A5057916596- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Innovation and Socioeconomic Development
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant Reproductive Biology
- Hypothalamic control of reproductive hormones
- Genetic Syndromes and Imprinting
- Virus-based gene therapy research
University of Cambridge
2016-2020
Kisspeptin neuropeptides are encoded by the Kiss1 gene and play a critical role in regulation of mammalian reproductive axis. neurones found two locations rodent hypothalamus: one arcuate nucleus ( ARC ) another RP 3V region, which includes anteroventral periventricular AVPV ). Detailed mapping fibre distribution will help with our understanding action these other regions brain. We have generated transgenic mouse coding region is disrupted CRE ‐ GFP transgene so that expression recombinase...
Mouse embryonic stem cells (ESCs) have played a crucial role in biomedical research where they can be used to elucidate gene function through the generation of genetically modified mice. A critical requirement for success this technology is ability ESCs contribute viable chimaeras with germ-line transmission allele. We identified several ESC clones that cause death at mid late gestation stages. These had normal karyotype, were pathogen free and their vitro differentiation potential was not...