A5073194601- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Economic and Financial Impacts of Cancer
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Gut microbiota and health
- Atherosclerosis and Cardiovascular Diseases
- Genomics and Rare Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Viral-associated cancers and disorders
- Advances in Oncology and Radiotherapy
- RNA modifications and cancer
- Stress Responses and Cortisol
- BRCA gene mutations in cancer
- Chemokine receptors and signaling
- Biomedical Ethics and Regulation
- Cervical Cancer and HPV Research
University of Puerto Rico System
2021-2024
Sylvester Comprehensive Cancer Center
2023
University of Puerto Rico, Medical Sciences Campus
2018
Background: The incidence of sporadic colorectal cancer (CRC) among individuals <50 years (early-onset CRC) has been increasing in the United States (U.S.) and Puerto Rico. CRC is currently leading cause death Hispanic men women living Rico (PRH). objective this study was to characterize molecular markers clinicopathologic features tumors from PRH better understand pathways subpopulation. Methods: Microsatellite instability (MSI), CpG island methylator phenotype (CIMP), KRAS BRAF mutation...
Abstract Backgorund Colorectal cancer (CRC) is among the leading causes of cancer‐related deaths Hispanics living in United States (USH). Understanding most common carcinogenic molecular pathways that affect with CRC crucial to guide research efforts developing new therapeutic modalities incorporating genomically diverse populations. Tumor profiling techniques help identify actionable alternatives recommend treatment and improve survival patients. Methods We conducted a secondary data...
Abstract The discovery of innovative cancer prevention and treatment approaches relies on voluntary participation in clinical trials (CTs); however, remains low among minorities/ethnic groups. Knowledge CTs has been reported as a barrier to CT participation. Yet, there is limited understanding regarding knowledge gastrointestinal (GI) survivors Puerto Rico (PR). Colorectal the second leading cause death PR, accounting for 13% men women. We aimed describe factors associated with...
Abstract Despite significant advances in cancer prevention, early detection, and treatment, there is a persistent disparity outcomes between diverse racial/ethnic groups medically underserved populations the United States (US). The underrepresentation of non-white clinical trials (CTs) poses critical challenge to research effective care delivery. Hispanic/Latino population one fastest-growing ethnic US has high rate gastrointestinal (GI) cancer. Although Hispanics/Latinos comprise 18.5%...
Abstract Gastric cancer (GC) is the 4th leading cause of death globally. The incidence and mortality rates GC differ dramatically between racial/ethnic groupings. In United States (U.S.), Hispanics, non-Hispanic Blacks, Asian or Pacific Islanders are more likely to be diagnosed with have a higher rate than Whites. Among Hispanic population living in Puerto Rico (PRH), ranks among top ten causes death, whereas this malignancy not major mainland U.S. Tumor profiling approaches resulted...
Abstract Colorectal cancer (CRC) is a leading cause of death among men and women in Puerto Rico the United States. About 60-70% CRC cases are found at advanced stages (III/IV), suggesting limited adherence to available screening methods. Several molecular biomarkers have been identified as discriminatory for (e.g., KRAS, NRAS, MSI), improving management patient outcomes. This study evaluates differential expression patterns DKK3, PKM2, IGFBP2, SEPT9 genes between matched tumors adjacent...
Abstract Lynch syndrome (LS) is an autosomal dominant condition caused by germline mutations in DNA mismatch repair pathway genes that predispose individuals to develop colorectal cancer (CRC) and other malignancies. Not all LS patients CRC, age at diagnosis varies significantly, even among with identical mutations. Although several prospective genetic modifiers have been reported, the contribution of environmental exposures carcinogenesis onset unknown. The gut microbiota composition,...
Background: Colorectal cancer (CRC) is a leading cause of death worldwide. Despite its preventability through screening, compliance still needs to improve due the invasiveness current tools. There growing demand for validated molecular biomarker panels minimally invasive blood-based CRC screening. This study assessed diagnostic accuracy four promising biomarkers, individually and in combination. Methods: case–control involved plasma samples from 124 cases age- sex-matched controls....
Abstract Background Tumor molecular profiling techniques, such as next-generation sequencing (NGS) to identify somatic genetic alterations, allow physicians have a better understanding of the affected carcinogenic pathways and guide targeted therapy. The objective our study was characterize common alterations among Puerto Rican Hispanics with solid tumors. Methods We conducted single-institution, retrospective tumor profiles using 592-gene NGS platform. Actionable mutations current or...
Abstract Breast cancer (BC) has the highest incidence and mortality rates among Puerto Rican women. However, representation of Hispanics living in Rico (PRH) breast clinical trials may be limited due to lack a defined genetic profile from BC tumors patients. Mutations genes associated with tumor suppressors, progression, genome stability are shared all BCs. Nonetheless, differences frequency these mutations have been observed racial/ethnic groups. This study aims characterize genomic...
Abstract Despite evidence suggesting that current Colorectal Cancer (CRC) screening strategies reduce mortality rates, compliance is suboptimal; for this, our study aimed to evaluate the discriminatory potential of plasma cytokine and chemokine levels CRC detection in samples a Hispanic subpopulation. Using retrospective case-control design, we evaluated 20 cases age-gender matched controls from Puerto Rico Familial Registry (PURIFICAR). BD CBA Human Th1/Th2/Th17 Cytokine Chemokine kits were...
Abstract Cancer is the leading cause of morbidity and mortality in Puerto Rico (PR). The development novel, comprehensive, more accessible methods for interrogating tumors, including next-generation sequencing (NGS) to profile opened a window into drivers mutations oncologic patients. Although some studies have been done among Caucasian European patients, comprehensive genetic profiling cancer patients PR has not performed. A retrospective study design with data from CARIS Life Sciences...
Abstract Introduction: Colorectal cancer (CRC) is the 1st and 2nd leading cause of death in men women Puerto Rico U.S., respectively. A dynamic balance between host immune system gut bacterial communities essential to protect colonic tissues against chronic inflammation, which may lead CRC. The main goal this study was investigate if SNPs promoter regions IL-1β, IL-6 IL-10, key cytokines that regulate increase risk for colorectal adenomas by enriching a subset toxin-producing microbiota...
Abstract Background: Breast cancer is the most commonly diagnosed and first leading of related deaths among Hispanic women. The use technologies, such as next generation sequencing (NGS), have led to discovery tumor biomarkers that are currently being used guide personalized treatments improve overall survival. Although several studies characterized breast tumors in Caucasian European patients, a comprehensive genetic profiling from Puerto Rican Hispanics (PRH) has not been performed. In...
Abstract Background: Colorectal cancer (CRC) is one of the leading causes cancer-related deaths among men and women third cause in US. Tumor profiling techniques have led to identification actionable alterations guide treatment improve survival patients. However, comprehensive genetic colorectal tumors from Hispanics living Puerto Rico (PRH) has not been performed. Our study aimed at understanding common CRC carcinogenic molecular pathways that affect our Hispanic population by evaluating...
Abstract Background: Single nucleotide polymorphisms (SNPs) in IL-6, IL-1β, and IL-10 genes have been reported to impact infectious disease outcomes are associated with altered emotional states. High levels of these cytokines, which a role regulating inflammation, detected among individuals severe COVID-19 disease. The objective this study was examine if pro-inflammatory SNPs the promoter region more and/or increased anxiety/stress response pandemic-associated stressors vulnerable Hispanic...
Abstract Background: Colorectal cancer (CRC) is the second and third most common diagnosed in males females, respectively, leading cause of cancer-related deaths Puerto Rico (PR). This differs from USA, were CRC commonly for men woman, respectively. a heterogeneous disease genetic characteristics tumors are considered to evaluate prognostic outcome selection targeted therapies. Currently, techniques such as next-generation sequencing (NGS) being used tumor profiling, order classify identify...
Abstract Background: In the United States, lung cancer accounted for approximately one-quarter of all deaths; meanwhile, it was reported as second cause death in Puerto Rico (PR) 2018. Worldwide, development new technologies such next-generation sequencing (NGS) has allowed describing profile tumors and identifying mutation drivers oncologic patients. The information on these is limited Rican Hispanics (PRH). Methods: Using retrospective data from CARIS Life Sciences 2015 to 2020, we were...