A5085243947- Advanced Nanomaterials in Catalysis
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Histone Deacetylase Inhibitors Research
- MXene and MAX Phase Materials
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Graphene and Nanomaterials Applications
- MicroRNA in disease regulation
Hainan Medical University
2022-2024
Oxidative stress and reactive oxygen species drive ischemic stroke its related complications. New antioxidant medications are therefore crucial for treating stroke. We developed Ti2C@BSA-ISO nanocomposites loaded with the hydrophobic drug isoquercetin (ISO) encapsulated in BSA on Ti2C nano-enzymes as a novel therapeutic nanomedicine treatment of targeting (ROS). TEM visually proved successful preparation Ti2C@BSA-ISO, FTIR, XPS, zeta potential DLS together demonstrated acquisition...
Long noncoding RNA taurine-upregulated gene 1 (TUG1) is considered to be involved in postischemic cerebral inflammation, whereas polysialic acid (polySia, PSA), the product of St8sia2, constitutes polysialylated neural adhesion cell molecule (PSA-NCAM) both mice and humans that PSA-NCAM level elevated neuronal progenitor cells response transient focal ischemia. Herein, we aim identify novel miRNAs bridge functions St8sia2 TUG1 ischemia-associated injuries. In vivo (C57BL/6J mouse...
Epigenetic histone methylation plays a crucial role in cerebral ischemic injury, particularly the context of stroke. However, complete understanding regulators involved methylation, such as Enhancer Zeste Homolog 2 (EZH2), along with their functional effects and underlying mechanisms, remains incomplete.Here, we employed rat model MCAO (Middle artery occlusion) an OGD (Oxygen-Glucose Deprivation) primary cortical neurons to study EZH2 H3K27me3 ischemia-reperfusion injury. The infarct volume...