A5023213972- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Musculoskeletal pain and rehabilitation
- Metabolomics and Mass Spectrometry Studies
- Neurotransmitter Receptor Influence on Behavior
- Pain Management and Opioid Use
- Adipose Tissue and Metabolism
- Aquatic Ecosystems and Phytoplankton Dynamics
- Ion Transport and Channel Regulation
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Dental Health and Care Utilization
- Mesenchymal stem cell research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Liver physiology and pathology
- Redox biology and oxidative stress
- Nutrition and Health in Aging
- Animal Nutrition and Physiology
- Cannabis and Cannabinoid Research
The People's Hospital of Guangxi Zhuang Autonomous Region
2022-2024
Shaanxi Provincial People's Hospital
2024
Shanxi Medical University
2024
Guiyang Medical University
2023
Van Andel Institute
2017-2023
Shanghai University of Medicine and Health Sciences
2021-2022
Central South University
2016-2020
Xiangya Hospital Central South University
2016-2020
Dongfeng Motor Group (China)
2018-2020
Chongqing University of Education
2020
Growth factors, such as insulin, can induce both acute and long-term glucose uptake into cells. Apart from the rapid, insulin-induced fusion of transporter (GLUT)4 storage vesicles with cell surface that occurs in muscle adipose tissues, mechanism behind induction has been unclear other systems. Thioredoxin interacting protein (TXNIP) shown to be a negative regulator cellular uptake. TXNIP is transcriptionally induced by reduces influx promoting GLUT1 endocytosis. Here, we report direct...
Adherence to disease-modifying therapies (DMTs) results in the reduction of number and severity relapses delays progression multiple sclerosis (MS). Patients with lower adherence rates experience more inpatient visits higher MS-related medical costs. Fingolimod, first oral DMT approved by US Food Drug Administration, may improve access compliance MS treatment when compared injectable DMTs. This retrospective cohort study used pharmacy claims from Medco Health Solutions, Inc., patients who...
Topic modeling is a crucial technique in natural language processing (NLP), enabling the extraction of latent themes from large text corpora. Traditional topic modeling, such as Latent Dirichlet Allocation (LDA), faces limitations capturing semantic relationships document although it has been widely applied mining. BERTopic, created 2022, leveraged advances deep learning and can capture contextual between words. In this work, we integrated Artificial Intelligence (AI) modules to LDA BERTopic...
There exist similarities and differences in metabolism physiology between normal proliferative cells tumor cells. Once a cell enters the cycle, metabolic machinery is engaged to facilitate various processes. The kinetics regulation of these changes have not been properly evaluated. To correlate orchestration processes with we analyzed transition from quiescence proliferation non-malignant murine pro-B lymphocyte line response IL-3. Using multiplex mass-spectrometry-based proteomics, show...
Mesenchymal stem cells (MSCs) hold promise as cellular vehicles for the delivery of therapeutic gene products because they can be isolated, expanded, and genetically modified in vitro possess tumor-oriented homing capacity vivo. (1) Hepatocyte nuclear factor 4α (HNF4α) is a dominant transcriptional regulator hepatocyte differentiation hepatocellular carcinogenesis (HCC). (2,3) We have previously demonstrated that overexpression HNF4α activates various hepatic-specific genes enhances MSC...
Background Studies relating obesity to cognition in older people show conflicting results, which may be explained by the choice of indicators. Objectives This study aimed investigate relationship between obesity-related indicators and cognitive impairment, especially different age or gender subgroups, explore whether were related specific domains. Methods was a cross-sectional on 1753 participants aged ≥ 60 years (41.0% men; 71.36 ± 5.96 years). Obesity-related included body mass index...
Objective:Describe characteristics of diabetic patients who initiated basal insulin and assess their glycemic control.Research design methods:Physician encounters in the General Electric EMR Database (2005–2010) were assessed for with type II diabetes (T2DM) between February 2006 August 2009, initiation defined as no prescription record prior 15 months. Patients followed an average 2.5 years after initiation. The proportion time to achieving HbA1c ≤ 7% ('goal') assessed. Among reached goal,...
Trigeminal neuralgia (TN) is a rare orofacial disorder characterized by severe unilateral paroxysmal pain in the region of fifth cranial nerve. Clinical guidelines recommend carbamazepine (only US Food and Drug Administration-approved drug for TN) oxcarbazepine as first-line therapies. We utilized Truven Health MarketScan database to examine treatment patterns among patients with TN.Included were aged 18 years above, newly diagnosed TN (≥2 diagnoses ≥14 days apart; no diagnosis previous...
Hyperglycemia affects over 400 million individuals worldwide. The detrimental health effects are well studied at the tissue level, but in vivo organelle level poorly understood. To establish such an model, we used mice lacking TXNIP, a negative regulator of glucose uptake. Examining mitochondrial function brown adipose tissue, find that TXNIP KO have lower content polyunsaturated fatty acids (PUFAs) their membrane lipids, which integrity and electron transport chain efficiency ultimately...
Abstract Imidazoline receptor antisera‐selected protein (IRAS) is considered as a candidate for the I 1 ‐imidazoline (I R), but signaling pathway mediated by IRAS remains unknown. In our study, signal transduction pathways of were investigated in CHO cells stably expressing (CHO‐IRAS), and compared to native R pathways. Rilmenidine or moxonidine (10 nM–100 µM), agonists, failed stimulate [ 35 S]‐GTPγS binding CHO‐IRAS cell membrane preparations, suggesting that G may not be involved pathway....