A5003591370- Respiratory viral infections research
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- COVID-19 Pandemic Impacts
- interferon and immune responses
- Economic, Social, and Public Health Issues in Russia and Globally
- SARS-CoV-2 and COVID-19 Research
Institute for Biological Sciences
2019
Despite mass immunization against COVID-19, due to the high rate of spread, as well tendency rapidly change and recombine, SARS-CoV-2 virus caused several outbreaks (waves) disease around world. Thus, at end 2020, WHO announced emergence new variants SARS-CoV-2, which were associated with a wave COVID-19 cases. And beginning 2021, sequences B.1.1.7 variant, first identified in United Kingdom (UK) 2020 later called Alpha registered countries. In this regard, Kazakhstan, like other countries,...
The 2018/2019 influenza season in the WHO European Region was dominated by A (H1N1)pdm09 and (H3N2) viruses, with very few B viruses detected. Countries reported virus characterization data to Surveillance System for weeks 40/2018 20/2019. These antigenic genetic haemagglutinin (HA) sequence were analysed describe assess circulating relative vaccine components northern hemisphere. Thirty countries 4776 characterized genetically 3311 antigenically. All A(H1N1)pdm09 fell subclade 6B.1A, of...
The producers of influenza vaccines are not capable today to meet the global demand for an vaccine in case pandemic, so World Health Organization recommends develop own production each country. A domestic preservative- and adjuvant-free trivalent split against seasonal was developed at Research Institute Biological Safety Problems. paper presents results assessing safety immunogenicity after single immunization healthy volunteers aged 18-50 years course Phase I Clinical Trials. This study...
The paper describes the results of preclinical testing preparation "Vaccine allantoic split-virus inactivated against seasonal influenza." Acute toxicity and local irritating effect, anaphylactic reactions to different antigens (vaccine ovalbumin), delayed-type hypersensitivity ram erythrocytes, humoral immune response in hemaggtination reaction, immunogenic activity was studied laboratory animals various species (mice, rats, guinea pigs). Comparative analysis from under study commercial...