A5081409474- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Vasculitis and related conditions
- Inflammatory Myopathies and Dermatomyositis
- Renal Diseases and Glomerulopathies
- Metabolomics and Mass Spectrometry Studies
- Infectious Diseases and Tuberculosis
- Immunodeficiency and Autoimmune Disorders
- Systemic Sclerosis and Related Diseases
- Atherosclerosis and Cardiovascular Diseases
- Adolescent and Pediatric Healthcare
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Sarcoidosis and Beryllium Toxicity Research
- Chronic Lymphocytic Leukemia Research
- Psoriasis: Treatment and Pathogenesis
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Peripheral Neuropathies and Disorders
- Lymphoma Diagnosis and Treatment
- Musculoskeletal Disorders and Rehabilitation
- Tuberculosis Research and Epidemiology
- Liver Disease Diagnosis and Treatment
KIIT University
2019-2025
Institute of Medical Sciences
2019-2025
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2014-2024
All India Institute of Medical Sciences Bhubaneswar
2021-2024
Institute of Medical Sciences and Sum Hospital
2021-2023
Center for Rheumatology
2021
Robert Bosch (Germany)
2019
Laboratoire de Chimie Moléculaire et Thioorganique
2019
Royal Australian Chemical Institute
2019
Christian Medical College & Hospital
2019
Objectives. There are no valid instruments to measure disease activity in Takayasu arteritis (TA). We aim provide a assess clinical with or without incorporating acute phase reactants. Methods. The Indian Clinical Activity Score (ITAS) was initially derived from manifestations scored the Disease Extent Index (DEI.Tak). ITAS validated by group of physicians scoring both live and paper cases for inter-rater reliability (IRR), convergence BVAS, correlation Physician’s Global Assessment (PGA)...
Objective. To evaluate the efficacy of tadalafil as add-on therapy in secondary RP resistant to vasodilators. Methods. Patients with scleroderma and MCTD having four or more attacks per week despite being on vasodilators were randomized receive either placebo (20 mg) alternate days their current for 6 weeks. After a 7-day washout, patients crossed over other arm. Primary endpoints improvement daily frequency duration episodes condition score (RCS). Secondary outcome measures healing existing...
Management of patient with Lupus Nephritis (LN) continues to remain a challenge for the treating physicians because considerable morbidity and even mortality. The search biomarkers in serum urine is focus researchers unravel new targets therapy. In present study, utility NMR-based metabolomics has been evaluated first time discriminating LN patients from non-nephritis lupus (SLE) further get insights into underlying disease processes better clinical management. Metabolic profiling sera...
Quality of life (QOL) patients affected by various diseases is now recognized as an important outcome variable. Consenting with rheumatoid arthritis (American College Rheumatology criteria) were included in the study. was assessed using World Health Organization Life assessment, short form (WHOQOL-BREF). Disease activity Activity Score (DAS28) for 3 variables and functional disability Assessment Questionnaire (HAQ). Extra-articular manifestations (ExRA) diagnosed clinically. Seventy-five...
Introduction. Th17, γδ T, NK, and NKT cells in peripheral blood serum IL-17 IL-23 Takayasu arteritis (TA) were measured correlated with disease activity. Methods. Th17 (anti-CD3APC, CD4PECy7, IL-17PE), NKT, NK CD56FITC), T (anti-CD3FITC TCRAPC) enumerated by flow cytometry of 30 patients TA (ACR1990 criteria) 20 healthy controls, ELISA. Relation activity (NIH criteria, ITAS2010) was analyzed (using nonparametric tests, median interquartile range). Results. Mean age was<mml:math...
Takayasu arteritis (TA) is a debilitating, systemic disease that involves the aorta and large arteries in chronic inflammatory process leads to vessel stenosis. Initially, remains clinically silent (or undetected) until patients present with vascular occlusion. Therefore, new methods for appropriate timely diagnosis of TA cases are needed start proper therapy on time also monitor patient's response given treatment. In this context, NMR-based serum metabolomic profiling has been explored...
Apoptosis of lymphocytes is increased in patients with lupus. This may be pathogenic leading to load autoantigens or a bystander effect immune activation. A major unresolved issue whether apoptosis related disease activity. Also its association lymphocyte frequencies, anti-nucleosomal antibodies and serum IL 10 levels needs explored further. The aims this study are measure T- B-lymphocyte lupus look at the activity cross-sectional longitudinal design determine frequency T B cells, level...
Abstract Objective There are sparse data on outcome of lupus nephritis from developing countries. This study looks at in Asian Indians. Methods retrospective included patients a single center over 20 years. Patients were treated as per standard protocols. The primary measure was chronic renal failure or death; the secondary end‐stage disease death. worst‐case scenario also calculated, considering those lost to followup first year events. Kaplan‐Meier survival curves and log rank test used...
Aim Methotrexate (MTX) has the potential to cause serious adverse reactions and even mortality. We analyzed predisposing factors outcome in patients with MTX-induced pancytopenia admitted into our unit from 1996 2015. Methods Patients were identified by departmental database search. Pancytopenia was defined as white blood cell count (WBC) < 3500 cells/mm3, hemoglobin (Hb) 11 g/dL platelet 150 000 cells/mm3. Severe WBC 2000 Hb 10 50 Results Forty-six included study (female = 35). Twenty-four...
Childhood SLE (cSLE) has a higher prevalence of lupus nephritis (LN), and there are ethnic variations in response to treatment as well outcome LN. There limited data on long-term LN cSLE from the Indian subcontinent.Retrospective analysis case records patients with (satisfying revised American College Rheumatology (ACR) 1997 criteria for diagnosis) age onset <18 years was conducted 1989 2013. Data clinical features, renal involvement biopsy findings, treatment, outcome, damage accrual...
The study was aimed at identification by proteomics and validation enzyme-linked immunosorbent assay (ELISA) of potential urinary biomarkers for lupus nephritis. Study subjects comprised 88 systemic erythematosus (SLE) patients 60 controls (rheumatoid arthritis, diabetes mellitus healthy individuals). Based on the SLE disease activity index (SLEDAI), were classified as active renal (AR), non-renal (ANR) or inactive (ID). Urinary proteins from a group with AR ID resolved two-dimensional gel...
Quality of life (QOL) patients affected by various diseases is now recognized as an important outcome variable. Consenting with rheumatoid arthritis (American College Rheumatology criteria) were included in the study. was assessed using World Health Organization Life assessment, short form (WHOQOL-BREF). Disease activity Activity Score (DAS28) for 3 variables and functional disability Assessment Questionnaire (HAQ). Extra-articular manifestations (ExRA) diagnosed clinically. Seventy-five...
Fibromyalgia (FM) has been shown to be common in patients with rheumatoid arthritis (RA), but studies on Asian are lacking. It remains unclear whether FM an adverse influence pain, fatigue, quality of life, and mood these patients, what its relationship is disease activity. We studied prevalence effects North Indian RA associations activity.This cross-sectional study included 200 equal number controls. Presence was defined using the American College Rheumatology 1990 criteria. Pain fatigue...