A5028428393- Olfactory and Sensory Function Studies
- Neurobiology and Insect Physiology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Biomedical Text Mining and Ontologies
- Neurogenesis and neuroplasticity mechanisms
- Memory and Neural Mechanisms
- Biochemical Analysis and Sensing Techniques
- Semantic Web and Ontologies
- Natural Language Processing Techniques
- Mental Health and Psychiatry
- Axon Guidance and Neuronal Signaling
- Health, Medicine and Society
- Photoreceptor and optogenetics research
- Nerve injury and regeneration
- Hemoglobinopathies and Related Disorders
- Pain Management and Placebo Effect
- Data Quality and Management
- Pain Mechanisms and Treatments
- Rough Sets and Fuzzy Logic
- Topic Modeling
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
- Pathogenesis and Treatment of Hiccups
- African Studies and Ethnography
- Iron Metabolism and Disorders
Fondation de France
2025
Inserm
2014-2024
Université Claude Bernard Lyon 1
2009-2024
Centre de Recherche en Neurosciences de Lyon
2013-2024
Canadian Nautical Research Society
2024
Centre Hospitalier Le Vinatier
2016-2023
Centre National de la Recherche Scientifique
2005-2021
Laboratoire de psychologie: dynamiques relationnelles et processus identitaires
2018
Université Sorbonne Paris Nord
2015-2017
Sorbonne Université
2013-2017
Little is known about how normal aging affects the brain. Recent evidence suggests that neuronal loss not ubiquitous in neocortex. Instead, subtle and still controversial, region- layer-specific alterations of neuron morphology synapses are reported during aging, leading to notion discrete changes neural circuitry may underlie age-related cognitive deficits. Although deficits sensory function suggest primary cortices affected by our understanding cellular molecular sparse. To assess effect...
Brain functional and structural changes lead to cognitive decline during aging, but a high level of stimulation life can improve performances in the older adults, forming reserve. Noradrenaline has been proposed as molecular link between environmental constitution Taking advantage ability olfactory activate noradrenergic neurons locus coeruleus, we used repeated enrichment sessions over mouse lifespan enable reserve buildup. Mice submitted enrichment, whether started early or late adulthood,...
The piriform cortex (PCX) is a trilaminar paleocortex that of interest for its role in odor coding and as model studying general principles cortical sensory processing. While the structure mature PCX has been well characterized, development poorly understood. Notably, kinetics cellular morphological basis postnatal events shape remain unknown. We followed fates early- versus late-born cells layer II anterior PCX, with focus on molecular maturation pyramidal their differentiation. showed...
Both passive exposure and active learning through reinforcement enhance fine sensory discrimination abilities. In the olfactory system, this enhancement is thought to occur partially integration of adult-born inhibitory interneurons resulting in a refinement representation overlapping odorants. Here, we identify mice novel unexpected dissociation between at level granule cells. Specifically, while both processes augment neurogenesis, cells differ their morphology, functional coupling thus...
Olfactory perceptual learning is defined as an improvement in the discrimination of perceptually close odorants after passive exposure to these odorants. In mice, simple olfactory involving two depends on increased number adult-born neurons bulb, which refines bulbar output. However, environment complex, raising question adjustment network multiple challenges. Perceptual 1 6 pairs similar led all learned odor pairs. Increasing complexity did not increase neuron survival but enhanced...
Hedonic perception deeply changes with aging, significantly impacting health and quality of life in elderly. In young adult mice, an odor hedonic signature is represented along the antero-posterior axis olfactory bulb, transferred to tubercle ventral tegmental area, promoting approach behavior. Here, we show that while unattractive odorants was unchanged older mice (22 months), appreciation some but not all attractive declined. Neural activity bulb consistently altered when attraction...
Abstract The major impediments to axonal regeneration in the central nervous system are growth‐inhibitory proteins present myelin sheath, and Nogo‐A is one of most potent inhibitors synthesized by oligodendrocytes. However, neuronal expression during development suggests that it may have an additional role. spatio‐temporal regulation both mRNA protein was examined situ hybridization immunohistochemistry developing rat olfactory system. During embryonic postnatal (from E13 P6), were strongly...
Noradrenaline contributes to olfactory-guided behaviors but its role in olfactory learning during adulthood is poorly documented. We investigated implication associative and perceptual using local infusion of mixed α1-β adrenergic receptor antagonist (labetalol) the adult mouse bulb. reported that learning, as opposed was not affected by labetalol infusions Accordingly, this treatment did affect survival bulbar adult-born neurons. Altogether, our results suggest noradrenergic system plays...
Abstract Adult olfactory neurogenesis provides waves of new neurons involved in memory encoding. However, how the bulb deals with neuronal renewal to ensure persistence pertinent memories and flexibility integrate events remains unanswered. To address this issue, mice performed two successive discrimination learning tasks varying times between tasks. We show that a short time tasks, adult-born supporting first task appear be highly sensitive interference. Furthermore, targeting these using...
We propose a modular approach to develop an ontology of psychiatry, ONTOPSYCHIA, based on Patient Discharges Summaries (PDS) and divided into three modules (i.e. social, mental disorders treatments). decided take account the social aspects patient life described in PDS consider information such as family history, environment or education.
In the mouse olfactory system regulated expression of a large family G Protein-Coupled Receptors (GPCRs), Odorant (ORs), provides each sensory neuron with single OR identity. wiring projections, complex axon sorting process ensures segregation >1,000 subpopulations axons same identity into homogeneously innervated glomeruli. ORs are critical determinants in sorting, and their presence on raises intriguing possibility that they may participate axonal through direct or indirect...
Memory stability is essential for animal survival when environment and behavioral state change over short or long time spans. The of a memory can be expressed by its duration, perseverance conditions as well specificity to the learned stimulus. Using optogenetic pharmacological manipulations in male mice, we show that presence noradrenaline olfactory bulb during acquisition renders memories more stable. We while inhibition transmission an odor–reward has no acute effects, it alters...
ABSTRACT Normal brain aging is accompanied by functional and structural changes, leading to cognitive decline. A high level of stimulation during life associated with improved performances in elderly, forming the so-called reserve whose cellular mechanisms remain largely unknown. Noradrenaline has been proposed as a molecular link between environmental constitution reserve. Taking advantage ability olfactory trigger noradrenaline release, we used repeated enrichment sessions distributed over...
Psychiatry aims at detecting symptoms, providing diagnoses and treating mental disorders. We developed ONTOPSYCHIA, an ontology for psychiatry in three modules: social environmental factors of disorders, treatments. The use associated with dedicated tools, will facilitate semantic research Patient Discharge Summaries (PDS). To develop the first module we propose a PDS text analysis order to explicit concepts. decided set aside classifications during construction modu le, focus only on...
Pleasant odorants are represented in the posterior olfactory bulb (pOB) mice. How does this hedonic information generate odor-motivated behaviors? Using optogenetics, we here report that stimulating representation of pleasant a sensory structure, pOB, can be rewarding, self-motivating and is accompanied by ventral tegmental area activation. To explore underlying neural circuitry downstream OB, use 3D high-resolution imaging determine pOB preferentially projects to tubercle, whose activity...