A5078212994- Peripheral Artery Disease Management
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Cardiac and Coronary Surgery Techniques
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Diagnosis and Treatment of Venous Diseases
- Vascular Procedures and Complications
- Mechanical Circulatory Support Devices
- Cardiac Ischemia and Reperfusion
- Vascular anomalies and interventions
- Venous Thromboembolism Diagnosis and Management
- Infectious Aortic and Vascular Conditions
- Cardiac Structural Anomalies and Repair
- Cerebrovascular and Carotid Artery Diseases
- Pulmonary Hypertension Research and Treatments
- Cardiac electrophysiology and arrhythmias
- Abdominal vascular conditions and treatments
- Diabetic Foot Ulcer Assessment and Management
- Lipoproteins and Cardiovascular Health
- Ion channel regulation and function
- Infective Endocarditis Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Nitric Oxide and Endothelin Effects
- Muscle and Compartmental Disorders
Kansai Medical University
2015-2024
Ministry of Health Labour and Welfare
2024
University Medical Center
2018-2023
Tokyo Medical University
2009-2018
Tokyo Medical University Hachioji Medical Center
2012-2018
National Cerebral and Cardiovascular Center
1991-2014
Wakayama Rosai Hospital
2006-2009
Saiseikai Wakakusa Hospital
2005-2008
Wakayama Medical University
1996-2005
Institute of Child Health
1993-1996
Milk xanthine oxidase has been isolated in good yield and purity from pasteurized buttermilk found to contain FAD, molybdenum, iron, labile sulfide the ratio of 1:1:4:4. Analytical data on spectral characteristics enzyme oxidized various reduced states are presented. The anaerobic reduction by substrates proceeds two phases: a catalytically significant fast phase very much slower secondary phase. Anaerobic titration studies indicate that per eq enzyme-bound FAD 4-electron occurs phase: 3...
Abstract The FAD prosthetic group of milk xanthine oxidase has been removed by treatment with high concentrations CaCl2. This agent shown to promote the hydrolysis FMN. deflavoenzyme be devoid oxygen reductase activity, and can reconstituted a short incubation FAD. Reconstitution activity was also obtained FMN; however, were required. absorption circular dichroism spectra are similar those simple iron-sulfur proteins such as ferredoxins. Rapid reaction studies have that is rapidly reduced...
Characteristics of peripheral arterial disease (PAD) are the occlusion or stenosis multiple vessel sites caused mainly by atherosclerosis and chronic lower limb ischemia. To identify PAD susceptible loci, we conducted a genome-wide association study (GWAS) with 785 cases 3,383 controls in Japanese population using 431,666 single nucleotide polymorphisms (SNP). After staged analyses including total 3,164 20,134 controls, identified 3 novel susceptibility loci at IPO5/RAP2A, EDNRA HDAC9 genome...
The amount of readily exchangeable Ca2+ in mitochondria an isolated working rat heart is less than 10 ng-ions/g heart. We therefore conclude that either no enters or the Ca+ which does enter removed continuously. Using Sr2+ and Mn2+, we obtained evidence mitochondrial Na+-Ca2+ exchanger was indeed operational releasing metal from When perfusate replaced by Sr2+, found a significant (approximately 100 heart) entered mitochondria. then returned to Ca2+-containing perfusate, over 80% washed out...
Quantifying the risks and benefits of revascularization for chronic limb-threatening ischaemia (CLTI) is important. The aim this study was to create a risk prediction model treatment outcomes 30 days after in patients with CLTI.Consecutive CLTI who had undergone between 2013 2016 were collected from JAPAN Critical Limb Ischemia Database (JCLIMB). cohort divided into development validation cohort. In cohort, multivariable models constructed predict major amputation and/or death adverse limb...
The most important vascular lesion associated with diabetes is arteriosclerosis obliterans (ASO). Differential diagnosis from diabetic foot lesions that produce neurogenic ulcers important, and the presence of ischemia must be diagnosed as soon possible. It has been reported makes ASO more severe often leads to lower extremity amputation. In addition need for appropriate early control diabetes, surgeons are required perform immediate revascularization in cases ulcer necrosis, aggressively...
To assess the utility of skin perfusion pressure (SPP) measurement in evaluating outcome vascular constructions for critical limb ischemia (CLI) patients.We retrospectively studied 19 lower limbs 18 patients who underwent arterial reconstruction CLI from whom SPP measurements had been obtained pre- and postoperatively between 2008 2010. Six whose ulcers healed were classified into group H, 7 not U, 6 without N. values compared among these groups.The preoperative all groups <30 mmHg,...
A flow-mediated endothelium-dependent vasodilation and endothelium-independent nitroglycerin-induced were carried out in 70 patients 15 age-matched adults without any atherosclerotic risk factors to clarify vascular responsiveness with peripheral disease. The percent change was significantly lower than controls (5.4 +/- 0.7% vs 12.8 2.2%, P < .001). Moreover, the measured after sublingual administration of nitroglycerin (5.8 0.6% 10.2 1.5%, .01). On multiple regression analysis, none...
Background: The results of paramalleolar distal bypass for critical limb ischemia in patients with peripheral arterial disease were reviewed to determine the factors affecting long-term patency this procedure Japanese subjects. Methods and Results: A total 65 legs from 60 consecutive who underwent ankle retrospectively reviewed. Postoperative graft patency, morbidity mortality analyzed. All monitored during a mean follow-up period 2.2±1.7 years (median, 1.7 years). accumulated primary...
Abstract We performed ten operations in children using a lower mid-line incision and limited minimal sternotomy. The skin is made from the level of nipples to end xiphoid process, only body sternum cut vertically. There was neither operative mortality nor complications. upper limit scar was, at most, 1 cm beyond nipples, difficult observe typical open-necked shirts. believe our method suitable fulfilling cosmetic needs for eligible children.
Department of Anesthesiology, Center for Health Sciences, University Wisconsin, Madison, Wisconsin
Pulmonary arterial (PA) endothelial cell morphology changes during cold preservation. In the present study, efficacy of University Wisconsin solution (UW), UW without colloid (modified UW), Euro-Collins (EC), Marshall's (MS), and medium 199 + 10% fetal calf serum [culture (CM)] in maintaining regaining cytoskeleton cultured porcine PA cells kept at 4 degrees C then rewarmed was compared. Features studied were actin, microtubules, vinculin, talin, using immunofluorescence, sodium dodecyl...