A5088927649- Cystic Fibrosis Research Advances
- Pancreatitis Pathology and Treatment
- Child Nutrition and Feeding Issues
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Neonatal Respiratory Health Research
- Gut microbiota and health
- Dysphagia Assessment and Management
- Pediatric Hepatobiliary Diseases and Treatments
- Simulation-Based Education in Healthcare
- Pancreatic and Hepatic Oncology Research
- Infant Development and Preterm Care
- Intestinal Malrotation and Obstruction Disorders
- Respiratory viral infections research
- Elbow and Forearm Trauma Treatment
- Orthopedic Surgery and Rehabilitation
- Chemical Reaction Mechanisms
- Synthesis and Reactions of Organic Compounds
- Infant Nutrition and Health
- Neonatal Health and Biochemistry
- Sarcoma Diagnosis and Treatment
- Innovations in Medical Education
- Gastroesophageal reflux and treatments
- Foot and Ankle Surgery
- Digestive system and related health
UNSW Sydney
2016-2025
Sydney Children's Hospital
2013-2025
Children's Hospital at Westmead
2017
University of Newcastle Australia
2017
John Hunter Children's Hospital
2017
The University of Sydney
2017
John Wiley & Sons (United States)
2017
University Hospitals Cleveland Medical Center
2016
Wright State University
1996-2013
Apple (United States)
2009-2013
Abstract Intestinal dysbiosis has been observed in children with cystic fibrosis (CF), yet the functional consequences are poorly understood. We investigated capacity of intestinal microbiota and inflammation CF. Stool samples were collected from 27 CF age gender matched healthy controls (HC) (aged 0.8–18 years). Microbial communities by iTag sequencing 16S rRNA genes profiles predicted using Tax4Fun. Inflammation was measured faecal calprotectin M2-pyruvate kinase. Paediatric...
Adult acquired flatfoot is a complex deformity with numerous radiographic measurements described to define it. The purpose of this study was evaluate the inter- and intraobserver reliability six using digital conventional radiographs.Three weightbearing radiographs consisting anteroposterior, lateral, hindfoot alignment views were obtained at presentation for 20 consecutive patients. Six made each patient: talus/second metatarsal angle, calcaneal pitch talus/first medial cuneiform/fifth...
Pediatric pancreatitis remains poorly understood despite increasing incidence and risk of morbidity mortality. Present predictive scores for severe pediatric acute (AP) are either extrapolated from adults or difficult to use in practice. We aimed identify laboratory parameters early prediction severity the course AP.A retrospective review children with AP (January 2000-July 2011) was performed at 2 hospitals. Predictors using measured within 24 hours presentation were derived cohort one...
Cystic fibrosis (CF) patients experience higher risks of colorectal cancer, but pathogenesis is unclear. In the general population, polyketide synthase-positive (pks+) E. coli impli-cated in intestinal carcinogenesis via production colibactin, however relevance CF unknown. We investigated pks+ prevalence at baseline and longitudinally, performing PCR on stool DNA extracts. Potential associations between gastrointestinal inflammation or microbiome dynamics were analysed using faecal...
Cystic fibrosis (CF) patients experience higher risks of colorectal cancer but the pathogenesis is unclear. In general population, polyketide synthase-positive (pks+) E. coli implicated in intestinal carcinogenesis via production colibactin; however, relevance CF unknown. this study, we investigate pks+E. prevalence and potential associations between coli, gastrointestinal inflammation, microbiome dynamics with fecal calprotectin 16SrRNA gene taxonomic data. Cross-sectional analysis...
Cystic fibrosis (CF) is a multisystem, autosomal, recessive disease primarily affecting the lungs, pancreas, gastrointestinal tract, and liver. Whilst there increasing evidence of microbial 'gut-lung axis' in chronic respiratory conditions, has been limited analysis such concept CF. We performed comprehensive dietary microbiota to explore interactions between diet, microbiota, clinical outcomes children with Our results demonstrate significant alterations intestinal inflammation when...
Simulation-based technologies are emerging to enhance medical education in the digital era. However, there is limited data for use of virtual reality simulation pediatric education. We developed Virtual Doc as a highly immersive teach cardiopulmonary resuscitation skills students.The primary objectives this study were evaluate participant satisfaction and perceived educational efficacy Doc. The secondary aim was assess game play features Doc.We conducted prospective closed beta-testing at...
Bariatric surgery is an effective method for acute weight loss. While the impact of bariatric on general medical conditions (e.g., type 2 diabetes) well documented, few studies focus physical functional outcomes following weight-loss induced by surgery.We report 50 women aged 20-74 scheduled Roux-en-Y gastric bypass (RYGB) procedure who were enrolled a prospective 1-year study. Height, weight, and waist circumference recorded preoperatively at 6 12 months, postoperatively. To track...
ABSTRACT Background: Cystic fibrosis‐related liver disease (CFLD) is the leading nonpulmonary cause of mortality in cystic fibrosis (CF). We evaluated and compared burden nonrespiratory comorbidities those with severe CFLD without (noCFLD). Methods: A retrospective nationwide (Australia) longitudinal review (from 1998 to 2016) patients noCFLD controls (matched 1 : for age, genotype, pancreatic insufficiency, center). Results: One hundred sixty‐six 166 were identified. Forced expiratory...
Madelung's deformity is a well-known congenital anomaly of the wrist. A number procedures have been described to correct and thus improve function at Most these large extent addressed alignment consequent radiocarpal joint but not persistent problem painful stiffness distal radioulnar (DRUJ). The availability total DRUJ prosthesis appears provide solution this problem. This article discusses our early experience with arthroplasty using Scheker for managing pain decreased range motion in...
Objective Acute biliary pancreatitis (ABP) is a common cause of which may require timely intervention. We aimed to identify routine laboratory parameters for early prediction aetiology in paediatric acute (AP). Design A retrospective review children with AP (January 2000–July 2011) was performed at two tertiary hospitals New South Wales, Australia. Predictors ABP using (measured within 48 h presentation) were determined multivariate logistic regression model and evaluated. Results Of the 131...
We analyzed all hand and wrist ganglions in patients aged 12 years younger that were treated at our institution during a 3-year period. Our predominately female (1.8:1). Volar more common (1.2:1), whereas dorsal have been reported to be adults. Ganglions had higher incidence of arising from tendon sheaths (33%) compared what has previously for studies age groups (5% 16%). While observation and/or splinting alone will likely helpful resolution majority pediatric ganglions, surgical excision...
Intestinal bacterial dysbiosis is evident in children with cystic fibrosis (CF) and intestinal viruses may be contributory, given their influence on species diversity biochemical cycles. We performed a prospective, case-control study CF age gender matched healthy controls (HC), to investigate the composition function of viral communities. Stool samples were enriched for DNA RNA by extraction, random amplification purification before sequencing (Illumina MiSeq). Taxonomic assignment was using...
Purpose Serious games (SGs) have great potential for pediatric medical education. This study evaluated the efficacy of a SG in improving learner satisfaction, knowledge, and behavior.