A5061151300- Hypothalamic control of reproductive hormones
- Plant Reproductive Biology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Neuroendocrine regulation and behavior
- Pregnancy and preeclampsia studies
- Adipose Tissue and Metabolism
- Neuropeptides and Animal Physiology
- Complement system in diseases
- Iron Metabolism and Disorders
- Anodic Oxide Films and Nanostructures
- Hemoglobinopathies and Related Disorders
University of Cambridge
2013-2019
Kisspeptin neuropeptides are encoded by the Kiss1 gene and play a critical role in regulation of mammalian reproductive axis. neurones found two locations rodent hypothalamus: one arcuate nucleus ( ARC ) another RP 3V region, which includes anteroventral periventricular AVPV ). Detailed mapping fibre distribution will help with our understanding action these other regions brain. We have generated transgenic mouse coding region is disrupted CRE ‐ GFP transgene so that expression recombinase...
Kisspeptins are a family of overlapping neuropeptides encoded by the Kiss1 gene that regulate mammalian reproductive axis central action in hypothalamus to stimulate GnRH release. and their receptor (GPR54 also called KISS1R) expressed testes but functional role this tissue has not been confirmed. We examined which cell types kisspeptin its staining for β-galactosidase activity using from transgenic mice with LacZ targeted either or Gpr54 genes. Expression both genes appeared be restricted...
The normal function of the mammalian reproductive axis is strongly influenced by physiological, metabolic and environmental factors. Kisspeptin neuropeptides, encoded Kiss1 gene, are potent regulators stimulating gonadodropin releasing hormone secretion from hypothalamus. To understand how modulated higher order neuronal inputs we have mapped afferent circuits into arcuate (ARC) neurons. We used a transgenic mouse that expresses CRE recombinase in neurons for conditional viral tracing with...
The Mfsd14a gene, previously called Hiat1, encodes a transmembrane protein of unknown function with homology to the solute carrier family. To study MFSD14A protein, mutant mice (Mus musculus, strain 129S6Sv/Ev) were generated gene disrupted LacZ reporter gene. Homozygous are viable and healthy, but males sterile due 100-fold reduction in number spermatozoa vas deferens. Male have adequate levels testosterone show normal copulatory behaviour. few that formed rounded head defects similar those...
Key points Neurons in the hypothalamus of brain which secrete peptide kisspeptin are important regulators reproduction, and normal reproductive development. Electrical activity, form action potentials, or spikes, leads to secretion peptides neurotransmitters, influencing activity downstream neurons; neurons, this is highly irregular, but mechanism not known. In study, we show that irregularity depends on presence a particular type potassium ion channel membrane, opens transiently response...
Kisspeptins, encoded by the Kiss1 gene, are a set of related neuropeptides that required for activation mammalian reproductive axis at puberty and to maintain fertility. In addition, kisspeptin signaling via G-protein coupled receptor GPR54 (KISS1R) has been suggested regulate human placental formation correlations have found between altered levels in maternal blood development pre-eclampsia.We used Gpr54 mutant mice investigate role structure function mouse placenta.Expression was confirmed...
Our previous study reported the expression of kisspeptin in preoptic area (POA) and arcuate nucleus (ARC) hypothalamus cycling buffalo cows. In ruminants, POA ARC are main hypothalamic nuclei through which acts on hypothalamic-pituitary-gonadal axis, due to their stimulation gonadotropin releasing hormone (GnRH) secretion. many species, activates GnRH neurons via its receptors (KISS1R or GPR54). The present was designed explore KISS1R by cow brains double-labeling immunohistochemistry. both...
Patients presenting with diabetes insipidus (DI) and subtle pituitary-stalk thickening on MRI represent a management challenge. LCH germinoma work-up (including serum/CSF AFP/HCG) is usually negative, given the poor sensitivity of these tests. Risks neurosurgical biopsy in such cases often outweigh perceived benefits. Consequently, only performed for radiological progression. This suboptimal approach may cause diagnostic delay inferior outcomes. Non-invasive microRNA testing malignant germ...
Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)
Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)