A5060555069- Cardiovascular Disease and Adiposity
- Hypothalamic control of reproductive hormones
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Erythrocyte Function and Pathophysiology
- Hemoglobinopathies and Related Disorders
- Lysosomal Storage Disorders Research
- Heavy Metal Exposure and Toxicity
- Parvovirus B19 Infection Studies
- Connective tissue disorders research
- Plant Reproductive Biology
- Mercury impact and mitigation studies
- Pancreatic function and diabetes
- Ovarian function and disorders
- Child Nutrition and Water Access
- Hydrogen's biological and therapeutic effects
- Pharmacological Effects and Toxicity Studies
- Iron Metabolism and Disorders
- Diabetes Treatment and Management
- Autoimmune and Inflammatory Disorders Research
- Diabetes Management and Research
- Inflammasome and immune disorders
- Genital Health and Disease
- Oil Spill Detection and Mitigation
- Vitamin K Research Studies
Kahramanmaraş Sütçü İmam University
2015-2024
Politecnico di Milano
2024
Maine Farmland Trust
2022
Stantec (Canada)
2022
Gaziantep University
2022
Pamukkale University
2022
Imam Mohammad ibn Saud Islamic University
2020
Owl Research Institute
2019
Cukurova University
2010-2015
Adana Numune Eğitim ve Araştırma Hastanesi
2012-2013
Gonadotropin-releasing hormone (GnRH) is the central regulator of gonadotropins, which stimulate gonadal function. Hypothalamic neurons that produce kisspeptin and neurokinin B GnRH release. Inactivating mutations in genes encoding human receptor (KISS1R, formerly called GPR54), (TAC3), (TACR3) result pubertal failure. However, loss-of-function have not been described, contradictory findings reported Kiss1-knockout mice. We describe an inactivating mutation KISS1 a large consanguineous...
Machine Learning (ML) has proven to be a promising solution provide novel scalable and efficient fault management solutions in modern 5G-and-beyond communication networks. In the context of microwave networks, ML-based have received significant attention. However, current can only applied monolithic scenarios which single entity (e.g., an operator) manages entire network. As network architectures move towards disaggregated platforms multiple operators vendors collaborate achieve...
Iron deficiency anemia (IDA) remains the most prevalent nutritional in infants worldwide. The purpose of this study was to determine efficacy daily and weekly iron supplementation for 3 months improve status 4-month-old, exclusively breast-fed healthy infants. Infants 4 age were eligible open, randomized controlled trial if their mothers intended continue exclusive breast-feeding until 6 age. or with (ID) IDA on admission excluded. (n = 79) randomly assigned three groups, first group...
Normosmic idiopathic hypogonadotropic hypogonadism (nIHH) is characterized by failure of initiation or maintenance puberty due to insufficient gonadotropin release, which not associated with anosmia/hyposmia. The objective this study was determine the distribution causative mutations in a hereditary form nIHH.In prospective collaborative study, 22 families more than one affected individual (i.e. multiplex families) nIHH were recruited and screened for genes known suspected be strong...
The key event initiating the onset of puberty is activation gonadotropin-releasing hormone neurons in hypothalamus. There substantial evidence from human and animal studies that neuropeptide kisspeptin its receptor (KISS1R, formerly known as GPR54) play a fundamental regulatory role initiation reproductive maturation. Gonadotropin-releasing release stimulated by hypothalamic producing neurokinin B. Inactivating mutations genes encoding KISS1R or B result pubertal failure. Moreover,...
Summary Objective The spectrum of genetic alterations in cases hypogonadotropic hypogonadism continue to expand. However, KISS 1R mutations remain rare. aim this study was understand the molecular basis normosmic idiopathic hypogonadism. Methods Clinical characteristics, hormonal studies and analyses seven with ( nIHH ) from three unrelated consanguineous families are presented. Results One male presented absence pubertal onset required surgery for severe penoscrotal hypospadias...
Abstract Background: The aim of this study was to compare the chromium levels plasma (PCL), erythrocyte (ECL) and urine (UCL) in type 1 diabetics healthy subjects review relation between metabolic parameters. Methods: We evaluated 165 who were: newly diagnosed (group [ n = 29]); previously 2 18]); non‐diabetic control were admitted treated for any reason hospital 3 21]); two other groups from schools that have different socioeconomic 4 48] group 5 49]). Results: PCL (7.21 ± 4.78 10.94 3.04...
The aim of this study was to elucidate the role adiponectin, leptin, TNF-α and IL-6 on early detection microvascular complications type I diabetes.A total 88 children were included in study. There 60 diabetic patients 28 healthy control children.The gender, age, weight, height, BMI puberty status characteristics similar patient groups (p>0.05). serum levels between (p>0.05) only difference adiponectin level which higher group (p:0.042). We also found no association diabetes duration Leptin...
Abstract Introduction: Obesity is usually related to insulin resistance and glucose metabolism disorders. The relationship between epicardial adipose tissue atrial electromechanical delay has been described in previous studies. Aim: This study aims demonstrate the effects of metformin on patients using for resistance. Materials methods: A total 30 were included study. Pre-treatment post-treatment evaluated. Results: There was a statistically significant decrease thickness after 3 months...
WISP3 is a member of the CCN (for CTGF, CYR61, and NOV) gene family, which encodes cysteine-rich secreted proteins with roles in cell growth differentiation. Mutations are associated autosomal recessive skeletal disorder, also known as progressive pseudorheumatoid arthropathy childhood (PPAC). We diagnosed three siblings from non-consanguineous family PPAC. The patients were asymptomatic early childhood. Signs symptoms disease that include joint stiffness, swelling finger joints, osteopenia,...
Ecthyma gangrenosum is an infective lesion of the skin and mucosal membranes. It most commonly caused by Pseudomonas aeruginosa, important risk factors are malignancy neutropenia. However, it has rarely been reported in children who were previously healthy. Persistent hyperplastic primary vitreous described as persistence fetal hyaloid vascular system. Acute otitis media with facial paralysis infrequent association.We report case a 5-month-old boy hospitalized because fever, otorrhea...
Background and Objective: Childhood obesity is one of the worldwide health problems with an increasing prevalence accompanied by severe morbidity mortality. It a serious predisposing risk factor especially for development cardiovascular diseases arrhythmias. Electromechanical delay (EMD) known to be predictor atrial fibrillation (AF). Our study aims investigate whether EMD, which AF, prolongs in obese children or not.The included 59 patients aged between 8-18 years 38 healthy as control...
The prevalence of childhood obesity is increasing and leads to co-morbidities such as hypertension. However, it still not clear why some obese individuals are hypertensive others not. Nesfatin-1 a recently discovered anorexigenic peptide which also has effects on blood pressure (BP). Our aim was evaluate the relationship between obesity-related hypertension Nesfatin-1.This cross-sectional study comprised 87 children. patients were divided into two groups; (n=30) normotensive (n=57) obese....
Growth Hormone (GH) is a 22 kDa protein that has effects on growth and glucose fat metabolisms. These are initiated by binding of hormone to receptors (GHR) expressed in target cells. Mutations or deletions the receptor cause an autosomal disorder called Laron-type dwarfism (LS) characterized high circulating levels serum GH low insulin like factor-1 (IGF-1). We analyzed GHR gene for genetic defect seven patients identified as Laron type dwarfism. two missense mutations (S40L W104R), four...
Aim: This study was planned to evaluate bone health in patients with hereditary spherocytosis.Materials and methods: In this prospective study, a total of 30 spherocytosis which followed the Pediatric Hematology Oncology Department KSU Medical Faculty for control group were included. Patient chosen equal age sex. Hemogram biochemical tests (serum calcium, phosphorus, alkaline phosphatase, parathormone, vitamin D) osteocalcin studied from patient groups. Also DXA examination performed...
Amaç: Kene tutması ölümcül hastalıkların bulaşabilmesi nedeniyle son 10 yıldır giderek önem kazanmak-