A5008961771- Advanced Fluorescence Microscopy Techniques
- Plasma Applications and Diagnostics
- Metal and Thin Film Mechanics
- Electrohydrodynamics and Fluid Dynamics
- Photoreceptor and optogenetics research
- Quantum Information and Cryptography
- Ubiquitin and proteasome pathways
- Ion channel regulation and function
- Cellular transport and secretion
- Supply Chain and Inventory Management
- Power Transformer Diagnostics and Insulation
- Sustainable Supply Chain Management
- Quantum Mechanics and Applications
- CRISPR and Genetic Engineering
- RNA regulation and disease
- Neurological diseases and metabolism
- Hearing, Cochlea, Tinnitus, Genetics
- Extracellular vesicles in disease
- Traumatic Brain Injury and Neurovascular Disturbances
- Cold Atom Physics and Bose-Einstein Condensates
- Sustainability and Ecological Systems Analysis
- Glycosylation and Glycoproteins Research
- Cellular Mechanics and Interactions
- Diabetes Treatment and Management
- Oral and gingival health research
Sichuan University
2009-2025
State Key Laboratory of Oral Diseases
2023-2025
Chengdu University
2024
Duke-NUS Medical School
2024
Chongqing University
2004-2023
National University of Singapore
2016-2022
Jiangxi University of Finance and Economics
2009-2017
State Key Laboratory of Biotherapy
2009
Chongqing Medical University
2004-2009
Nanchang University
2009
Free fatty acid receptors 2 and 3 (FFAR2/FFA2/GPR43 FFAR3/FFA3/GPR41) are mammalian for gut microbiota-derived short-chain acids (SCFAs). These promising drug targets obesity, colitis, colon cancer, asthma, arthritis. Here, we demonstrate that FFAR2 FFAR3 interact to form a heteromer in primary human monocytes macrophages via proximity ligation assay, during heterologous expression HEK293 cells bimolecular fluorescence complementation resonance energy transfer. The FFAR2-FFAR3 displayed...
Injectable antibacterial and osteoinductive hydrogels have received considerable attention for promoting bone regeneration owing to their versatile functionalities. However, a current hydrogel with antibacterial, osteoinductive, antioxidant properties by facile method periodontitis treatment is still missing. To overcome this issue, we designed an injectable system (GPM) composed of gelatin, Ti3C2Tx MXene nanosheets, poly-l-lysine using simple enzymatic cross-linking technique....
Adult mesenchymal stem cells (MSCs) play a crucial role in maintaining bone health and promoting regeneration. In our previous research, we identified Gli1+ MSCs as key contributors to the formation of most trabecular adulthood essential for healing bicortical fractures. However, mechanisms behind maintenance differentiation are still not fully understood. O-linked N-acetylglucosamine modification (O-GlcNAcylation), mediated by O-GlcNAc glycosyltransferase (OGT), is involved various...
Calcium (Ca²⁺) release from intracellular stores, Ca²⁺ entry across the plasma membrane, and their coordination via store-operated (SOCE) are critical for receptor-activated oscillations. However, precise mechanism of oscillations whether control loop resides at membrane or intracellularly remain unresolved. By examining dynamics stromal interaction molecule 1 (STIM1)-an endoplasmic reticulum (ER)-localized sensor that activates Orai1 channel on SOCE-and in mast cells, we found a significant...
Interest in the use of recombinant retroviral vectors for clinical gene therapy has been tempered by evidence vector-mediated genotoxicity involving activation cellular oncogenes flanking sites vector integration. We report here that rate gammaretroviral can be significantly reduced addition cHS4 chromatin insulator, based on two complementary approaches assessing genotoxicity. One approach involves direct, genomewide assessment dysregulation using panels transduced cell clones and genomic...
Cranial bone defects remain a major clinical challenge, increasing patients' life burdens. Tricarboxylic acid (TCA) cycle metabolites play crucial roles in facilitating tissue regeneration. However, the development of TCA metabolite-modified biomimetic grafts for skull regeneration still needs to be improved. The mechanism underlying release from biomaterials regulating immune responses and mesenchymal stem cell (MSC) fate (migration differentiation) remains unknown. Herein, this work...
The coordination between actin and microtubule network is crucial, yet this remains a challenging problem to dissect our understanding of the underlying mechanisms limited. In study, we used travelling waves in cell cortex characterize collective dynamics cytoskeletal networks. Our findings show that Cdc42 F-BAR-dependent mast cells are mainly driven by formin-mediated polymerization, with microtubule-binding formin FH2 domain-containing protein 1 (FHDC1) as an early regulator. Knocking down...
In the last decade, overexpression of hepatoma upregulated protein (HURP) has been reported in hepatocellular carcinoma, adrenocortical tumors and urogenital carcinoma. However, role HURP breast cancer remains unknown. present study, a comprehensive analysis was performed to examine expression level 43 tumor samples paired adjacent normal tissues. The correlation between clinicopathological characteristics evaluated. investigated by quantitative polymerase chain reaction, western blot cell...
Increased intracranial pressure after traumatic brain injury (TBI) is an urgent problem in clinical practice. A pliable hydrogel preferred for cranioplasty applications TBI since it can protect tissue and promote bone healing. Nevertheless, biohydrogels cranial regeneration still face challenges of poor mechanical properties, large swelling ratios, low osteogenesis activity. Herein, inspired by Hofmeister effects, biopolymer hydrogels composed protein polysaccharides were treated with a...
A system dynamics model of a traditional /closed loop supply chain is investigated in the manufacturer echelon under APIOBPCS (Automatic Pipeline Inventory and Order Based Production Control System). The effect remanufacture return ratio on oscillation amplification were studied. Our results clearly showed that ordering policy designed for production with unidirectional flow materials (i.e., up stream to down only), when applied such an integrated involving manufacturing remanufacturing can...
Pre-breakdown processes in water are usually accompanied by the developments of bubble and streamer. Therefore, dynamic behaviors streamer their transition process essential to understand mechanism underwater discharge. In this work, pre-breakdown (60 μS/cm) under ultra-long pulses (>100 ms) investigated, two fundamental but unclear issues clarified: What is intrinsic difference between streamer, how does a transit into streamer? The research results manifest that follow pattern cycle...
Liquid phase disturbances are often observed in pre-breakdown processes; however, their dynamic behaviors rarely studied. In this paper, time evolution characteristics of liquid disturbance under ultra-long pulses (>100 ms) were investigated. The results showed that the steady expansion follows pattern constant heating power, volume growth rate, and temperature (about 52 °C unvaried with applied voltage). shrinkage voltage leads to breakdown transition from a full disturbed mode...
The raw materials order rate exhibits dynamic behaviors such as additional system oscillation and demand amplification caused by the increase in desired stock triggered surge production starts. A dynamics model of a supply chain consisting two stages is investigated. impact reverse logistics for direct reuse productions on studied this paper. Our results clearly showed that management do to help restraining behavior chains. Furthermore, simulation illustrate weakening degree will be greater...
Abstract Mitochondrial plasticity, coordinated by fission and fusion, is crucial to ensure cellular functions. mediated the GTPase Drp1 at constriction site, which proposed be driven actin-myosin contractile force. However, mechanism that propels remains unclear, potential involvement of additional mechanisms in this process an open question. Here, using structured illumination microscopy electron microscopy, we show type-III intermediate filament glial fibrillary acidic protein (GFAP)...
Summary Impaired proteostasis can induce protein aggregation which is toxic to neuronal cells, contributing neurodegeneration and other signs of aging. In this study, we delineate an early-onset progressive neuropathy evoking Giant Axonal Neuropathy 1. The causative gene IVNS1ABP encodes a E3-ubiquitin ligase adaptor close gigaxonin paralogue. Patient-derived fibroblasts, iPSCs, neural progenitors exhibited hallmarks accumulation lysosomal dysfunction. Ubiquitome analysis revealed...
Developing new high-performance packaging technologies adapting for the third-generation semiconductors is urgent need to related industry applications nowadays. In this work, we reported a novel method rapid sintering and nondestructive testing of Nano-metal chip bonding layer by pulsed current discharge, which can realize short time (ms level), low temperature (<200 ℃) high strength (>50 MPa). The physical mechanism behind transient process was revealed based on speed observation,...
Abstract The endoplasmic reticulum and plasma membrane (ER-PM) contact site dynamics plays a central role for store-operated calcium entry (SOCE). ER localized sensor STIM1 translocates to the sites, interacts with Orai mediates influx from extracellular environment. Different species of phosphoinositides (PIPs) have been reported be involved in as well translocation. However, most studies were based on loss-of-function experiments or conditions that generate massive store depletion....
Prebreakdown time delay is one of the key breakdown characteristics which can reflect insulation and discharge performances dielectric liquids. In this article, investigation voltage-varying prebreakdown delays corresponding voltage polarity effects for underwater millisecond discharges have been carried out. The results indicated that effect total determined by formation at low applied voltage; meanwhile, propagation high voltage. It was further found liquid phase disturbance induced Joule...