A5017678759- TGF-β signaling in diseases
- Connective tissue disorders research
- Connective Tissue Growth Factor Research
- Congenital heart defects research
- Cerebrovascular and genetic disorders
- Proteoglycans and glycosaminoglycans research
University Hospital Cologne
2021-2023
University of Cologne
2021-2023
Bone morphogenetic proteins (BMP) are powerful regulators of cellular processes such as proliferation, differentiation, and apoptosis. However, the specific molecular requirements controlling bioavailability BMPs in extracellular matrix (ECM) not yet fully understood. Our previous work showed that targeted to ECM growth factor-prodomain (GF-PD) complexes (CPLXs) via interactions their PDs. We BMP-7 PD binding microfibril component fibrillin-1 renders CPLXs from an open, bioactive V-shape...
Dedifferentiated vascular smooth muscle cells (vSMCs) play an essential role in neointima formation, and we now aim to investigate the of bone morphogenetic protein (BMP) modulator BMPER (BMP endothelial cell precursor-derived regulator) formation. To assess expression arterial restenosis, used a mouse carotid ligation model with perivascular cuff placement. Overall after vessel injury was increased; however, tunica media decreased compared untreated control. Consistently, proliferative,...