This report evaluated the short and midterm results of safety effectiveness treatment technique with hybrid non-hybrid Y-configured, dual stent-assisted coil embolization wide-neck intracranial aneurysms, reviewed literature concerning this technique. Nine patients, eight unruptured one ruptured aneurysms were included in study. Of embolized a (with two different stents) identical technique, three located anterior communicating artery, at tip distal site basilar middle cerebral artery. All...

Peripheral nerve injury (PNI) is a major health problem that results in loss of motor and sensory functions. In treatment PNI, various methods such as anastomosis, grafts, nonneural tissue conduits are applied. the present study, it was aimed to investigate effects Theranekron Alpha-lipoic acid (ALA) combined on healing experimental PNI by using histomorphometric, electron microscopic, immunohistochemical molecular biological methods. Sixty-two Wistar rats were divided into six groups;...

Objectives: The aim of the study was to determine relationships between microRNA-20a and microRNA-125b expression apoptosis inflammation in a rat model spinal cord injury (SCI) using microscopy, immunohistochemistry, molecular biology.Methods: Sixty-one rats were divided into three groups: control group that not subjected any operation; sham-operated group; an experimental compression. further subdivided two subgroups: group, which did receive drug treatment; methylprednisolone treatment...

Functional disorders of the glymphatic system and Aquaporin-4 (AQP-4) channels take part in pathophysiology neurodegenerative disease. The aim this study was to describe distribution AQP-4 prefrontal cortex hippocampus a mouse model NMDA receptor blocking agent-induced schizophrenia-like behavior model. antagonist MK-801 used produce experimental schizophrenia injections were administered for eleven days Balb/c mice intraperitoneally. Beginning from sixth day injection, spatial learning...

Glioblastoma (GBM, WHO grade IV) accounts for 50% of all the intracranial tumors and 70% primary malignant brain tumors.Although GBM often occurs in late adulthood (70% at a mean age 53 years), up to 8.8% occur during childhood.Absence specific symptoms is predominant reason which are detected advanced stages, leading poor prognosis with survival 1 year (18). █ INTRODuCTIONA ny tumor that arises from glial or supportive tissue spinal cord called "glioma".One types glioma...

Abstract Chronic subdural hematoma is a frequent type of hemorrhage, which terminates with mortality if not diagnosed and treated early. The aim this clinical study to evaluate the patients unilateral bilateral recurrent chronic hematoma. group consisted 13 cases hematomas who underwent aggressive wide craniotomy, duraectomy, inner outer membranectomy, dural border coagulation, incision through cortical vein trace hang up edge, between 2009 - 2016. All our were by preoperative Magnetic...

Volatile agents combined with opioids or α2 agonists may reduce inhalation concentration provide optimal hemodynamic stability. We compared the stability brain relaxation, and recovery characteristics of sevoflurane anesthesia supplemented an infusion dexmedetomidine remifentanil in patients undergoing supratentorial craniotomy. enrolled 80 adult a prospective randomized 2 group study. ASA I-III physical status who were intracranial surgery for either vascular space-occupying lesions,...

A natural agent that maintains mesenchymal stem cell (MSCs) viability, promotes osteogenic differentiation while modulating the immunological response could achieve success in regeneration during healing and may also prevent bone resorption improve regeneration. We aimed to demonstrate a Thymbra spicata var. intricata extract induce proliferation, differentiation, modulate immune responses of cells (MSCs). Using xCELLigence, real-time monitoring system, we obtained growth curve MSCs. dose 10...

It is a big issue that reduced bone density and large fractıres in dentistry orthopedics. Side effects caused by synthetic drugs lead to medical ethical problems. Thus, plants medicinal plant research take attention. Aim of this preliminary vitro study investigate the effect Ocimum basilicum extract on dental pulp (DP) marrow (BM) derived mesenchymal stem cell (MSC) proliferation, osteogenic differentiation immunological response TNF-α. Human tissue was obtained from patients (15-20 years...

Zinc borate is a white crystalline powder substance with variable composition (34% B 2 O 3 , 45% ZnO and 20% H O). It used as fungus mildew inhibitor, to fire proof textiles, for other uses. Although there are limited studies about the biologic properties of this compound. The present study was aimed investigate antioxidant antimutagenic activity zinc also figure out its cytotoxic effect. Antioxidant determined β- carotene linoleic acid DPPH radical scavenging assays. mutagenicity AMES/...

Background and objective There is currently no consensus on pain management after craniotomy in neurosurgical centers the world. We have investigated either addition of diclofenac sodium or paracetamol to tramadol for analgesia craniotomy. Methods Fifty patients were allocated randomly receive an intravenous with (DT) plus (PT), a double-blind, randomized study. Then, all received bolus doses (1.5 mg/kg) every 6 hours during first 24 hours. Discomfort, sedation, scores, side effects recorded...

Spinal cord injury (SCI) is an important health problem, and there no universal treatment protocol for it today. Following SCI pro-inflammatory mediators such as tumor necrosis factor- alpha (TNF-α) interleukin-6 (IL-6) increase at the lesion site play roles in secondary tissue damage. Methylprednisolone (MP) a glucocorticoid, minocycline tetracycline-derived antibiotic both with neuroprotective effects on central nervous system trauma. However, are limited studies their SCI. In this study,...

In the current study we aim to investigate effects of vitamin C and profol on red blood cell deformability in diabetic rats.Twenty- eight Wistar Albino rats were included after streptozocin (60 mg/kg) treatment for 4 weeks observation diabetes presence. Twenty-eight allocated groups. group DP (n = 7) 150 mg.kg-1 propofol was injected intraperitoneally. DP-vit 100 mg/kg (Ascorbic acid, Redoxon® 1000 mg/5 mL - Roche) applied one hour before administrating propofol, while control 7), received...

Our aim was to investigate whether neutralization of rat interleukin 6 (IL-6) bioactivity attenuates inducible nitric oxide synthase (iNOS) up-regulation and ameliorates cerebral ischemic damage in a model focal central nervous system (CNS) ischemia.Seventy rats were randomly allocated groups: Group I (n=10) consisted normal controls; II (n=20) underwent surgical exposure the middle artery but no cauterization; remaining 40 subjected occlusion. Immediately after occlusion, each these...

Lornoxicam and iv paracetamol are commonly preferred to be used for postoperative analgesia. Although Aspirin is a well known non-steroid anti-inflammatory drug that decreases the erythrocyte deformability, there no study comparing lornoxicam regarding their effects on deformability recorded in literature. The aim of this was compare IV blood perfusion rats.Twenty male Wistar Albino rats were randomly divided into three groups as group (Group L), P), control C). Intraperitoneal...

Currently, these are known to be lobulated raspberry-like lesions with abnormal hyalinized capillaries surrounded by hemosiderin deposits and a well-circumscribed gliotic margin (1,14,17).CM can solitary one or two lesions, sporadic in clustered nature, multifocal familial.Approximately 40% patients asymptomatic.Symptoms arise due irritation, mass effect, hemorrhage 70%, 20%, 10% patients, respectively.█ INTRODUCTION C avernous malformation (CM) was first described 1846 as developmental...

Inflammasome NLR family pyrin domain-containing 3 (NLRP3) is associated with neurological disorders. Neuroinflammation can be suppressed by inhibiting NLRP3 inflammasome activation, decreasing neurodegenerative disorder progression. We devised a therapeutic technique that reduce neuroinflammation induced microglial avoiding neurodegeneration. aimed to investigate the mechanisms underlying pharmacological effects of galantamine and wedelolactone evaluating response nuclear factor kappa B...

Fresh autogenous bone graft is the most preferred osteoplastic material, whether purpose cosmetic, psychological, or for protection of brain. These grafts are not rejected and do react immunologically. The aim this study was to evaluate efficacy fat rolled with dust derived from bur hole in closing small cranial defects. Additionally, authors examined morphological biochemical effects Na selenite amiloride on calvarial calcification.The group consisted 20 domestic pigs. animals were randomly...

Administration of morphine with intravenous patient-controlled analgesia (PCA) is a routine technique in postoperative pain relief on laminectomy. In this study, we aimed to evaulate the effect preemptive paravertebral somatic block levobupivacaine consumption. After approval Medical Faculty Ethics Commitee and patient consent, aged 20-70 years, American Society Anesthesiologist physical status I–II, 100 patients who were undergoing laminectomy, included. Patients randomly divided into 2...

Objectives Cerebral vasospasm after subarachnoid hemorrhage (SAH) is a reversible arterial narrowing occurring as result of the mechanical and physiologic effects blood products. Multiple factors are effective in development narrowing; they provide long-term contraction, inhibition vasodilatation, depression metabolic, immunoreactive, inflammatory processes. We assessed Na selenite, which activates calpain II promotes intracellular Ca2+ influx, by increasing oxygen radical synthesis SAH....

calcium-dependent cystein, protease activators (PA), heparinase, and proteolytic enzymes.These stimuli that are formed mostly of cytokines GF activate their own tumour cells by stimulating microglia, endothelial cells, coagulation factors thrombocytes, several stimulants affect the hemostatic system, growth, invasion immunological system expressed from these tissues (5,6,9,22).In invasive, proliferative, destructive, infiltrative, malignant tumours, such as glioblastoma multiforme (GBM),...