Yinchen Wuling powder is often used to treat clinical hyperlipidemia, although its mechanism of action remains unclear. In this study, we aimed investigate the active ingredients found in and find when treating using a combination network pharmacology, molecular docking, dynamics simulation approaches.The TCMSP database was obtain principle NCBI DisGeNet databases were main target genes involved intersectional targets obtained by EXCEL. We also Cytoscape 3.7.2 software construct "Traditional...

As the damage of gearbox wind turbines(WTs) will cause economic losses, it is necessary to conduct online condition monitoring(CM) on gearbox. Most WTs are equipped with SCADA system, and CM method based Supervisory Control Data Acquisition (SCADA) data one most economical methods. K Nearest Neighbor(KNN) algorithm has good robustness, typical nonlinear objects. Based this, KNN regression model established for CM, Distance Correlation (DC) coefficient used select modeling variables improve...

The potential role of the gut microbiome (GM) in heart failure (HF) had recently been revealed. However, underlying mechanisms GM and fecal metabolome HF have not characterized. Dahl salt-sensitive rat model hypertensive (H-HF) was used to study clinical symptoms characteristics. To elucidate pathogenesis HF, we combined 16S rRNA gene sequencing metabolomics analyze microbial compositions metabolomic profiles rats with H-HF.PCoA beta diversity shown that composition among three groups were...

Heart failure (HF) is a chronic condition that progressively worsens and continues to be major financial burden public health concern. The “gut-heart” axis provides an innovative perspective therapeutic strategy for preventing treating heart failure. Shenfu injection (SFI) Traditional Chinese Medicine-based treatment demonstrating potential as However, the precise mechanisms of SFI in are not completely characterized. In this study, HF models were established utilizing subcutaneous...

Aim Clarify the potential diagnostic value of tongue images for coronary artery disease (CAD), develop a CAD model that enhances performance by incorporating image inputs, and provide more reliable evidence clinical diagnosis CAD, offering new biological characterization evidence. Methods We recruited 684 patients from four hospitals in China cross-sectional study, collecting their baseline information standardized to train validate our algorithm. used DeepLabV3 + segmentation body employed...

To investigate the relationship between heart failure (HF) and gut microbiota-mediated energy metabolism, to explore role of Shenfu Injection in this process. In study, Adriamycin-induced chronic (CHF) rat model was used randomly divided into blank control group (Normal, n = 9), HF (Model, 12), treatment (SFI, positive drug (TMZ, 9). The changes microbiota structure were analyzed by 16S rRNA high-throughput sequencing, content short-chain fatty acids (SCFAs) detected targeted metabolomics...

Danxiong Tongmai Granules (DXTMG) are widely utilized in treating coronary heart disease (CHD) China. This study aims to explore the molecular mechanisms underlying therapeutic effects of DXTMG on CHD by employing a network pharmacology approach, complemented with experimental validation.

The upregulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) was reported to be involved in regulating the levels inflammatory markers and apoptosis macrophages. This study aims investigate function regulation PCSK9 myocardial ischaemia. results our showed dramatically increased expression induced by hypoxia/reoxygenation (H/R) stress rather than primary murine cardiomyocytes HL-1 cells. Moreover, promoted H/R-induced pro-inflammatory cytokine release from macrophages, while...

This study aimed to investigate the therapeutic effect of Shenfu Injection on mice with chronic heart failure(CHF) and its macrophage polarization. C57BL/6J were randomly assigned normal model groups. The CHF was established by intraperitoneal injection isoproterenol(ISO, 7.5 mg·kg~(-1), 28 d). successful modeling determined asses-sing cardiac function N-terminal pro-brain natriuretic peptide(NT-proBNP). modeled divided into group, TAK-242 injected intraperitoneally corresponding drugs for...

Sini Decoction (SND), a classic Chinese medicine prescription, has been proved to have good effect on heart failure (HF), whereas its underlying mechanism is still unclear. In order explore the therapeutic of SND, we combined with 16S rRNA gene sequencing analyze composition gut microflora in rats HF.Twenty Sprague-Dawley (SD) were divided into four groups (n = 5): normal group, model SND treatment group (SNT group), and metoprolol (Met) (Meto group). All except intraperitoneally injected...

<b><i>Objective:</i></b> Accumulated evidence suggests that ATP-binding cassette A1 transporter (ABCA1) contributes to secreting insulin in pancreatic β-cells and amyloid beta formation. This study aimed investigate the association between three single nucleotide polymorphisms (SNPs) of ABCA1 susceptibility type 2 diabetes mellitus (T2DM) a Han Chinese population. <b><i>Methods:</i></b> A total 996 T2DM patients 1,002 controls were included study. Three SNPs <i>ABCA1</i> gene, i.e.,...

Heart failure (HF) is an epidemic disease affecting a large population worldwide. Traditional Chinese medicine (TCM) playing increasingly important role in the clinical treatment of HF. According to TCM theory, HF could be classified into Yang deficiency and Qi-yin deficiency; however, there are few objective biological lines evidence for differentiation syndromes date. In this study, data-independent acquisition (DIA) mass spectrometry was applied comparatively analyze protein expression...

Digital Chinese medicine (DCM) is an emerging interdisciplinary field developed from traditional (TCM) and information science. In this article, we consider the significance propose architecture for DCM research, highlight key tasks that need to be performed provide references integration of science into research.

This study investigated the mechanisms and targets of Shenfu Injection in intervention chronic heart failure(CHF) through NOD-like receptor thermal protein domain associated 3(NLRP3)/caspase-1 signaling pathway. A CHF model was induced rats by subcutaneous injection isoproterenol. Model were randomly divided into a group, MCC950(NLRP3 inhibitor) blank group also set up as control. After 15 days treatment, echocardiography performed to measure cardiac function parameters [left ventricular...

Stereotactic body radiation therapy (SBRT) is effective for the treatment of cancer. Neutrophil‑to‑lymphocyte ratio (NLR) a common prognostic factor in predicting survival patients with Previous studies have reported that NLR may be able to predict cancer treated SBRT; however, results are inconsistent. Therefore, present study performed meta‑analysis pool data prediction using who underwent SBRT. PubMed, Google Scholar, Embase and The Cochrane Library were used search articles published...

The study aimed to explore the mechanism and targets of Shenfu Injection in regulation inflammatory injury chronic heart failure rats based on high mobility group box-1/Toll like receptor 4/nuclear factor kappa-B(HMGB1/TLR4/NF-κB) signaling pathway. rat model was established using isoproterenol. modeled were divided into three groups by random number table: group, glycopyrrolate normal also set. administrated for 15 consecutive days, following day after last administration, they sacrificed...

Chronic heart failure(CHF) is a severe cardiovascular disease characterized by complex pathogenesis involving myocardial structural and functional abnormalities the activation of inflammatory responses. The NOD-like receptor thermal protein domain-associated 3(NLRP3) inflammasome, acting as sensor for cells, plays pivotal role in development CHF. Research indicates that NLRP3 inflammasome can induce responses, leading to cardiac inflammation impairing function, it correlated with severity...

Background Heart failure (HF) is characterized by reduced ventricular filling or ejection function due to organic non-organic cardiovascular diseases. Danhong injection (DHI) a medicinal material used clinically treat HF for many years in China. Although prior research has shown that can improve cardiac and structure, the biological mechanism yet be determined. Methods Serum metabolic analysis was conducted via ultra-high-performance liquid chromatography-quadrupole time-of-flight/mass...

Chronic heart failure is the end stage of diseases caused by multiple causes. Myocardial cell injury key cause cardiac function deterioration. Ferroptosis, an iron-dependent programmed death mode, characterized iron overload and excessive accumulation lipid peroxides. Studies have demonstrated that inhibiting ferroptosis has a protective effect on myocardial cells. The theory &quot;harmful hyperactivity responding inhibition&quot; important rule developed physicians to explain generation...