A5015702677- COVID-19 Clinical Research Studies
- Cell death mechanisms and regulation
- SARS-CoV-2 and COVID-19 Research
- Protein Kinase Regulation and GTPase Signaling
- PI3K/AKT/mTOR signaling in cancer
- Immunotherapy and Immune Responses
- Hepatitis C virus research
- Macrophage Migration Inhibitory Factor
- Hepatitis B Virus Studies
- Dietary Effects on Health
- Hepatitis Viruses Studies and Epidemiology
- Amyotrophic Lateral Sclerosis Research
- Gut microbiota and health
- Animal Virus Infections Studies
- Clostridium difficile and Clostridium perfringens research
- Cell Adhesion Molecules Research
- Biochemical Acid Research Studies
Karolinska Institutet
2021-2024
Karolinska University Hospital
2022-2024
Xinxiang Medical University
2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific neutralizing antibodies (NAbs) lack cross-reactivity between SARS-CoV species and variants fail to mediate long-term protection against infection. The maintained severe disease death by vaccination suggests a role for cross-reactive T cells. We generated vaccines containing sequences from the spike or receptor binding domain, membrane and/or nucleoprotein that induced only cells, cells NAbs, understand their individual...
High expression of phosphatidylinositol 4-kinase III alpha (PI4KIIIα) correlates with poor survival rates in patients hepatocellular carcinoma. In addition, hepatitis C virus (HCV) infections activate PI4KIIIα and contribute to carcinoma progression. We aimed at mechanistically understanding the impact on progression liver cancer potential contribution HCV this process.
Aims: In addition to reducing the respiratory function, crystalline silica (SiO2) disturbs immune response by affecting cells during progression of silicosis. Regulatory T cell (Treg) differentiation may play a key role in abnormal polarization helper (Th)1 and Th2 development silicosis-induced fibrosis. Alpha-lipoic acid (ALA) has immunomodulatory effects promoting Tregs differentiation. Thus, ALA have therapeutic potential for treating autoimmune disorders patients with However, little is...
Ischemic stroke is one of the major issues in public health. The commensal gut microbiota has been discovered to influence brain activity through a bidirectional communication pathway. interplay and does not only occur physiological status but also distinct pathological conditions. Here we summarized recent advances on interactions between ischemic actions. We emphasized impacts from main concerns during post-stroke management, including immune responses, body temperature, blood glucose,...
ABSTRACT Background and Aims High expression of phosphatidylinositol 4-kinase III alpha (PI4KIIIα) correlates with poor survival rates in patients hepatocellular carcinoma (HCC). In addition, Hepatitis C virus (HCV) infections activate PI4KIIIα contribute to HCC progression. We aimed at mechanistically understanding the impact on progression liver cancer potential contribution HCV this process. Methods Several hepatic cell culture mouse models were used study functional importance...