A5065243928- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Autoimmune and Inflammatory Disorders Research
- Atherosclerosis and Cardiovascular Diseases
- Renal Diseases and Glomerulopathies
- Liver Diseases and Immunity
- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Pregnancy and Medication Impact
- Systemic Sclerosis and Related Diseases
- Mycobacterium research and diagnosis
- Cytokine Signaling Pathways and Interactions
- Muscle Physiology and Disorders
- Antimicrobial Resistance in Staphylococcus
- Spondyloarthritis Studies and Treatments
- Peripheral Neuropathies and Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vasculitis and related conditions
- Viral Infections and Immunology Research
- Bone and Joint Diseases
- Electrolyte and hormonal disorders
- Musculoskeletal synovial abnormalities and treatments
- Ion channel regulation and function
- Sepsis Diagnosis and Treatment
Jawaharlal Institute of Post Graduate Medical Education and Research
2016-2025
Dokkyo Medical University
2024
General Department of Preventive Medicine
2024
All India Institute of Medical Sciences
2006-2009
ABSTRACT Mechanisms contributing to non‐response treatment in lupus nephritis (LN) are unclear. We characterised the transcriptome of paired peripheral blood mononuclear cells (PBMCs) and renal tissues LN before after cyclophosphamide (CYC) identified markers that predicted response. Total RNA isolated from PBMCs ( n = 32) 25) 16 proliferative CYC treatment, 6 months post‐treatment, during flare, was sequenced on Illumina Novaseq‐6000 platform. Post‐treatment, eight patients were clinical...
This study aimed to test whether immunosuppressant (IS) withdrawal is noninferior glucocorticoid (GC) in patients with Systemic Lupus Erythematosus (SLE) remission. In this open-label, single-center, randomized (1:1) controlled trial, we compared flare occurrence stable SLE undergoing GC or IS tapering. Patients aged >18, on (prednisolone ≤7.5 mg/day) and maintenance non-biological for ≥3 years, clinical remission ≥1 year, were enrolled assigned taper over 3 months. The primary end point was...
Neurological melioidosis, caused by Burkholderia pseudomallei , is a rare but serious manifestation of melioidosis that can lead to significant morbidity and mortality. This case series highlights the clinical presentations, neuroimaging findings, management outcomes five adult patients diagnosed with isolated neurological between January 2019 June 2023. All exhibited subacute meningoencephalitis, hemiparesis, cerebellar signs. Neuroimaging studies revealed distinctive T2 hyperintensities...
Gut colonization with Vancomycin Resistant Enterococci (VRE) increases the risk of acquiring infection during hospital stay. Patients admitted in ICU's are major reservoirs for VRE due to higher antibiotic pressure.To determine rate among patients Medical Intensive Care Unit (MICU) and assess various factors which associated colonization.This was a prospective study carried out over period 18 months from September 2013 February 2015 Jawaharlal Institute Post graduate Education Research...
With prevalence of diabetes in India reaching epidemic proportions and increase the population geriatric age group risks falls, it is important to understand effect that has on bone health.The objective was assess mineral density (BMD) patients with type 2 mellitus (T2DM) study factors contributing BMD T2DM.This a prospective cross-sectional 150 T2DM (diagnosed at > 30 years) an equal number (n=150) sex matched healthy controls from September 2012 July 2014 tertiary care center located...
Cases of optic neuritis have been reported following the novel coronavirus disease 2019 (COVID-19), with most being unilateral and associated demyelinating illness. We report a case 22-year-old woman who presented sudden onset painless diminution vision in both eyes six weeks COVID-19 infection. She also had history left lower motor neuron (LMN) facial palsy immediately that recovered fully on steroids. Ocular examination ancillary laboratory investigations pointed to bilateral atypical...
Pattern of acute kidney injury (AKI) differs vastly from region to in India. Moreover, prospective data on community-acquired AKI (CAAKI) using the KDIGO criteria for are limited. Our objective was study etiology, clinical characteristics, and short-term outcome CAAKI adults.This a observational medical wards tertiary care hospital. Patients fulfilling 2012 community acquired were included. who developed 48 hours after admission, those hospitalized >48 elsewhere, patients with chronic...
Objectives In this study, we aimed to examine and analyze liver abnormalities among patients with systemic lupus erythematosus (SLE), including both newly diagnosed those being followed up, as well the prevalence of hepatitis. Methods This was a prospective observational study. Clinical data, function tests (LFTs), findings from ultrasonography abdomen were prospectively recorded evaluated. Results Overall, 28 total 135 (20.7%) had abnormalities, biochemical detected via ultrasonography. Ten...
The usefulness of anti-cyclic citrullinated peptide antibodies (anti-CCP antibodies) to identify rheumatic arthritis (RA) from other diseases presenting with joint pain is not well studied.We aimed determine the sensitivity and specificity anti-CCP in Indian RA patients respect non-RA study relationship IgG, IgM IgA rheumatoid factor RA.Case-control cross-sectional carried out rheumatology division All India Institute Medical Sciences.Sixty-three 51 having were included study. Sera tested...
Hyperemesis gravidarum is known to induce nutritional, water and electrolyte deficiencies which can be fatal if not treated urgently. Thiamine deficiency may lead a constellation of neurological symptoms that include Wernicke encephalopathy. Moreover, encephalopathy typically manifested as ocular paresis, ataxia confusion.Retrospective review 6 women who developed abnormalities following hyperemesis were with varying dosage parenteral thiamine.Five atypical symptoms, namely, slurred speech,...
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To assess the longitudinal effect of cyclophosphamide (CYC) treatment on type-I interferon (IFN) signature in proliferative lupus nephritis (LN) and its role predicting response.