A5068562627- Infectious Aortic and Vascular Conditions
- Aortic aneurysm repair treatments
- TGF-β signaling in diseases
- Cerebrovascular and genetic disorders
- Connective Tissue Growth Factor Research
- Aortic Disease and Treatment Approaches
University of Freiburg
2023-2024
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2024
Dedifferentiated vascular smooth muscle cells (vSMCs) play an essential role in neointima formation, and we now aim to investigate the of bone morphogenetic protein (BMP) modulator BMPER (BMP endothelial cell precursor-derived regulator) formation. To assess expression arterial restenosis, used a mouse carotid ligation model with perivascular cuff placement. Overall after vessel injury was increased; however, tunica media decreased compared untreated control. Consistently, proliferative,...
Vascular smooth muscle cells (VSMCs) play a key role in aortic aneurysm formation. Bone morphogenetic proteins (BMPs) have been implicated as important regulators of VSMC phenotype, and dysregulation the BMP pathway has shown to be associated with vascular diseases. The aim this study was investigate for first time effects BMP-4 on phenotype understand its development thoracic aneurysms (TAAs). Using angiotensin II (AngII) osmotic pump model mice, aortas from mice VSMC-specific deficiency...