A5049919574- Fungal and yeast genetics research
- Plant nutrient uptake and metabolism
- Plant Stress Responses and Tolerance
- DNA Repair Mechanisms
- Nuclear Structure and Function
- Genomics, phytochemicals, and oxidative stress
- Trace Elements in Health
- 14-3-3 protein interactions
University of Gothenburg
2025
Czech Academy of Sciences, Institute of Physiology
2022-2023
Czech Academy of Sciences
2022-2023
ABSTRACT Human exposure to arsenicals is associated with devastating diseases such as cancer and neurodegeneration. At the same time, arsenic-based drugs are used therapeutic agents. The ability of arsenic directly bind proteins correlated its toxic effects highlighting importance elucidating arsenic-protein interactions. In this study, we took a proteomic approach identified 174 that in Saccharomyces cerevisiae . Proteins involved nucleocytoplasmic transport were markedly enriched among...
Yeasts need a high intracellular concentration of potassium to grow. The main K+ uptake system in Saccharomyces cerevisiae is the Trk1 transporter, complex protein with four MPM helical membrane motifs. has been shown exist low- or high-affinity modes, which reflect availability environment. However, when and how affinity changes, whether only signal for switch, remains unknown. Here, we characterize kinetic parameters under various conditions find that Trk1's KT Vmax change gradually. This...
The existence of programmed cell death in Saccharomyces cerevisiae has been reported for many years. Glucose induces the S. absence additional nutrients within a few hours, and active potassium uptake makes cells highly sensitive to this process. possess two transporters, Trk1 Trk2, which ensure high intracellular concentration potassium, necessary physiological processes. is major system responsible acquisition growing dividing cells. contribution Trk2 almost negligible, but becomes crucial...