A5038109182- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Brain Metastases and Treatment
- Urinary and Genital Oncology Studies
- Lung Cancer Research Studies
- Testicular diseases and treatments
- Cancer, Lipids, and Metabolism
- Multiple Myeloma Research and Treatments
- Transplantation: Methods and Outcomes
- PARP inhibition in cancer therapy
- Sarcoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Hematopoietic Stem Cell Transplantation
- Gastric Cancer Management and Outcomes
- Protein Degradation and Inhibitors
- Bone health and treatments
- COVID-19 Clinical Research Studies
- Adrenal Hormones and Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Polyomavirus and related diseases
Ente Ospedaliero Cantonale
2021-2025
Institute of Oncology Research
2021-2025
Università della Svizzera italiana
2023-2024
AGO Austria
2019
St. Joseph Hospital
2014-2015
Medical University of Vienna
2010-2013
Abstract Inflammation is a hallmark of cancer 1 . In patients with cancer, peripheral blood myeloid expansion, indicated by high neutrophil-to-lymphocyte ratio, associates shorter survival and treatment resistance across malignancies therapeutic modalities 2–5 Whether inflammation drives progression prostate in humans remain unclear. Here we show that inhibition chemotaxis can reduce tumour-elicited reverse therapy subset metastatic castration-resistant (CRPC). We higher ratio reflects...
The VHL protein (pVHL) is a multiadaptor that interacts with more than 30 different binding partners involved in many oncogenic processes. About 70 % of clear cell renal carcinoma (ccRCC) have mutations varying impact on pVHL function. Loss function leads to the accumulation Hypoxia Inducible Factor (HIF), which targeted by current treatments. In contrast nonsense and frameshift highly likely nullify multipurpose functions, missense may rather specifically influence capability its partners....
TPS280 Background: The implementation of androgen-receptor pathway inhibitors (ARPI) +/- docetaxel (doce) in addition to androgen deprivation therapy (ADT)in metastatic hormone sensitive prostate cancer (mHSPC) has limited the therapeutic options mCRPC setting. In SAKK 08/16 trial, darolutamide (daro) maintenance demonstrated prolonged radiographic progression-free survival (rPFS) compared placebo patients (pts) with who had received prior ARPI, and did not progress during taxane therapy....
Bronchiolitis obliterans (BO) is a detrimental late pulmonary complication after allogeneic hematopoietic stem cell transplantation (HCT) associated with chronic graft-versus-host disease (cGvHD). When systemic immunosuppressive treatment fails to improve, severe BO patients should be considered for lung (LuTX). We present seven undergoing LuTX refractory HCT.Seven hematologic malignancies developed cGvHD involvement presenting as HCT. Evaluation was initiated failure of median 4...
e17111 Background: Androgen deprivation therapy (ADT) increases the risk of fractures. The addition an androgen receptor pathway inhibitor (ARPI) to ADT (MAB) has shown improve outcomes compared monotherapy in patients (pts) with metastatic castration-resistant PC (mCRPC), non-mCRPC (nmCRPC), hormone-sensitive (mHSPC), high-risk localized disease and biochemical relapse. There is no definitive evidence whether MAB fractures alone. Methods: We conducted a systematic review all clinical trials...
Background: CD97 is a member of the epidermal growth factor-seven transmembrane (EGF-TM7) receptor family and dominantly expressed on immune cells in variety malignant diseases. B7-H1 B7-H3 are proteins that involved suppression system. The aim this study was to evaluate if these molecules up-regulated patients with cancer change during chemotherapy. Materials Methods: We analyzed cluster differentiation (CD) protein expression levels tumor cell lines blood samples 37 solid tumors at...