A5059017136- Helminth infection and control
- Parasitic Diseases Research and Treatment
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Insects and Parasite Interactions
- Parasitic Infections and Diagnostics
- Coccidia and coccidiosis research
- Insect symbiosis and bacterial influences
- Erythrocyte Function and Pathophysiology
- Trypanosoma species research and implications
- Blood transfusion and management
- Hemoglobinopathies and Related Disorders
- Mollusks and Parasites Studies
- Plant and fungal interactions
- Complement system in diseases
- Microbial infections and disease research
- Vector-borne infectious diseases
- Blood groups and transfusion
- Insect Utilization and Effects
- Infectious Diseases and Mycology
- Neonatal Health and Biochemistry
- Veterinary Equine Medical Research
- Mosquito-borne diseases and control
- Research on Leishmaniasis Studies
- Forensic Entomology and Diptera Studies
Sanquin
2015-2025
Baton Rouge Clinic
2023
University of Amsterdam
2016-2020
Amsterdam University Medical Centers
2019
Louisiana State University
2008-2018
Amsterdam UMC Location University of Amsterdam
2017-2018
Louisiana State University Agricultural Center
1997-2009
University of Wisconsin–Madison
2008
University of Georgia
2003
Smith College
2002
Abstract Objective —To determine prevalence of anthelmintic resistance in cyathostome nematodes horses the southern United States. Design —Cross-sectional study. Animals —786 on 44 farms and stables Georgia, South Carolina, Florida, Kentucky, Louisiana. Procedure —Fecal egg count (FEC) reduction tests were performed large stables. Horses each farm treated with an oral paste formulation fenbendazole, oxibendazole, pyrantel pamoate, or ivermectin at recommended label dosages. A mixed linear...
Strains of Dirofilaria immitis suspected lack efficacy (LOE) to macrocyclic lactone (ML) preventive drugs have been increasingly reported in dogs by practicing veterinarians since 2005 the Lower Mississippi Delta region. If proven, and not controlled early stages, emergence ML drug resistance threatens become a widespread problem US that may limit effectiveness current treatment methods. To validate practice reports, statewide survey Louisiana was done define extent identify focal `hotspots'...
Renal ex vivo normothermic machine perfusion (NMP) is under development as an assessment tool for high-risk kidney grafts and a means of achieving more physiologically accurate organ preservation. On-going hemolysis has been reported during NMP, this technique relies on red blood cells oxygen delivery. In study, we confirm the occurrence progressive 6-hour NMP. NMP-associated erythrostasis in glomeruli peri-glomerular vascular networks points to interaction between graft. Continuous resulted...
Plasmodium falciparum and Trypanosoma cruzi were killed by two novel lytic peptides (SB-37 Shiva-1) in vitro. Human erythrocytes infected with P. falciparum, Vero cells T. cruzi, exposed to these peptides. The result, both cases, was a significant decrease the level of parasite infection. Furthermore, had marked cytocidal effect on trypomastigote stages T media, whereas host eukaryotic unaffected treatments. In view worldwide prevalence protozoan diseases lack completely suitable treatments,...
The ability of oral tetracycline to inhibit the development third-stage infective larvae (L3) Brugia pahangi adult worms in jirds was studied using 2 experimental protocols. Jirds treated with 1.4% drinking water for a period beginning 30 days before inoculation L3 until post-inoculation (DPI) had 97% reduction worm recovery compared untreated controls. that received 1.2% 1 day either 12 or 26 DPI recoveries 11% and < 1%, respectively. Untreated those given at later than 13 similar (27-29%)....
The use of di-ethyl-hexyl-phthalate (DEHP) in medical devices will be banned the European Union from 1 July 2030, onwards. It is therefore important to evaluate performance non-DEHP blood collection system alternatives. Previously, we reported that red cell concentrates (RCCs) phosphate-adenine-glucose-guanosine-saline-mannitol (PAGGSM) stored containers did not result an increased transfusion reaction rate (TRR) as compared with saline-adenine-glucose-mannitol (SAGM)/DEHP-stored RCC....
SUMMARY Nineteen purebred Beagles of various ages (4, 5, 13, and 47 weeks) were inoculated with North American Trypanosoma cruzi isolates obtained from an opossum (Tc-O), armadillo (Tc-A), or a dog (Tc-D). Dogs grouped on the basis clinical outcome infection. During acute stage disease, dogs group 1 (n = 7 Tc-O Tc-A) died euthanatized because severity disease. 2 5 developed but survived to develop chronic 3 Tc-Dinoculated dogs) neither nor 4 4—2 13 weeks old old) served as noninoculated...
The ability of a reverse line blot (RLB) assay to identify 13 common species equine small strongyles (cyathostomins) and discriminate them from three Strongylus spp. (large strongyles) was demonstrated. relied on the specific hybridization PCR-amplified intergenic spacer DNA fragments nuclear ribosomal membrane-bound species-specific probes. All cyathostomins examined were unequivocally identified simultaneously discriminated each other large (Strongylus edentatus, equinus, vulgaris). This...
SUMMARY The controlled test method was used to evaluate the antiparasitic efficacy of im inoculated 22,23-dihydroavermectin B 1 (ivermectin) against gastrointestinal parasites horses (ponies). Parasite infections were naturally acquired in southern Louisiana. Dose levels drug tested 0.2 mg/kg, 0.3 and 0.5 mg/kg. Ivermectin at all dose had an greater than 97% ( P < 0.05) Gasterophilus intestinalis larvae, Trichostrongylus axei, Oxyuris equi Strongylus vulgaris, S edentatus , 15 species...
Even though red blood cell (RBC) vesiculation is a well-documented phenomenon, notably in the context of RBC aging and transfusion, exact signalling pathways kinases involved this process remain largely unknown. We have established screening method for vesicle shedding using Ca2+ ionophore ionomycin which rapid efficient to promote vesiculation. In order identify novel stimulating RBC, we screened two libraries: Library Pharmacologically Active Compounds (LOPAC) Selleckchem Kinase Inhibitor...
Red blood cell (RBC) clearance is known to occur primarily in the spleen, and presumed be executed by red pulp macrophages. Erythrophagocytosis spleen takes place as part of homeostatic turnover RBCs remove old RBCs. It can strongly promoted immunoglobulin G (IgG) opsonization RBCs, a condition that consequence autoantibody or alloantibody formation. The purpose our study was investigate which phagocytes are involved IgG-mediated RBC human spleen. We developed highly specific vitro assay...
We have investigated the roles of gamma interferon (IFN-gamma) and interleukin-4 (IL-4) in host defense against Brugia malayi. Our data suggest that lack either IFN-gamma or IL-4 prolongs time required to achieve sterile immunity, suggesting both canonical type 1 2 responses are involved clearance infection.
One hundred and seventeen ponies were surveyed for the seasonal prevalence of strongyloid parasites, particularly cyathostomes, host- age-related differences in these infections. For 56 ponies, all stages cyathostome life cycle, both mucosal luminal, enumerated. Total numbers cyathostomes percentage developing larvae (DL) encysted mucosa remained constant 4 seasons year, whereas a significant increase adults population occurred fall. In yearling early third-stage constituted significantly...
The prevalence of Trypanosoma cruzi in 48 opossums and 98 armadillos from southern Louisiana was studied.Sixteen (33.3%) 1 armadillo (1.1%) were positive for T. by blood culture.Hearts 45 the tissues culture-positive available histopathological examination.Although histopathology revealed pseudocysts 6 opossums, 2 not on culture.Therefore, 18 (37.5%) cruzi.Twentytwo had histological evidence myocarditis.No lesion typical infection with observed tissues.These results substantiate that opossum...
Ponies reared with minimal or no exposure to anthelmintics were surveyed for intestinal helminths in order estimate prevalence and intensity of parasite populations unaltered by frequent anthelmintics. Thirty-seven mixed breed ponies varying ages examined. Thirty-four species nematodes 2 cestodes found. Twenty-four the nematode (including 1 new species) subfamily Cyathostominae (small strongyles). Eighty-seven percent total burden adult small strongyles large intestine was composed 10...