A5024201587- Wound Healing and Treatments
- Extracellular vesicles in disease
- Advancements in Transdermal Drug Delivery
- Cancer-related molecular mechanisms research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Endometriosis Research and Treatment
- MicroRNA in disease regulation
- Antiplatelet Therapy and Cardiovascular Diseases
- Nerve injury and regeneration
- Ovarian cancer diagnosis and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Endometrial and Cervical Cancer Treatments
- Protein Tyrosine Phosphatases
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Bone Metabolism and Diseases
- Phytochemistry and Bioactive Compounds
- Antimicrobial agents and applications
- Graphene and Nanomaterials Applications
- Medicinal Plant Pharmacodynamics Research
- Ginseng Biological Effects and Applications
- Antimicrobial Peptides and Activities
- Advanced Drug Delivery Systems
Hainan Medical University
2024
Tongji University
2022-2024
Shanghai Skin Disease Hospital
2022-2024
Macrophages play a pivotal role in the healing of diabetic ulcers. The sustained elevation glucose levels damages insulin signaling pathway macrophages, leading to dysfunctional macrophages that struggle transition from pro-inflammatory (M1) reparative (M2) states. Therefore, modulating macrophage inflammatory responses via holds promise for ulcer treatment. Additionally, presence biofilm impedes drug penetration, and resulting immunosuppressive microenvironment exacerbates persistent...
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age. Cryptotanshinone (CRY) has been shown to be effective reversing reproductive disorders, but whether it can used treatment polycystic remains unclear. We aimed explore mechanism cryptotanshinone driven via regulating ferroptosis. A rat model PCOS was established by daily injection human chorionic gonadotropin and insulin for 22 days. An vitro ischemia-reperfusion (IR) granulosa cells...
Oxidative stress and reactive oxygen species drive ischemic stroke its related complications. New antioxidant medications are therefore crucial for treating stroke. We developed Ti2C@BSA-ISO nanocomposites loaded with the hydrophobic drug isoquercetin (ISO) encapsulated in BSA on Ti2C nano-enzymes as a novel therapeutic nanomedicine treatment of targeting (ROS). TEM visually proved successful preparation Ti2C@BSA-ISO, FTIR, XPS, zeta potential DLS together demonstrated acquisition...
Abstract Osteoarthritis (OA) is marked by cartilage deterioration, subchondral bone changes, and an inflammatory microenvironment. The study introduces the Microneedle‐Delivered Polydopamine‐Exosome (PDA@Exo MN), a therapeutic that not only preserves promotes regeneration but also improves localized drug delivery through enhanced penetration capabilities. PDA@Exo MN shows strong reactive oxygen species (ROS) scavenging abilities high biocompatibility, fostering osteogenesis balancing...
Abstract Inspired by the experience of relieving inflammation in infants with milk, antioxidant‐engineered milk‐derived extracellular vesicles (MEVs) are developed to evaluate their potential for accelerating wound healing. In this work, MEVs polydopamines (PDA) engineered using co‐extrusion method. Subsequently, authors incorporated them into a Schiff‐based crosslink hydrogel, forming skin dosage form that could facilitate healing process. The antioxidant properties PDA assist...
Diabetic atherosclerosis is one of the main causes morbidity and mortality worldwide, but its therapeutic options are limited. Liraglutide (LIR), a synthetic analog GLP-1 approved as an anti-obesity drug by FDA, has been reported promising for diabetic atherosclerosis. However, problem with LIR use that requires regular parenteral injections, which necessitates improvement delivery increased efficiency minimization injection numbers. The objective our present study was to prepare...
Long noncoding RNA taurine-upregulated gene 1 (TUG1) is considered to be involved in postischemic cerebral inflammation, whereas polysialic acid (polySia, PSA), the product of St8sia2, constitutes polysialylated neural adhesion cell molecule (PSA-NCAM) both mice and humans that PSA-NCAM level elevated neuronal progenitor cells response transient focal ischemia. Herein, we aim identify novel miRNAs bridge functions St8sia2 TUG1 ischemia-associated injuries. In vivo (C57BL/6J mouse...
Epigenetic histone methylation plays a crucial role in cerebral ischemic injury, particularly the context of stroke. However, complete understanding regulators involved methylation, such as Enhancer Zeste Homolog 2 (EZH2), along with their functional effects and underlying mechanisms, remains incomplete.Here, we employed rat model MCAO (Middle artery occlusion) an OGD (Oxygen-Glucose Deprivation) primary cortical neurons to study EZH2 H3K27me3 ischemia-reperfusion injury. The infarct volume...
Polycystic ovary syndrome (PCOS) is a common disease affecting women of reproductive age; there need for interventions to address this condition. Herein, the network pharmacology approach was used explore potential combining Morindae Officinalis Radix (Bajitian) and Salviae (Danshen) treating PCOS. The bioactive ingredients Bajitian-Danshen pair were identified predicting therapeutic target genes. Genes related PCOS predicted by keyword search from various databases intersected with targets...
<title>Abstract</title> Macrophages play a pivotal role in the healing of diabetic ulcers. The sustained elevation glucose levels damages insulin signaling pathway macrophages, leading to dysfunctional macrophages that struggle transition from pro-inflammatory (M1) reparative (M2) states. Therefore, modulating macrophage inflammatory responses via holds promise for ulcer treatment. Additionally, presence biofilm impedes drug penetration, and resulting immunosuppressive microenvironment...
<title>Abstract</title> Background Diabetic atherosclerosis is one of the main causes morbidity and mortality worldwide, but its therapeutic options are limited. Liraglutide (LIR), a synthetic analog GLP-1 approved as an anti-obesity drug by FDA, has been reported promising for diabetic atherosclerosis. However, problem with LIR use that requires regular parenteral injections, which necessitates improvement delivery increased efficiency minimization injection numbers. Results The objective...