A5065254316- Parathyroid Disorders and Treatments
- Bone health and treatments
- Bone Metabolism and Diseases
- Genetic Syndromes and Imprinting
- Sports injuries and prevention
- Orthopedic Surgery and Rehabilitation
- Genetic Mapping and Diversity in Plants and Animals
- Shoulder Injury and Treatment
- Genetic and phenotypic traits in livestock
- Bone health and osteoporosis research
- Bone Tissue Engineering Materials
- Medical Imaging and Pathology Studies
- Animal Nutrition and Physiology
- Periodontal Regeneration and Treatments
- Fibroblast Growth Factor Research
- Growth Hormone and Insulin-like Growth Factors
- Bone and Dental Protein Studies
- Magnesium in Health and Disease
- Shoulder and Clavicle Injuries
- Hip and Femur Fractures
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Biomedical Research and Pathophysiology
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Neonatal Respiratory Health Research
Uppsala University Hospital
2008-2024
Uppsala University
2003-2023
Aalborg University
2017
University of Borås
2012
Sahlgrenska University Hospital
2012
Harvard University
2001-2005
Massachusetts General Hospital
2001-2005
Mutations in fibroblast growth factor 23 (FGF-23) cause autosomal dominant hypophosphatemic rickets. Clinical and laboratory findings this disorder are similar to those oncogenic osteomalacia, which tumors abundantly express FGF-23 messenger RNA, X-linked hypophosphatemia, is caused by inactivating mutations a phosphate-regulating endopeptidase called PHEX. Recombinant induces phosphaturia hypophosphatemia vivo, suggesting that it has role phosphate regulation. To determine whether...
Mutations in the fibroblast growth factor 23 gene, FGF23, cause autosomal dominant hypophosphatemic rickets (ADHR). The gene product, FGF-23, is produced by tumors from patients with oncogenic osteomalacia (OOM), circulates at increased levels most X-linked hypophosphatemia (XLH) and phosphaturic when injected into rats or mice, suggesting involvement regulation of phosphate (Pi) homeostasis. To better define precise role FGF-23 maintaining Pi balance bone mineralization, we generated...
Fibroblast growth factor-23 (FGF23) is a circulating factor that decreases serum levels of inorganic phosphate (Pi) as well 1,25-dihydroxyvitamin D 3 . Recent studies also suggest correlation between FGF23 and parathyroid hormone (PTH) in patients with chronic kidney disease. It is, however, unknown whether directly modulates PTH expression, or the secondary to abnormalities Pi vitamin metabolism. The objective current study was therefore elucidate possible direct effects on bovine cells...
The gene mutated in autosomal dominant hypophosphatemic rickets (ADHR), a phosphate wasting disorder, has been identified as FGF-23, protein that shares sequence homology with fibroblast growth factors (FGFs). Patients ADHR display many of the clinical and laboratory characteristics are observed patients oncogenic osteomalacia (OHO), disorder thought to arise by secretion factor from different mesenchymal tumors. In present studies, we therefore investigated whether FGF-23 is secreted it...
Background Although increasingly used, the benefit of surgical treatment displaced 2-part proximal humerus fractures has not been proven. This trial evaluates clinical effectiveness surgery with locking plate compared non-operative for these fractures. Methods and findings The NITEP group conducted a superiority, assessor-blinded, multicenter randomized in 6 hospitals Finland, Estonia, Sweden, Denmark. Eighty-eight patients aged 60 years or older (more than 1 cm 45 degrees) anatomical neck...
Fibroblast growth factor-23 (FGF23), a circulating protein produced in bone, causes decreased renal inorganic phosphate (Pi) reabsorption by reducing the expression of sodium cotransporter type 2a (Npt2a). We have previously generated transgenic mice expressing human wild-type (WT) FGF23 under control alpha1 (I) collagen promoter.In this study, we performed large-scale gene study kidneys from and WT littermates. Microarray data key transcripts were verified real-time RT-PCR analysis.Several...
Domestication is one of the strongest forms short-term, directional selection. Although selection typically only exerted on or a few target traits, domestication can lead to numerous changes in many seemingly unrelated phenotypes. It unknown whether such correlated responses are due pleiotropy linkage between separate genetic architectures. Using three intercrosses wild and domestic chickens, locus affecting comb mass (a sexual ornament chicken) several fitness traits (primarily medullary...
Birds have a unique bone physiology, due to the demands placed on them through egg production. In particular their medullary serves as source of calcium for eggshell production during lay and undergoes continuous rapid remodelling. We take advantage fact that traits diverged massively chicken domestication map genetic basis metabolism in chicken. performed quantitative trait locus (QTL) expression QTL (eQTL) mapping study an advanced intercross based Red Junglefowl (the wild progenitor...
The culture of osteoblast-like cells human origin has become an important experimental model in bone biology. We report here a comparison and evaluation three the most widely used systems available today: marrow stroma cell cultures (BMSC), osteoblast explant (hOB) from collagenase-treated (hOBcol). Cultures 16 specimens obtained various donors were established their expression phenotype then compared secondary by use biochemical markers. BMSC had highest basal 1,25-dihy-droxyvitaminD3...
Fibroblast growth factor-23 (FGF23) is a circulating factor involved in phosphate (Pi) and vitamin D metabolism. Serum FGF23 increased at later stages of chronic kidney disease due to hyperphosphatemia decreased renal clearance. Recent studies also indicate that may directly regulate the expression parathyroid hormone (PTH) vitro. Therefore, objective current study was determine relationship between FGF23, PTH, other biochemistries vivo subjects with no history disease.Serum were measured...
Hyaluronic acid-based hydrogels are proven biocompatible materials and excellent carriers of bone morphogenetic protein-2 (BMP-2) that have been successfully tested for generation in vivo. Different formulations, with or without nanohydroxyapatite, shown promise craniofacial applications. In this study, 28 rats were used to investigate whether it is possible achieve mandibular augmentation upon injection novel hyaluronic containing nanohydroxyapatite different concentrations BMP-2 (0, 5 150...
We investigated the effects of various pro-inflammatory cytokines on proliferation rate isolated human osteoblastic cells in primary cultures.lnterleukin-1ß (IL-1ß) and tumor necrosis factor-ß (TNF-ß) time- dose-dependently enhanced osteoblasts. Both these also endogenous prostaglandin E2 (PGE2) formation. Exogenous PGE2 dose- time-dependently – stimulated cell proliferation. However, stimulatory IL-1ß TNF-ß osteoblast were not abolished by indomethacin, indicating a direct effect TNF-α at...
Abstract Sexual selection and the ornaments that inform such choices have been extensively studied, particularly from a phenotypic perspective. Although more is being revealed about genetic architecture of sexual ornaments, much still remains to be discovered. The comb chicken one most widely recognized which has shown correlated with both fecundity bone allocation. In this study, we use combination multiple intercrosses between W hite L eghorn populations wild‐derived Red Junglefowl to,...
Abstract XLH in humans and the Hyp phenotype mice are caused by inactivating Phex mutations. Overexpression of human PHEX under β-actin promoter rescued bone almost completely, but did not affect phosphate homeostasis, suggesting that different, possibly independent, pathophysiological mechanisms contribute to hyperphosphaturia abnormalities XLH. Introduction: Mutations PHEX, a phosphate-regulating gene with homologies endopeptidases on X chromosome, responsible for X-linked hypophosphatemia...
The development of biomaterial for bone regeneration requires animal models that are reliable and designed to mimic clinically relevant situations. We have previously investigated hydrogels comprised modified hyaluronic acid polyvinyl alcohol in ectopic formation. This hydrogel induces when loaded with morphogenetic proteins (BMPs). To allow further optimization hydrogels, we developed a new, femoral, non-critical-sized cortical defect model. In the rat femur, drilled standardized, elongated...
Background Proximal humerus fractures (PHFs) are common fractures, especially in older female patients. These commonly treated surgically, but the consensus on best treatment is still lacking. Methods and findings The primary aim of this multicenter, randomized 3-arm superiority, open-label trial was to assess results nonoperative operative either with locking plate (LP) or hemiarthroplasty (HA) 3- 4-part PHF outcome Disabilities Arm, Shoulder, Hand (DASH) at 2-year follow-up. Between...
Operative treatment is widely used for acute proximal hamstring avulsions, but its effectiveness compared with that of nonoperative has not been shown in randomized trials.