A5008269551- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Pleural and Pulmonary Diseases
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Nosocomial Infections in ICU
- Respiratory and Cough-Related Research
- Congenital Diaphragmatic Hernia Studies
- Inhalation and Respiratory Drug Delivery
- Pneumocystis jirovecii pneumonia detection and treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genetic factors in colorectal cancer
- Infant Development and Preterm Care
- Global Cancer Incidence and Screening
- Ethics and Legal Issues in Pediatric Healthcare
- Influenza Virus Research Studies
- Ethics in Clinical Research
- Trauma Management and Diagnosis
- Pediatric health and respiratory diseases
- Amino Acid Enzymes and Metabolism
- IL-33, ST2, and ILC Pathways
- Respiratory Support and Mechanisms
- Digestive system and related health
- Esophageal and GI Pathology
Sydney Children's Hospital
2010-2023
UNSW Sydney
2019
Sydney Children’s Hospitals Network
2011-2018
Mater Health Services
2017
ABSTRACT Objective: The aim of the study was to evaluate and compare faecal markers intestinal inflammation in children with cystic fibrosis (CF), determine whether adversely affects nutritional phenotype. Methods: Faecal samples for inflammation, calprotectin, S100A12, osteoprotegerin, were collected from CF, healthy controls (HCs), Crohn disease (CD). Associations between inflammatory clinical indices determined subjects CF. Results: Twenty‐eight CF (mean [standard deviation (SD)] 8.4...
An increase in the incidence of empyema worldwide could be related to invasive pneumococcal disease caused by emergent nonvaccine replacement serotypes. To determine bacterial pathogens and serotypes that cause children Australia, we conducted a 2-year study 174 with empyema. Blood pleural fluid samples were cultured, was tested PCR. Thirty-two (21.0%) 152 blood 53 (33.1%) 160 cultures positive for bacteria; Streptococcus pneumoniae most common organism identified. PCR identified S. 74...
Childhood interstitial lung disease (chILD) represents a rare heterogeneous group of respiratory disorders. In the absence randomized controlled clinical trials, global collaborations have utilized case series with an aim to standardising approaches diagnosis and management. Australasian data are lacking. The this study was calculate prevalence report experience chILD in Australasia over decade. Paediatric pulmonologists Australia New Zealand involved care patients aged 0–18 years completed...
Aims: To investigate the change in incidence of childhood empyema and pneumonia Australia, ascertain management trends all hospitals caring for children with empyema. Methods: The incidences were calculated each year between 1993/1994 2004/2005 using retrospective primary diagnostic coding from ICD‐9 10 comprising Australian National Hospital Morbidity Database five age groups patients less than 20 years age. Hospitals allocated paediatric beds surveyed on referral pattern treatment...
To examine rates of paediatric hospitalization for empyema and pneumonia in Australia before after the introduction seven-valent pneumococcal conjugate vaccine (PCV7).Rates (bacterial, viral all types) were calculated following codes International Classification Diseases, tenth revision (ICD-10) as a principal diagnosis. The expected number hospitalizations PCV7 was introduced estimated on basis observed PCV7. Incidence rate differences (IRDs) incidence ratios (IRRs) calculated....
The Pseudomonas aeruginosa quorum sensing signal molecule N-3-oxododecanoyl-l-homoserine lactone (3OC12HSL) can inhibit function of the mammalian anti-inflammatory transcription factor peroxisome proliferator activated receptor (PPAR)γ, and be degraded by human paraoxonase (PON)2. Because 3OC12HSL is detected in lungs cystic fibrosis (CF) patients infected with P. aeruginosa, we investigated relationship between infection gene expression PPARγ PON2 bronchoalveolar lavage fluid (BALF)...
Background Empyema is a serious complication of pneumonia frequently caused by Streptococcus pneumoniae (SP). We assessed the impact 13-valent pneumococcal conjugate vaccine (13vPCV) on childhood and empyema after inclusion in Australian National Immunisation Program. Methods For bacterial hospitalisations, we ascertained incidence rates (IRs) using Hospital Morbidity Database International Statistical Classification Disease discharge codes relevant population denominators, calculated rate...
National surveillance of invasive pneumococcal disease (IPD) includes serotyping Streptococcus pneumoniae (SP) isolates from sterile site cultures. PCR is more sensitive and can identify SP serotypes (STs) in culture-negative samples. The aim this study was to determine whether enhanced childhood empyema, using PCR, provides additional serotype information compared with conventional surveillance.Pleural fluid (PF) children empyema were cultured tested by SP, targeting the autolysin gene...
Abstract Background Empyema is a complication of pneumonia, commonly caused by Streptococcus pneumoniae . Aims To validate the utility an immunochromatographic test for detection S. antigen in pleural fluid children with empyema. Methods patients had blood and cultured, polymerase chain reaction (PCR) to detect autolysin gene, lytA , fluid. Pleural was tested using Binax NOW assay compared PCR results and/or culture or Results detected 68 137 (49.6%) patients, 11 135 (8.1%) specimens 16 120...
Much of what is known about the seasonality human rhinovirus (hRV) infections has been learned from study acute asthma exacerbations presenting to emergency care, including those among children at start school term. less patterns hRVs in community. In this study, viruses and day-to-day symptoms colds were monitored twice weekly 67 with aged 5-12 years, over a 15 month period Sydney, Australia. Overall hRV was detected 314/1232 (25.5%) nasal wash samples 142/1231 (11.5%) exhaled breath...
Standard of care recommend that patients with cystic fibrosis (CF) require screening investigations to assess for complications. Changing models due the COVID19 pandemic may have impacted completion recommended screening.To compare frequency completed in people CF before and after onset pandemic.Medical records were reviewed at 4 CF-specialist centers identify 12-months onset.Records 625 reviewed. Prior onset, there was between center variability investigations. There greatest baseline...