A5043251473- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- International Relations and Autism
- Urinary Bladder and Prostate Research
- Peroxisome Proliferator-Activated Receptors
- Immune Response and Inflammation
- Proteoglycans and glycosaminoglycans research
- Neuropeptides and Animal Physiology
- Nationalism and Cultural Identity
- Stress Responses and Cortisol
- Sphingolipid Metabolism and Signaling
- RNA modifications and cancer
- Sexual function and dysfunction studies
- Neurogenesis and neuroplasticity mechanisms
- Nuclear Receptors and Signaling
- Dermatology and Skin Diseases
Universitat Autònoma de Barcelona
2019-2024
Centro de Investigación Biomédica en Red
2022
Biomedical Research Networking Center on Neurodegenerative Diseases
2022
Universitat Pompeu Fabra
2019
Leigh syndrome is a mitochondrial disease characterized by neurodegeneration, neuroinflammation, and early death. Mice lacking NDUFS4, complex I subunit (Ndufs4 KO mice), have been established as good animal model for studying human pathology associated with syndrome. As the progresses, there an increase in neurodegeneration thereby leading to deteriorating neurological symptoms, including motor deficits, breathing alterations, eventually, death of animal. However, despite magnitude...
Interleukin-6 dysregulation has been implicated in the pathological progression of Alzheimer's disease (AD), a leading cause dementia ageing population. Here we show that chronic neuroinflammation elicited by transgenic expression IL-6 and systemic deficiency influences phenotype Tg2576 mouse model AD, modulating mortality, body weight, behavioral cognitive traits, amyloidosis, neuroinflammation. While conventional understanding AD pathophysiology emphasizes central role Amyloid beta;...
Traumatic brain injury (TBI) is a major health problem with high rates of mortality and morbidity worldwide. The response the to TBI orchestrated by number cytokines, including interleukin-6 (IL-6). IL-6 cytokine in central nervous system it produced different cells, such as neurons, glial endothelial cells. Since cells are one most important sources targets IL-6, we have examined role microglia-derived normal conditions following model TBI, cryolesion somatosensorial cortex. To this end,...
Abstract Background Mitochondrial diseases (MDs) are genetic disorders characterized by dysfunctions in mitochondria. Clinical data suggest that additional factors, beyond genetics, contribute to the onset and progression of this group diseases, but these influencing factors remain largely unknown. Mounting evidence indicates immune dysregulation or distress could play a role. observations have described co-incidence infection disease as well worsening symptoms following infection. These...
<b><i>Background/Aims:</i></b> The term vulvodynia refers to vulvar pain of unknown origin lasting at least 3 months. Psychiatric comorbidities are a common feature and, along with pain, may severely affect patients’ wellbeing. We aimed determine the characteristics in vulvodynia, correlate symptoms anxiety and depression, analyse impact these factors on quality life. <b><i>Methods:</i></b> This cross-sectional observational study analysed...
Perineuronal nets (PNNs) are a specialized extracellular matrix that have been extensively studied in the brain. Cortical PNNs implicated synaptic stabilization, plasticity inhibition, neuroprotection, and ionic buffering. However, role of spinal PNNs, mainly found around motoneurons, is still unclear. Thus, goal this study to elucidate on motor function both intact cord injured mice. We used transgenic mice lacking cartilage link protein 1 (Crtl1 KO mice), which PNN assembly. Crtl1 showed...