A5082015350- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- RNA Research and Splicing
- bioluminescence and chemiluminescence research
- Genomics and Chromatin Dynamics
- Developmental Biology and Gene Regulation
- Cardiomyopathy and Myosin Studies
- Advanced Fluorescence Microscopy Techniques
- Wnt/β-catenin signaling in development and cancer
- Neurobiology and Insect Physiology Research
- Tendon Structure and Treatment
- Plant Molecular Biology Research
- Chromosomal and Genetic Variations
- Cellular transport and secretion
- Muscle Physiology and Disorders
- Lipid metabolism and biosynthesis
- Protein Kinase Regulation and GTPase Signaling
- Planarian Biology and Electrostimulation
- CRISPR and Genetic Engineering
- Heat shock proteins research
- Invertebrate Immune Response Mechanisms
- Microtubule and mitosis dynamics
Centre National de la Recherche Scientifique
2007-2025
Aix-Marseille Université
2023-2025
Institut de Biologie du Développement Marseille
2020-2024
The Francis Crick Institute
2019-2021
MRC Laboratory of Molecular Biology
2016-2019
Medical Research Council
2017
The Honourable Society of Lincoln's Inn
2009-2013
Cancer Research UK
2009-2013
Université Paris Cité
2007-2009
Institut Jacques Monod
2007-2009
Article5 May 2021Open Access Source DataTransparent process Wnt and Src signals converge on YAP-TEAD to drive intestinal regeneration Oriane Guillermin orcid.org/0000-0002-5819-1626 Epithelial Biology Laboratory, Francis Crick Institute, London, UK Stem Cell Cancer Search for more papers by this author Nikolaos Angelis Clara M Sidor Rachel Ridgway Colorectal signalling Research Beatson Glasgow, Anna Baulies Kucharska Pedro Antas Melissa R Rose Julia Cordero Institute of Sciences, Wolfson...
The study of P-element repression in Drosophila melanogaster led to the discovery telomeric Trans-Silencing Effect (TSE), a mechanism by which transposon or transgene inserted subtelomeric heterochromatin (Telomeric Associated Sequence TAS) has capacity repress trans female germline, homologous transposon, located euchromatin. TSE shows variegation among egg chambers ovaries when silencing is incomplete. Here, we report that displays an epigenetic transmission through meiosis, involves...
The myosin II activator Rho-kinase (Rok) is planar polarized at the tissue boundary of Drosophila embryonic salivary gland placode through a negative regulation by apical polarity protein Crumbs that anisotropically localized boundary. However, in inner cells placode, both and Rok are isotropically enriched junctions. We propose modulation membrane residence time Crumbs' downstream effectors can reconcile behaviors. Using FRAP combined with silico simulations, we find lower dissociation rate...
Mask family proteins were discovered in Drosophila to promote the activity of transcriptional coactivator Yorkie (Yki), sole fly homolog mammalian YAP (YAP1) and TAZ (WWTR1). The molecular function Mask, or its homologs Mask1 (ANKHD1) Mask2 (ANKRD17), remains unclear. contain two ankyrin repeat domains that bind Yki/YAP as well a conserved nuclear localisation sequence (NLS) export (NES), suggesting role nucleo-cytoplasmic transport. Here we show acts import Yki, addition an ectopic NLS Yki...
SUMMARY The cytoskeletal protein actin is crucial for cell shape and integrity throughout eukaryotes. Actin filaments perform essential biological functions, including muscle contraction, division tissue morphogenesis. These diverse activities are achieved through the ability of to be arranged into architectures, but a detailed appreciation dynamic organizational state has been hindered by available tools. Fluorescence polarization microscopy uniquely placed measuring organization exploiting...
Voluntary movement in animals is driven by the contraction of myofibrils striated muscle cells, which are linear chains regular cytoskeletal units termed sarcomeres. While ordered structure mature sarcomeres, key to contraction, well established, physical mechanism governing sarcomere assembly still under debate. Here we put forward a theory self-assembly based on data. We measured sequential ordering components developing flight muscles, using novel tracking-free algorithm. find that myosin...
Summary Rho-kinase (Rok) is a major myosin II activator during morphogenesis. In the Drosophila embryonic salivary gland placode Rok planar polarised at tissue boundary, through negative regulation by apical polarity protein Crumbs that anisotropically localised boundary. However, in inner cells of both and are isotropically enriched junctions. We propose model reconciles behaviours modulation membrane residence time downstream effectors. Using FRAP embryos expressing endogenously-tagged...
Neural stem cells or neuroblasts in the Drosophila melanogaster embryo delaminate as single from embryonic epidermis to give rise nervous system. Using this accessible system examine molecular mechanisms of cell ingression at a high temporal and spatial resolution, issue, Simões et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608038) reveal that myosin-driven anisotropic junction loss apical constriction are main drivers process.
Myofibrils in striated muscle cells are chains of regular cytoskeletal units termed sarcomeres, whose contractions drive voluntary movements animals. Despite the well characterized order sarcomere components mature which explains contraction mechanism, mechanism molecular ordering during assembly remains debated. Here, we put forward a theoretical framework for self-assembly sarcomeres. This theory is based on measurements sequential developing Drosophila flight muscles, identified by...
Abstract The Mask family of multiple ankyrin repeat and KH domain proteins were discovered in Drosophila to promote the activity transcriptional coactivator Yorkie (Yki), sole fly homolog mammalian YAP (YAP1) TAZ (WWTR1). molecular function Mask, or its homologs Mask1 (ANKHD1) Mask2 (ANKRD17), remains unclear. contain two Ankyrin domains that bind Yki/YAP as well a conserved nuclear localisation sequence (NLS) export (NES), suggesting role nucleo-cytoplasmic transport. Here we show acts...