A5014960520- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Obsessive-Compulsive Spectrum Disorders
- Neurological disorders and treatments
- Pharmacological Receptor Mechanisms and Effects
- Functional Brain Connectivity Studies
- Bipolar Disorder and Treatment
- Circadian rhythm and melatonin
- Vagus Nerve Stimulation Research
- Attention Deficit Hyperactivity Disorder
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuroscience and Neural Engineering
- Stress Responses and Cortisol
- Schizophrenia research and treatment
- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Olfactory and Sensory Function Studies
- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
University of Ottawa
2015-2024
Royal Ottawa Mental Health Centre
2009-2024
Gedeon Richter (Hungary)
2018
Allergan (United States)
2018
Lundbeck (Denmark)
2015
Harvard University Press
2014
Boston University
2014
University of Pittsburgh
2014
Ottawa University
2009
Université Claude Bernard Lyon 1
1989-2007
Anatomical studies have established the existence of reciprocal relationships between main population monoamine, serotonin (5-HT), norepinephrine (NE) and dopamine (DA) neurons in brain. The present study was thus conducted to examine firing activity 5-HT NE DA-depleted rats, as well DA 5-HT- or NE-depleted rats. selective lesion elicited by 6-hydroxydopamine (6-OHDA) decreased spontaneous dorsal raphe (DR) nucleus 60%, revealing excitatory effect input on these neurons. In contrast,...
Abstract Vagus nerve stimulation (VNS) is an adjunctive treatment for resistant epilepsy and depression. Electrophysiological recordings in the rat brain have already shown that chronic VNS increases norepinephrine (NE) neuronal firing activity and, subsequently, of serotonin (5-HT) neurons through activation their excitatory α1-adrenoceptors. Long-term was to increase tonic post-synaptic 5-HT1A receptors hippocampus. This study aimed at examining effect on extracellular 5-HT, NE dopamine...
A decreased central dopaminergic and/or noradrenergic transmission is believed to be involved in the pathophysiology of depression. It known that dopamine (DA) neurons ventral tegmental area (VTA) and norepinephrine (NE) locus ceruleus (LC) are autoregulated by somatodendritic D<sub>2</sub>-like α<sub>2</sub>-adrenoceptors, respectively. Complementing these autoreceptor-mediated inhibitory feedbacks, anatomical functional studies have established a role for inputs regulating activity,...
The rapid antidepressant action of a subanesthetic dose ketamine in treatment-resistant patients represents the most striking recent breakthrough understanding response. Evidence demonstrates tight interactions between glutamatergic and monoaminergic systems. It is thus hypothesized that monoamine systems may play role immediate/rapid effects ketamine. In vivo electrophysiological recordings were carried male rats following administration (10 25 mg/kg, i.p.) to first assess its on neuron...
Clinical and preclinical studies have shown that the effect of citalopram on serotonin (5-HT) reuptake inhibition its antidepressant activity resides in S-enantiomer. In addition, using a variety in-vivo in-vitro paradigms, it was R-citalopram counteracts escitalopram. This suggested to occur via an allosteric modulation at level 5-HT transporter. Using binding assays membranes from COS-1 cells expressing human transporter (hSERT) electrophysiological microdialysis techniques rats, present...