- Tendon Structure and Treatment
- Bee Products Chemical Analysis
- Combustion and flame dynamics
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Fluid Dynamics and Turbulent Flows
- Aerodynamics and Acoustics in Jet Flows
- Laser Applications in Dentistry and Medicine
- Nerve Injury and Rehabilitation
- Workplace Health and Well-being
- Particle Dynamics in Fluid Flows
- IoT and Edge/Fog Computing
- Balance, Gait, and Falls Prevention
- Musculoskeletal pain and rehabilitation
- Context-Aware Activity Recognition Systems
- Physical Activity and Health
- Wind and Air Flow Studies
- Trauma and Emergency Care Studies
- Protease and Inhibitor Mechanisms
- Synthesis of heterocyclic compounds
- Cyclone Separators and Fluid Dynamics
- Spine and Intervertebral Disc Pathology
- Human Mobility and Location-Based Analysis
- Occupational Health and Safety Research
- Hand Gesture Recognition Systems
National Taiwan University
2015-2021
National Taiwan University Hospital
2017-2021
National Yang Ming Chiao Tung University
2008-2015
National Yang Ming University Hospital
2014-2015
Taipei City Hospital
2010-2014
Abstract Diabetes mellitus (DM) is associated with higher risk of tendinopathy, which reduces tolerance to exercise and functional activities affects lifestyle glycemic control. Expression tendon-related genes matrix metabolism in tenocytes are essential for maintaining physiological functions tendon. However, the molecular mechanisms involved diabetic tendinopathy remain unclear. We hypothesized that high glucose (HG) alters characteristics tenocyte. Using vitro 2-week culture tenocytes, we...
The effects of low intensity pulsed ultrasound to tenocytes and osteocytes are well understood applied clinically. However, its on cultured Schwann cells still not elucidated. This study was designed elucidate the their possible molecular mechanism. were harvested from sciatic nerves 3-day-old Sprague-Dawley rats. Low stimulator (frequency: 1 MHz, duration: 2 min, duty cycle: 20%, total treatment time: 3 min) three different culture conditions: regular medium containing 0, 5, or 10% fetal...
Background: The purpose of the study was to compare morphomechanical and functional characteristics during maximal isometric, concentric, eccentric contractions in legs patients that underwent unilateral Achilles tendon repair with those their noninjured control legs. Methods: Twenty participants (median age = 38.2 years; range, 21.1-57.3 years) who between 3 12 months ago were recruited following measures: (1) mechanical stiffness aponeurosis (2) electromyography medial gastrocnemius...
Previous studies showed that multicomponent exercise enhanced physical and cognitive functions. This study aimed to investigate the effects of a on dual-task performance executive function demonstrate relationship between improvement in enhancement among elderly. A total 27 people completed intervention, with 16 experimental group 11 control group. The 12-week lasted 1 h per day 3 days week. Participants' gait was assessed conditions examined at both pre- post-intervention. Results...
Inflammation has been proposed to be an important causative factor in ligamentum flavum hypertrophy. However, the mechanisms of mechanical load on inflammation remain unclear. In this study, we used vitro model human fibroblasts subjected centrifugal force elucidate effects cultured fibroblasts; further studied its molecular and biochemical mechanisms. Human were obtained from six patients undergoing lumbar spine surgery. Monolayer cultures different magnitudes forces. Cell viability, cell...
Diabetes mellitus is associated with damage to tendons, which may result from cellular dysfunction in response a hyperglycemic environment. Tenocytes express diminished levels of tendon-associated genes under conditions. In contrast, mechanical stretch enhances tenogenic differentiation. However, whether hyperglycemia increases the non-tenogenic differentiation potential tenocytes and this can be mitigated by remains elusive. We explored vitro effects high glucose on rat primary tenocytes....
Background Return to work is an important outcome following traumatic work-related hand injuries. It unclear how psychosocial factors affect the time return injury.
The formation of fibrotic tissue in the ligamentum flavum (LF) is usually preceded by breakdown elastic fibers. Elastin-derived peptides (EDPs) from fibers display a wide range biological activities variety cells, but there minimal information regarding involvement processes LF hypertrophy. aim this study to elucidate effects EDPs on cultured human cells and investigate their molecular biochemical mechanisms. Human were obtained 18 patients who underwent lumbar spine surgery. After treatment...
Objectives: This case-control study aimed to investigate the predictors of return work (RTW) following work-related major forearm, wrist or hand injury at preparation stage work.Material and Methods: A total 80 clients were recruited divided into 2 groups depending on their readiness RTW.The compared with each other regard demographics, compensation status, severity, health perception, time off (TOW) using correlation coefficient.Predictors RTW measured by logistic regression...
Ultrasound is an effective noninvasive treatment for various tendinopathies. However, how tenocytes convert ultrasound stimulation into cascades of cellular and molecular events not well understood. The purpose this study to elucidate the signaling pathways during stimulation.Primary cultures were harvested from Achilles tendons Sprague–Dawley rats. viability proliferation tenocytes, their genes expression, after with or without specific inhibitors evaluated analyzed.The results showed that...
Mechanical load-induced osteogenic differentiation might be the key cellular event in calcification and ossification of ligamentum flavum. The aim this study was to investigate influence tissue transglutaminase (TGM2) on mechanical osteogenesis flavum cells. Human cells were obtained from 12 patients undergoing lumbar spine surgery. Osteogenic phenotypes cells, such as alkaline phosphatase (ALP), Alizarin red-S stain, gene expression makers evaluated following administration load BMP-2...
Background Advanced treatment of oral cancer increases survival rates; however, it also the risk developing shoulder dysfunction, dysphagia, donor site morbidity and psychological issues. This single-arm preliminary pilot study aims to explore effects a six-month early intervention program following reconstructive surgery in survivors. Methods A total 65 participants were analyzed surgery. Outcome measurements taken during first visit, at one, three six months after Results Scapular muscle...
Spinal accessory nerve dysfunction is one of the complications neck dissection in patients with oral cancer. This study aimed to explore effects long-term scapular-focused exercises and conscious control scapular orientation on movement quality life (QoL).This was a randomized controlled trial concealed allocation, assessor blinding, intention-to-treat analysis. Thirty-six cancer were randomly allocated motor-control group (scapular-focused exercise + orientation) or regular-exercise only)....