A5061298783- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Photodynamic Therapy Research Studies
- Synthesis and biological activity
- Nanoplatforms for cancer theranostics
- Synthesis and bioactivity of alkaloids
- Synthesis of Organic Compounds
- Porphyrin and Phthalocyanine Chemistry
- Cancer Research and Treatments
- Photoacoustic and Ultrasonic Imaging
- Neutropenia and Cancer Infections
- Synthesis and Biological Evaluation
- Medicinal Plants and Neuroprotection
- Skin Protection and Aging
- Carbohydrate Chemistry and Synthesis
- Immune Cell Function and Interaction
- Retinoids in leukemia and cellular processes
- Natural Antidiabetic Agents Studies
- Tuberculosis Research and Epidemiology
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Medicinal Plants and Bioactive Compounds
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
Bio Pharm Dongsung (South Korea)
2022-2024
Florida International University
2024
Yeungnam University
2014-2021
Photodynamic therapy (PDT) can eradicate not only cancer cells but also stimulate an antitumor immune response. Herein, we describe two efficient synthetic methodologies for the preparation of Chlorin e6 (Ce6) from Spirulina platensis and address phototoxic effect Ce6 in vitro along with activity vivo. Melanoma B16F10 were seeded phototoxicity was monitored by MTT assay. The C57BL/6 mice subcutaneously inoculated on left right flank cells. intravenously injected 2.5 mg/kg then exposed to red...
Our study aimed to explore the impact and mechanism of Euonymus alatus leaf extract on age-dependent oxidative stress, neuroinflammation, progressive memory impairments in aged mice. Twenty-four-month-old mice received EA-L3 (300 mg/kg/day) or reference drug, donepezil (DPZ, 5 mg/kg/day), for 6 weeks, learning functions were detected using Passive Avoidance Test (PAT). As expected, cognitive function deficits compared with young mice, these significantly mitigated by dietary treatments...
Skin photoaging due to ultraviolet B (UVB) exposure generates reactive oxygen species (ROS) that increase matrix metalloproteinase (MMP). Chlorin e6-photodynamic therapy (Ce6-PDT), in addition being the first-line treatment for malignancies, has been shown lessen skin photoaging, while curcumin is well known reducing deleterious effects of ROS. In current study, PDT with three novel Ce6-curcumin derivatives, a combination Ce6 and various linkers, including propane-1,3-diamine...
To identify the vascular alteration by photodynamic therapy (PDT), utilization of high-resolution, high-speed, and wide-field photoacoustic microscopy (PAM) has gained enormous interest. The rapid changes in vasculature during PDT treatment monitoring tumor tissue activation orthotopic pancreatic cancer model have received limited attention previous studies. Here, a fully two-axes waterproof galvanometer scanner-based (WGS-PAM) system was developed for vivo dynamic variations micro blood...
Novel series of chlorin e6-curcumin derivatives were designed and synthesized. All the synthesized compounds 16, 17, 18, 19 tested for their photodynamic treatment (PDT) efficacy against human pancreatic cancer cell lines: AsPC-1, MIA-PaCa-2, PANC-1. The cellular uptake study was performed in aforementioned lines using fluorescence-activated sorting (FACS). among with IC50 values 0.27, 0.42, 0.21 µM MIA PaCa-2, PANC-1 lines, respectively, demonstrated excellent internalization capability...
This work aims to prepare pure Chlorin e6 (Ce6) and establish Ce6-mediated photodynamic therapy (Ce6-PDT) as a better option for canine tumors well mouse tumor models. Five dogs suffering from various cancers were treated with Ce6-PDT one several times. After receiving the Ce6 (2.5 mg/kg) 3 h, illuminated superficially or interstitially 660 nm light. Two underwent Ce6-guided fluorescence imaging by diagnosis (PDD). Cell proliferation apoptosis detected 4,5-dimethylthiazol-2-yl)-2,5-diphenyl...
In the current study, therapeutic and preventive effects of Euonymus alatus (EA) twig extract were investigated in a mouse model cognitive deficit B35 cells. Twig 1 was extracted with 70% ethanol later 2 through liquid-liquid extraction hexane. EA (300 mg/kg) along standard drug donepezil (5 orally administered to mice for 34 days. Scopolamine given intraperitoneally 7 Administration significantly improved passive avoidance test (PAT) mice. twigs also restored scopolamine-reduced...
Photodynamic therapy and photoacoustic (PA) imaging are emerging therapeutic modalities for the diagnosis treatment of various types cancer or other diseases. In this study, second-generation photosensitizer Chlorin e6 was prepared on a pilot scale by using rapid, simple, green synthetic method as compared to conventional protocol. modified method, extraction/reaction time volume solvents were significantly reduced. The dark photodynamic cytotoxicity Ce6 measured against B16F10 melanoma cell...