A5103030245- Nail Diseases and Treatments
- Inflammasome and immune disorders
- Dermatology and Skin Diseases
- Chromatin Remodeling and Cancer
- NF-κB Signaling Pathways
- Bee Products Chemical Analysis
- Galectins and Cancer Biology
- Melanoma and MAPK Pathways
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Renal cell carcinoma treatment
- Psoriasis: Treatment and Pathogenesis
- Mechanisms of cancer metastasis
- Cancer-related Molecular Pathways
- PARP inhibition in cancer therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Mechanisms and Therapy
Institute of Molecular and Cell Biology
2018-2023
Agency for Science, Technology and Research
2018-2023
Human NLRP1 (NACHT, LRR, and PYD domain-containing protein 1) is an innate immune sensor predominantly expressed in the skin airway epithelium. Here, we report that human senses ultraviolet B (UVB)- toxin-induced ribotoxic stress response (RSR). Biochemically, RSR leads to direct hyperphosphorylation of a human-specific disordered linker region (NLRP1 DR ) by MAP3K20/ZAKα kinase its downstream effector, p38. Mutating single ZAKα phosphorylation site abrogates UVB- ribotoxin-driven pyroptosis...
Malassezia form the dominant eukaryotic microbial community on human skin. The genus possesses a repertoire of secretory hydrolytic enzymes involved in protein and lipid metabolism which alter external cutaneous environment. exact role most secreted enzymes, including those interaction with epithelial surface, is not well characterized. In this study, we compared expression level proteases, lipases, phospholipases, sphingomyelinases globosa healthy subjects seborrheic dermatitis or atopic...
Somatic and germline gain-of-function point mutations in RAF, one of the first oncogenes to be discovered humans, delineate a group tumor-prone syndromes known as RASopathies. In this study, we document human phenotype resulting from loss-of-function proto-oncogene RAF1 (a.k.a. CRAF). consanguineous family, uncovered homozygous p.Thr543Met variant segregating with neonatal lethal syndrome cutaneous, craniofacial, cardiac, limb anomalies. Structure-based prediction functional tests using...
Abstract S1.3 Malassezia: genetics, genomics, and biology, September 21, 2022, 11:00 AM - 12:30 PM Objectives Malassezia forms the dominant eukaryotic microbial community on human skin. The genus possesses a repertoire of secretory hydrolytic enzymes involved in protein lipid metabolism which alter external cutaneous environment. exact role most secreted enzymes, including those interaction with epithelial surface, is not well characterized. Methods Results In this study, we compared...