Abstract Objectives To assess acceptability of teleconsultation among the socioeconomically marginalized sections patients with rheumatic and musculoskeletal diseases (RMDs), to identify socioeconomic barriers in continuing rheumatology care during COVID-19 crisis who could benefit by shifting tele-rheumatology consultations. Methods This was a cross sectional analytical study done at tertiary teaching hospital India including RMDs were not on biological modifying agents. Assessment disease...

This study aimed to test whether immunosuppressant (IS) withdrawal is noninferior glucocorticoid (GC) in patients with Systemic Lupus Erythematosus (SLE) remission. In this open-label, single-center, randomized (1:1) controlled trial, we compared flare occurrence stable SLE undergoing GC or IS tapering. Patients aged >18, on (prednisolone ≤7.5 mg/day) and maintenance non-biological for ≥3 years, clinical remission ≥1 year, were enrolled assigned taper over 3 months. The primary end point was...

Abstract Background/Aims Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus (SLE). About 14-33% LN patients fail to respond standard treatment. In this study we evaluated the treatment outcomes who failed first-line immunosuppressives and attempted define clinical characteristics ‘difficult-to-treat’ (DTT) LN. Methods Records all SLE from clinic in our center underwent renal biopsy were reviewed. Those with class III, IV, V included. Demographic, clinical,...

<h3>Background:</h3> Ultrasonography can measure vascular intimal-medial thickness (IMT) and delineate the degrees of stenosis in Takayasu arteritis (TAK). Further, higher IMT has been reported patients with active disease, prospective studies showing changes carotid treatment. A cross-sectional study attempted derivation a score incorporating values at different arterial sites that correlated disease activity(2). In this we measured multiple enrollment six months tried to correlate...

<h3>Background:</h3> Rituximab(RTX) is increasingly being employed to treat refractory systemic lupus erythematosus(SLE). Though the drug effective there a high risk of adverse events including infections. Most trial data have focused only on short term(&lt;1 year) safety and long term follow-up lacking. This study was designed look at frequency predictors infections in patients with SLE who are follow up. <h3>Objectives:</h3> 1.To assess outcomes Rituximab therapy 2.Describe profile...

<h3>Background:</h3> Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus (SLE). About 14-33% LN fail to respond standard treatment [1, 2]. In this study, we evaluated the outcomes who failed first-line immunosuppressives and identified clinical characteristics 'difficult-to-treat' (DTT LN). <h3>Objectives:</h3> 1)To evaluate prevalence demographic patients with DTT LN. 2)To explore factors determining 3)To compare mortality renal between responsive forms...

Objective: The study aimed to evaluate serum biomarkers (Galectin-9, TNFRII, APRIL, CXCL10, and BAFF) for their utility in identifying disease activity idiopathic inflammatory myopathies (IIM) Methods: We enrolled adult patients who satisfied the 2017 EULAR/ACR criteria IIM categorised them into active (n = 16) inactive 24) subgroups. Inactive was defined as absence of global extramuscular activity, stable manual muscle testing 8 (MMT-8), normal enzymes over at least 6 months. measured by...

Background: To longitudinally evaluate muscle changes using thigh-magnetic resonance imaging (MRI) scores and dual-energy X-ray absorptiometry (DXA) assessed body composition indices, correlating with clinical outcomes in active idiopathic inflammatory myositis (IIM) patients over 6 months. Methods: A single-centre prospective study involving 20 IIM patients. Clinical outcomes, enzymes, MRI of the thigh were periodically Results: Muscle oedema score significantly decreased from baseline...

Abstract Objectives To evaluate the relationship of thigh MRI (t-MRI) with manual muscle testing-8 (MMT-8), enzymes and autoantibodies. determine causal mediating factors resulting in poor recovery MMT-8 inflammatory myositis (IIM). Methods This was a single-centre retrospective study IIM patients. t-MRI semi-quantitatively scored for oedema, fascial atrophy fatty infiltration. Spearman correlation scores done at baseline, baseline on follow-up. Causal mediation analysis performed age, sex,...

Objectives: To assess the performance of clinical and biochemical parameters in identifying renal histopathology. a combination demographic, clinical, serological histopathological determining response at one year. Methods: Data biopsy-proven (ISN/RPS—2003 criteria) Lupus Nephritis (LN) were extracted from institute database. Demographic, time biopsy noted, their associations with class, activity chronicity scores evaluated. Follow-up data year collected. Complete, partial or no (CR, PR, NR)...

Objective: The objective of this study is to identify factors associated with active tuberculosis (TB) in patients systemic lupus erythematosus (SLE) and the impact TB on SLE disease activity. Methodology: We screened case records 643 individuals for diagnosis TB. (cases) (n = 29) were matched age, sex, duration ratio 1:3 controls 94) (SLE without TB). Results: Pulmonary was seen 41% 12) extrapulmonary 59% 17). Musculoskeletal 6; 34.2%) most common manifestation. among those nephritis (55%...

<h3>Background</h3> Attempts to stop glucocorticoids (GC) among lupus patients in long term remission have been successful. Continuing other immunosuppressive (IS) agents indefinitely is currently the norm and this approach results significant infectious, psychological economic burden on patients. Moreover, there no pathophysiological basis withdraw GC over IS agents, except for indirect evidence of higher adverse effects with continued low dose use. Hence, a need assess, if taper steroids...

<h3>Background</h3> Cardiovascular disease (CVD) is a major cause of mortality in systemic lupus erythematosus (SLE) with standardized ratio 2.4, that underestimated by conventional CVD risk scores. Subclinical atherosclerosis, predictor cardiovascular morbidity an important target for primary prevention. Carotid intima media thickness (cIMT) and plaques are frequently used measures subclinical atherosclerosis. Role scores which look at events, assessment stratification atherosclerosis SLE...

<h3>Background</h3> Cardiovascular disease (CVD) is a major cause of mortality in systemic lupus erythematosus (SLE). Role conventional risk scores which look at cardiovascular events, assessing subclinical atherosclerosis SLE not fully established. This study aims to assess performance QRESEARCH database score-3 (QRISK3), coronary evaluation (SCORE) and WHO (World Health Organization) CVD determine clinical associations the same. <h3>Methods</h3> single center cross-sectional analytical...

Background Diagnosis of Lupus Nephritis (LN) is currently based on laboratory tests and renal histopathology. Role histopathological features in determining long term outcomes unclear. Objectives 1. To assess if clinical biochemical parameters at baseline can identify class. 2. the clinico-histopathological predictors response. Methods This a single centre retrospective study comprising 334 LN biopsies. Clinical time biopsy were noted their association with class, activity chronicity scores...

Background: To evaluate the relationship of thigh magnetic resonance imaging (t-MRI) scores with muscle strength, enzymes and autoantibodies. determine demographic, clinical serological factors resulting in poor recovery strength (power) mediated via t-MRI findings inflammatory myositis (IIM).Methods: The study was a single center retrospective involving IIM patients who underwent at baseline. Demographic variables baseline maximum MMT-8 achieved during follow-up were documented. semi...

<h3>Background/Purpose</h3> Diagnosis of Lupus Nephritis (LN) is currently based on laboratory tests and renal histopathology. The role histopathological features in determining long term outcomes unclear. objectives are to determine if clinical biochemical parameters at baseline could identify class assess the clinico-histopathological predictors response. <h3>Methods</h3> This a single centre retrospective study comprising 334 LN biopsies. Clinical time biopsy were noted their association...