A5055944916- Blood transfusion and management
- Blood donation and transfusion practices
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Erythropoietin and Anemia Treatment
- Erythrocyte Function and Pathophysiology
- Antiplatelet Therapy and Cardiovascular Diseases
- Hemoglobinopathies and Related Disorders
- Venous Thromboembolism Diagnosis and Management
- Ocular Surface and Contact Lens
- Hematopoietic Stem Cell Transplantation
- Blood properties and coagulation
- Blood disorders and treatments
- Corneal Surgery and Treatments
- Helminth infection and control
- Inflammatory Biomarkers in Disease Prognosis
- Intravenous Infusion Technology and Safety
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Organ Donation and Transplantation
- Glaucoma and retinal disorders
- Cardiac Imaging and Diagnostics
- Heparin-Induced Thrombocytopenia and Thrombosis
- Inflammatory mediators and NSAID effects
- Parasite Biology and Host Interactions
Sanquin
2016-2025
Haga Hospital
2020-2025
Leiden University Medical Center
1981-2022
Jon J van Rood Centre for Clinical Transfusion Research
2012-2018
University of Amsterdam
2017
Immungenetics (Germany)
2017
Goethe University Frankfurt
2016
Medical University of Vienna
2016
University Hospital Frankfurt
2016
Institute for Transfusion Medicine
2016
Hemolysis of red blood cells (RBCs) during bank storage is the most obvious manifestation RBC system failure. However, its analysis made difficult because largest source interunit difference donor specific. Availability data from national systems on large numbers units used for internal quality control (QC) purposes and stored processed in uniform ways permits statistical analysis.Measures hemolysis at end randomly selected observed QC were obtained four systems. Groups these measures that...
The importance of a functional Krebs cycle for energy generation in the procyclic stage Trypanosoma brucei was investigated under physiological conditions during logarithmic phase growth pleomorphic parasite strain. Wild type cells and mutants with targeted deletion gene coding aconitase were derived by synchronous vitro differentiation from wild mutant (Delta aco::NEO/Delta aco::HYG) bloodstream parasites, respectively, where is not expressed dispensable. No differences intracellular levels...
The introduction of platelet (PLT) additive solutions (PASs) and pathogen reduction (PR) technologies possibly allow extension PLT shelf life. It was our aim to compare in vitro quality leucocyte-reduced concentrates (PCs) stored various PASs, including PR, with those plasma during 8 days storage. study performed four blood centres where each tested conditions.In paired experiments (n = 12), buffy coat pools were made which storage media added. Plasma served as reference; two used InterSol...
Summary The risk of acute cardiovascular events is highest during morning hours, and platelet activity peaks hours. effect timing aspirin intake on circadian rhythm peak reactivity not known. It was our objective to evaluate the reactivity. A randomised open-label cross-over trial in healthy subjects (n=14) conducted. Participants used acetylsalicylic acid (80 mg) awakening or at bedtime for two periods weeks, separated by a four-week wash-out period. At end both blood drawn every 3 hours...
The use of di-ethyl-hexyl-phthalate (DEHP) in medical devices will be banned the European Union from 1 July 2030, onwards. It is therefore important to evaluate performance non-DEHP blood collection system alternatives. Previously, we reported that red cell concentrates (RCCs) phosphate-adenine-glucose-guanosine-saline-mannitol (PAGGSM) stored containers did not result an increased transfusion reaction rate (TRR) as compared with saline-adenine-glucose-mannitol (SAGM)/DEHP-stored RCC....
Background and Objectives In a preliminary study, the presence of potassium magnesium in modified synthetic medium (PAS‐III) was found to have significant influence on platelet metabolism (using apheresis‐derived, as well buffy‐coat‐derived platelets) when compared with standard PAS‐III. The differences included reduced glycolysis, evidenced by lower consumption glucose production lactate, but also better preservation pH hypotonic shock response reactivity. results suggested that storage...
BACKGROUND: Storage of PLT concentrates (PCs) may be extended beyond 5 days, provided in‐vitro and in‐vivo variables allow longer storage bacterial screening is performed. The aim this study was to examine characteristics PCs in various solutions: plasma only, or mixtures with PAS‐II, PAS‐III, PAS‐IIIM, Composol. STUDY DESIGN AND METHODS: from five pooled buffy‐coats WBCs reduced by filtration were stored 1.3‐L butyryl‐tri‐hexyl‐citrate‐plasticised PVC containers. First, a paired comparison...
In Europe, red cell concentrates (RCC) are usually stored in SAGM (saline-adenine-glucose-mannitol). During storage, vitro quality declines, including lowered energy status and increased lysis. Recently, several additive solutions (ASs), designed to diminish the decline during have been developed. These new mainly developed better maintain blood (RBC) 2,3-biphosphoglycerate (2,3 BPG) levels storage. High of 2,3 BPG allow for oxygen release while high is necessary function survival RBC vivo....
Abstract Analytical measurements and proton nuclear magnetic resonance ( 1 H NMR) spectra of phenolic extracts were performed on a set italian extra‐virgin olive oils from different cultivars geographical locations Apulia region. Multivariate statistical analysis (principal component analysis, hierarchical clustering discriminant analysis) was applied separately to analytical NMR data. parameters, in particular fatty acid compositions, permit the discrimination variety, while data...
BACKGROUND: During storage at room temperature, platelets (PLTs) undergo several changes, a process known as PLT lesion. The pH is one of the variables changing and has been suggested to be good surrogate marker for quality concentrates. It unknown whether decrease such induces lesion or that deterioration PLTs results in decrease. In this study, responses applied values were investigated. STUDY DESIGN AND METHODS: washed three times additive solution (PAS‐IIIM) resuspended PAS‐IIIM buffers...
There is increasing international interest in producing components from blood that has been stored at room temperature for 24 hours. The lack of comprehensive data on the quality plasma produced this way led to study.A total 128 units whole were pooled groups four and split produce 32 sets identical processed either within 8 hours collection or after 24-hour storage 18 25°C.Storage resulted a 23% decrease activity Factor (F)VIII, but not significant loss coagulation factors FV, FVII, FXI,...
Background Recent studies showed that M irasol pathogen reduction treatment ( PRT ) leads to increased P ‐selectin expression and oxygen glucose consumption in resting platelets PLTs ). This study investigates the effect of on PLT activation. Study Design Methods Untreated or irasol‐treated were analyzed at different time points during storage. Microaggregation upon stimulation with phorbol myristate acetate PMA ), convulxin, ristocetin was measured. Alpha granule contents release thrombin...
Serum eye drops (SEDs) are used to treat a variety of ocular surface defects. normally produced from the patient's blood. However, not all patients can donate sufficient or suitable blood, and logistics be challenging. Allogeneic blood voluntary donors does have these disadvantages. Our aim was evaluate whether autologous allogeneic SEDs comparable efficacy tolerability.In prospective, double-blind crossover trial, with severe dry eyes were randomized first receive for one month, followed by...