A5056180679- Olfactory and Sensory Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology and Insect Physiology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Biochemical Analysis and Sensing Techniques
- Advanced Chemical Sensor Technologies
- Hearing Loss and Rehabilitation
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Psychoanalysis and Psychopathology Research
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Neurological Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Nutrition and Health in Aging
- Clinical Nutrition and Gastroenterology
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroscience and Neuropharmacology Research
- Sarcoidosis and Beryllium Toxicity Research
- Allergic Rhinitis and Sensitization
- French Urban and Social Studies
- Multisensory perception and integration
Centre National de la Recherche Scientifique
2010-2024
Université Claude Bernard Lyon 1
2013-2024
Centre de Recherche en Neurosciences de Lyon
2014-2024
Inserm
2014-2024
Institut de Biologie Valrose
2024
Université Côte d'Azur
2024
Laboratoire Jean-Alexandre Dieudonné
2024
Institut Universitaire de France
2021-2024
Canadian Nautical Research Society
2024
HES-SO University of Applied Sciences and Arts Western Switzerland
2024
Perceptual learning is required for olfactory function to adapt appropriately changing odor environments. We here show that newborn neurons in the bulb are not only involved in, but necessary for, perceptual learning. First, discrimination of perceptually similar odorants improves mice after repeated exposure odorants. Second, this improved accompanied by an elevated survival rate inhibitory neurons, preferentially processing learned odor, within bulb. Finally, blocking neurogenesis before...
Inhibitory interneurons of the olfactory bulb are subjected to permanent adult neurogenesis. Their number is modulated by learning, suggesting that they could play a role in plastic changes bulbar network associated with memory. Adult male C57BL/6 mice were trained an associative task, and we analyzed long-term retention task 5, 30, 90 d post-training. In parallel, assessed fate these newborn cells, mapped their distribution measured functional implication using immediate early gene Zif268....
One major unresolved problem in olfaction research is to relate the percept molecular structure of stimuli. The present study examined this issue and showed for first time a quantitative structure-odor relationship which more structurally complex monomolecular odorant, numerous olfactory notes it evokes. Low-complexity odorants were also rated as aversive, reflecting fact that low complexity may serve warning cue system. Taken together, these findings suggest provides framework explain...
Brain functional and structural changes lead to cognitive decline during aging, but a high level of stimulation life can improve performances in the older adults, forming reserve. Noradrenaline has been proposed as molecular link between environmental constitution Taking advantage ability olfactory activate noradrenergic neurons locus coeruleus, we used repeated enrichment sessions over mouse lifespan enable reserve buildup. Mice submitted enrichment, whether started early or late adulthood,...
In the main olfactory bulb, stimuli are coded within spatio-temporal pattern of mitral cells' activity. Granule cells interneurons that shape activity, and continuously generated in adult bulb. However, role granule cell renewal remains elusive. We show here an associative discrimination task reduces survival newborn neurons. when involves perceptually related odorants, learning process is slower does not induce such a reduction number new Mapping layer bulb reveals clustered distribution...
In humans, the pleasantness of odors is a major contributor to social relationships and food intake. Smells evoke attraction repulsion responses, reflecting hedonic value odorant. While olfactory preferences are known be strongly modulated by experience learning, it has been recently suggested that, in may partly explained physicochemical properties odorant molecules themselves. If odor indeed predetermined structure, then could hypothesized that other species will show similar humans....
We have previously shown that an experience-driven improvement in olfactory discrimination (perceptual learning) requires the addition of newborn neurons bulb (OB). Despite this advance, mechanisms which govern selective survival OB following learning remain largely unknown. propose activity noradrenergic system is a critical mediator providing top-down signal to control newly born cells and support perceptual learning. In adult mice, we used pharmacological means manipulate neurogenesis...
Noradrenergic projections from the locus coeruleus (LC) project to olfactory bulb (OB), a cortical structure implicated in odor learning and perceptual differentiation among similar odorants. The authors tested role of OB noradrenaline (NA) short-term memory using an animal model LC degeneration coupled with intrabulbar infusions NA. Specifically, lesioned noradrenergic fibers mice neurotoxin N-Ethyl-N-(2-chloroethyl)-2-bromobenzylamine hydrochloride (DSP4) measured effects on...
New neurons are continuously generated in the adult mammalian olfactory bulb. The role of these newborn learning has been debated. Blocking addition reported either to result memory alteration or have no effect at all (Imayoshi et al., 2008; Breton-Provencher 2009; Lazarini Sultan 2010). These discrepancies may arisen from differences behavioral paradigms used: operant procedures indicated that neurogenesis blockade had substantial effects on long-term (Lazarini 2010) whereas other methods...
Neuronal synchronization in the olfactory bulb has been proposed to arise from a diffuse action of glutamate released mitral cells (MC, relay neurons). According this hypothesis, spills over dendrodendritic synapses formed between MC and granule (GC, interneurons) activate neighboring MC. The excitation is balanced by strong inhibition GC. Here we show that caused bulbar interneurons located GC layer. These reciprocal depend on an unusual, 2-amino-5-phosphonovaleric acid-resistant, N...
Sensory neural activity is highly context dependent and shaped by experience expectation. In the olfactory bulb (OB), first cerebral relay of processing, responses to odorants are previous experiences including contextual information thanks strong feedback connections. present experiment, mice were conditioned associate an odorant with a visual then exposed alone. We found that alone elicited exploration odor port similar stimulus when it was initially presented. OB, activation pattern,...
Neural stem cells (NSC) persist in the adult mammalian brain, within subventricular zone (SVZ). The endogenous mechanisms underpinning SVZ and progenitor cell proliferation are not fully elucidated. Vitamin K-dependent proteins (VKDPs) mainly secreted factors that were initially discovered as major regulators of blood coagulation. Warfarin ((S(-)-3-acetonylbenzyl)-4-hydroxycoumarin)), a widespread anticoagulant, is vitamin K antagonist inhibits production functional VKDP. We demonstrate...
A role for newborn neurons in olfactory memory has been proposed based on learning-dependent modulation of bulb neurogenesis adults. We hypothesized that if support memory, then they should be suppressed by erasure. Using an ecological approach mice, we showed behaviorally breaking a previously learned odor-reward association prematurely selected to survive during initial learning. Furthermore, intrabulbar infusions the caspase pan-inhibitor ZVAD (benzyloxycarbonyl-Val-Ala-Asp) behavioral...