A5010922821- Heart Failure Treatment and Management
- Antibiotics Pharmacokinetics and Efficacy
- Mechanical Circulatory Support Devices
- Pharmaceutical studies and practices
- Acute Kidney Injury Research
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Antimicrobial Resistance in Staphylococcus
- Cardiac Arrest and Resuscitation
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
- Anesthesia and Sedative Agents
- Renal function and acid-base balance
- Sepsis Diagnosis and Treatment
- Cardiovascular Syncope and Autonomic Disorders
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Epilepsy research and treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Atrial Fibrillation Management and Outcomes
- Pneumonia and Respiratory Infections
- Hemodynamic Monitoring and Therapy
Texas Children's Hospital
2014-2024
Baylor College of Medicine
2014-2024
Novartis (United States)
2024
University of Iowa Stead Family Children’s Hospital
2021
Penn State Milton S. Hershey Medical Center
2021
Phoenix Children's Hospital
2021
Boston Children's Hospital
2006-2019
Texas Medical Center
2019
The University of Texas at Austin
2017
Lurie Children's Hospital
2016
Differences in defining acute kidney injury (AKI) may impact incidence ascertainment. We assessed the effects of different AKI definition interpretation methods on epidemiology ascertainment.Two groups were studied at Texas Children's Hospital, Houston, Texas: 150 critically ill children (prospective) and 254 noncritically ill, hospitalized receiving aminoglycosides (retrospective). SCr was collected for 14 d prospective study 21 retrospective study. Children with known baseline serum...
Acute kidney injury (AKI) in hospitalized children results increased patient morbidity and mortality. Nephrotoxic-medication exposure is a common cause of AKI. Currently, no data exist to quantify the risks developing AKI for various nephrotoxic medications children. The primary aim current study assess potential association between risk noncritically ill with pre-existing renal insufficiency.We performed retrospective case-control pediatric patients aged 1 day 18 years. cases were who...
Background. Aminoglycosides (AG) cause acute kidney injury (AKI), but the incidence and severity distribution are unclear, particularly in non-critically ill children. We determined incidence, risk factors of AG-associated AKI assessed for associations with longer hospitalization higher costs. Methods. At Texas Children's Hospital, we conducted a retrospective cohort study children treated AG ≥ 5 days 2005, excluding admission primary renal diagnoses. was defined by paediatric Risk, Injury,...
Summary Background: Ketorolac is an injectable nonsteroidal anti‐inflammatory drug that often used as a transitional short‐term analgesic to treat moderate pain and decrease opioid use. There paucity of literature documenting the safety using ketorolac in neonates infants after cardiac surgery. Methods: A retrospective chart review was performed which identified all patients <6 months age who received Patients’ demographic, surgical, dosing data were collected. Student's t ‐test identify...
To determine the efficacy and safety of labetalol for hypertensive crisis in children ≤ 24 months age.Retrospective chart review. Statistical analysis utilized variance continuous data, chi-square tests nominal linear regression.A 737-bed pediatric teaching institution.Twenty-seven patients age were treated with 37 intravenous infusions labetalol, nicardipine, or nitroprusside urgency.None.The primary end point consisted time to 20% reduction systolic blood pressure. Primary points measured...
To assess the hemodynamic effects and safety of hydrocortisone in neonates with low cardiac output syndrome requiring high levels inotropic support fluid resuscitation after surgery.Retrospective chart review.Fifteen-bed pediatric cardiovascular intensive care unit.Twelve surgery to whom was administered according one two dosing regimens (100 mg/[m.day] for 2 days, 50 25 1 day or 100 day, days) were identified from Department Pharmacy database between September 2002 January 2004.None.The...
Objective Acute kidney injury (AKI) is a significant source of morbidity among critically ill pediatric patients, including those that have undergone cardiac surgery. Vancomycin may contribute to AKI in patients admitted intensive care unit. Design and Setting Patients the unit at Texas Children's Hospital received vancomycin over 4-year period were included case-control study. excluded if they underwent renal replacement therapy during therapy. Patient demographic disease state variables,...
Data are lacking to guide antimicrobial dosing for overweight children. The authors hypothesized that obese children would have increased vancomycin serum trough concentrations compared with nonobese children.A matched study design was employed compare retrospectively concentrations.Among 24 pairs, patients received 14.1 ± 1.5 mg per kilogram and 14.9 0.9 of (P = .03). There a trend toward higher in (6.9 4.30 μg/mL) versus (4.8 3.08 μg/mL; P .052). Mean half-life 2.9 0.29 hours volume...
The number of children receiving extracorporeal membrane oxygenation (ECMO) has increased substantially, and includes a growing population with complex underlying conditions who previously may not have been considered ECMO candidates. However, it remains unclear to what extent the disease impacts risk death in these patients, particularly related malignancy, bone marrow transplantation, congenital heart (CHD), or chromosomal abnormalities. A retrospective study was performed using Pediatric...
Sodium nitroprusside (SNP) is often used in postoperative pediatric cardiac surgical patients. Cyanide toxicity may occur with the use of SNP. There a paucity literature describing dosing parameters or physical signs and symptoms SNP.To determine incidence cyanide patients treated SNP identify that predict elevated concentrations.Medical records who received intensive care unit from January 2002 through December were identified evaluated for thiocyanate levels, dosing, toxicity. Patients...
We performed a retrospective case-cohort study of 50 obese pediatric patients aged 2 to 18 years who received scheduled gentamicin therapy, with serum peak and trough concentrations measured. Obese had significantly higher despite receiving lower mg/kg actual body weight doses gentamicin.
This study sought to evaluate the outcome and prevalence of viral endomyocardial infection after cardiac transplantation. Viral myocardial causes heart failure, but its role transplantation is unclear. We hypothesized that allograft reduces graft survival. Between June 1999 November 2004, 94 pediatric transplant patients were screened for presence genome in serial biopsies (EMBs) using polymerase chain reaction (PCR) assays. Graft loss, advanced coronary artery disease (TCAD), acute...