehicle and SWTX-143-treated kidney cancer cell line. B) Gene Set Enrichment Analysis of the signature.</p>
<p>Figure S4 shows A) Immunofluorescence stainings of lung sections from mice with mesothelioma after 2 weeks Adeno-Cre injection, stained for Vimentin (green) and Mesothelin (red). B) Picture an H&E staining a section mouse that was treated SWTX-143 one week.</p>
<p>Figure S1 shows A) Fraction of transfected cells after re-expression NF2 in HEK293 and NF2-mutant mesothelioma cell lines. The proliferation lines, but not the wild-type cells, is suppressed by overexpression. B) Effect SWTX-143 on Hippo-wild type line H2062.</p>
<p>Figure S3 shows Heatmap of differential pathway analysis comparing the tumors vehicle and SWTX-143-treated mice.</p>
<p>Figure S3 shows Heatmap of differential pathway analysis comparing the tumors vehicle and SWTX-143-treated mice.</p>
<div>Abstract<p>The Hippo pathway and its downstream effectors, the YAP TAZ transcriptional coactivators, are deregulated in multiple different types of human cancer required for cell phenotypes <i>in vitro</i> vivo</i>, while largely dispensable tissue homeostasis adult mice. YAP/TAZ their main partner transcription factors, TEAD1–4 therefore promising anticancer targets. Because frequent hyperactivation caused by mutations components <i>NF2</i>...
<p>Figure S4 shows A) Immunofluorescence stainings of lung sections from mice with mesothelioma after 2 weeks Adeno-Cre injection, stained for Vimentin (green) and Mesothelin (red). B) Picture an H&E staining a section mouse that was treated SWTX-143 one week.</p>
<p>X-ray specifications</p>
<p>Figure S2 shows A) Heatmap showing YAP signature genes in vehicle and SWTX-143-treated kidney cancer cell line. B) Gene Set Enrichment Analysis of the signature.</p>
<div>Abstract<p>The Hippo pathway and its downstream effectors, the YAP TAZ transcriptional coactivators, are deregulated in multiple different types of human cancer required for cell phenotypes <i>in vitro</i> vivo</i>, while largely dispensable tissue homeostasis adult mice. YAP/TAZ their main partner transcription factors, TEAD1–4 therefore promising anticancer targets. Because frequent hyperactivation caused by mutations components <i>NF2</i>...
<p>Figure S1 shows A) Fraction of transfected cells after re-expression NF2 in HEK293 and NF2-mutant mesothelioma cell lines. The proliferation lines, but not the wild-type cells, is suppressed by overexpression. B) Effect SWTX-143 on Hippo-wild type line H2062.</p>
<p>X-ray specifications</p>
<title>Abstract</title> Background Asthma underdiagnosis and overdiagnosis remain significant problems for healthcare systems worldwide indicate considerable pain points with current guidelines diagnostic methods; therefore, new, targeted approaches seem crucial. This study introduces a novel spirometry-based approach using digital tools objective asthma diagnosis. Methods was single-centre (Warsaw Medical University, Poland), prospective cohort study. It included adults suspected per GINA...
Asthma underdiagnosis and overdiagnosis remain significant problems for healthcare systems worldwide indicate considerable pain points with current guidelines diagnostic methods; therefore, new, targeted approaches seem crucial. This study introduces a novel spirometry-based approach using digital tools objective asthma diagnosis support. was single-centre (Warsaw Medical University, Poland) prospective cohort study. It included adults suspected per GINA 2020, without confirmed obstruction...
Cardiovascular diseases (CVDs) are major concerns in the healthcare system. An individual diagnostic approach and personalized therapy key areas of an effective therapeutic process. The aims this study were: (1) to assess leading patient problems related symptoms, diagnosis, treatment CVDs, (2) examine patients' opinions about system Poland, (3) provide a proposal practical solutions. 27-point author's questionnaire was distributed Cardiology Department Tertiary Care Centre between 2nd...