A5080406533- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Virus-based gene therapy research
- Phytochemicals and Antioxidant Activities
- Chromosomal and Genetic Variations
- Silk-based biomaterials and applications
- Pluripotent Stem Cells Research
- Pomegranate: compositions and health benefits
- Logic, programming, and type systems
- Medicinal plant effects and applications
- Antioxidant Activity and Oxidative Stress
- Hops Chemistry and Applications
Roslin Institute
2015-2023
University of Edinburgh
2015-2023
Australian Centre for Disease Preparedness
2019
CSIRO Health and Biosecurity
2019
Norwich Research Park
2013
Quadram Institute
2013
United States Department of Defense
1999
Precise self-renewal of the germ cell lineage is fundamental to fertility and reproductive success. The early precursors for lineage, primordial cells (PGCs), survive proliferate in several embryonic locations during their migration gonad. By elucidating active signaling pathways migratory PGCs vivo, we were able create culture conditions that recapitulate this environment. In defined medium without feeder cells, growth factors FGF2, insulin, Activin A, through cognate-signaling pathways,...
Poultry is the most abundant livestock species with over 60 billion chickens raised globally per year. The majority of chicken are produced from commercial flocks, however many indigenous breeds play an important role in rural economies as they well adapted to local environmental and scavenging conditions. ability make precise genetic changes will permit validation variants responsible for climate adaptation disease resilience, transfer beneficial alleles between breeds. Here, we generate a...
Significance In the fields of conservation biology and sustainable agriculture, ability to cryopreserve revive animal species is paramount efforts preserve genetic diversity. An innovative approach use sterile surrogate host animals for transplantation reproductive germ cells from rare/endangered animals. This technology has previously been utilized in mammals but particular importance with lipid-filled zygotes/embryos, such as fish birds, which render cryopreservation techniques...
There is increasing evidence that consumption of plant bioactives such as polyphenols and glucosinolates reduces cardiovascular disease risk improves endothelial function. In the Black Sea area, a number plants are consumed alone ingredients in traditional foods, dill, nettle, kale, Sideritis persimmon were identified bioactive-rich food plants. The present study investigated effects extracts on cellular markers function (eNOS activation expression ET-1 secretion).Treatment human umbilical...
Primordial germ cells (PGCs) are germline-restricted embryonic that form the functional gametes of adult animal. The use avian PGCs in biobanking and producing genetically modified birds has driven research on vitro propagation manipulation these cells. In species, hypothesized to be sexually undetermined at an early stage undergo differentiation into oocyte or spermatogonial fate dictated by extrinsic factors present gonad. However, chicken male female require different culture conditions,...
Summary Poultry is the most abundant livestock species with over 60 billion chickens raised globally per year. While chicken are produced from highly selected commercial flocks many indigenous breeds, which have low productivity and not been selected, play an important role in rural economies across world as they well adapted to local environmental scavenging conditions. The ability rapidly transfer genetic changes between breeds of will permit beneficial alleles poultry allow validation...