A5068247678- Protease and Inhibitor Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Acute Ischemic Stroke Management
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Antimicrobial Peptides and Activities
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- Neonatal and fetal brain pathology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood properties and coagulation
- Neurological Disease Mechanisms and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Streptococcal Infections and Treatments
- Nitric Oxide and Endothelin Effects
- Platelet Disorders and Treatments
- Neurological Disorders and Treatments
- Biochemical and Structural Characterization
- Cerebral Venous Sinus Thrombosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Enzyme Production and Characterization
- Atherosclerosis and Cardiovascular Diseases
- Pregnancy and preeclampsia studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
University of Pennsylvania
2011-2024
Hadassah Medical Center
2003-2024
Hebrew University of Jerusalem
1985-2023
Hadassah Academic College
1992-2022
Herzog Hospital
1995-2020
Hadassah
1993-2003
Thomas Jefferson University
1997-2002
Rappaport Family Institute for Research in the Medical Sciences
2002
University of Delaware
1997-2001
Jefferson College
2000
Journal Article Hyperinsulinemic hypoglycemia of infancy (nesidioblastosis) in clinical remission: high incidence diabetes mellitus and persistent beta-cell dysfunction at long-term follow-up Get access G Leibowitz, Leibowitz 1Department Endocrinology, Hebrew University Hadassah Medical Center, Jerusalem, Israel. Search for other works by this author on: Oxford Academic Google Scholar B Glaser, Glaser A Higazi, Higazi M Salameh, Salameh E Cerasi, Cerasi H Landau The Clinical Endocrinology &...
Accumulation of low-density lipoprotein (LDL)-derived cholesterol by macrophages in vessel walls is a pathogenomic feature atherosclerotic lesions. Platelets contribute to lipid uptake through mechanisms that are only partially understood. We have previously shown platelet factor 4 (PF4) inhibits the binding and degradation LDL its receptor, process could promote formation oxidized (ox-LDL). now characterized effect PF4 on ox-LDL vascular cells accumulation esters. bound directly also...
Angiogenesis, the growth of new blood vessels, is a complex biological process that orchestrated by several factors and components extracellular matrix, including fibronectin (FN) its receptor integrin alpha5beta1. Angiogenesis critical part inflammation wound repair, but mechanism which vascular proliferation migration regulated inflammatory cells not completely understood. We have previously shown human neutrophil peptides (HNPs), also known as alpha-defensins, are secreted in high...
Single-chain urokinase (scuPA), the unique form of secreted by cells, is converted to an active two-chain molecule through cleavage a single peptide bond plasmin and other specific proteinases. Although scuPA may express limited enzymatic activity, its contribution plasminogen activation on cell surfaces remains uncertain. Further, although it well known that binds extracellular urokinase-type activator receptor, effect this interaction activity has not been described. In present paper we...
The involvement of neutrophil activation in the sentinel, potentially reversible, events pathogenesis acute lung injury (ALI) is only partially understood. alpha-Defensins are most abundant proteins secreted by activated human neutrophils, but their contribution to ALI mouse models hindered absence from murine neutrophils and inability study effects isolation other species.To role alpha-defensins a clinically relevant setting using mice transgenic for polymorphonuclear leukocyte expression...
Defensins are naturally occurring antimicrobial peptides that may participate in host defense against microorganisms. We previously reported the amino acid sequence of leukocyte defensins resembles lysine-binding site kringles plasminogen and defensin inhibits fibrinolysis mediated by tissue-type activator (tPA) plasminogen. In present paper we analyze mechanisms this inhibition. Defensin binds specifically to cultured human umbilical vein endothelial cells (HUVEC) (half-maximal binding = 3...
Adherence of Mycoplasma fermentans to HeLa cells followed saturation kinetics, required a divalent cation, and was enhanced by preincubation the organism at 37 degrees C for 1 h in low-osmolarity solution. Proteolytic digestion, choline phosphate, or anti-choline phosphate antibodies partially inhibited adherence, supporting notion that M. utilizes least two surface components adhesion, protease-sensitive protein phosphocholine-containing glycolipid. Plasminogen binding greatly increased...
An inhibitor of tissue-type plasminogen activator (tPA)-mediated and plasminogen-dependent fibrinolysis was isolated from human neutrophils. On a G-50 gel filtration column, the antifibrinolytic activity present in neutrophil homogenates comigrated with proteins <13 kDa. The inhibitory fraction had only slight effect on urokinase plasminogen- or plasmin-mediated no urokinase- cleavage H-D-valyl-L-leucyl-L-lysine-p-nitroanilide (S-2251). neutrophil-derived inhibited tPA S-2251 but not...
In patients with acute ischemic stroke, diabetes and hyperglycemia are associated increased infarct size, more profound neurologic deficits higher mortality. Notwithstanding extensive clinical experimental data, treatment of stroke-associated insulin is controversial. addition to hyperglycemia, even early prediabetic resistance levels amino acids, including the neurotoxic glutamate, in circulation. The pleiotropic metabolic effects include a reduction concentration acids this article, we...