A5060714175- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neuroscience of respiration and sleep
- Evolutionary Psychology and Human Behavior
- Attachment and Relationship Dynamics
- Human-Animal Interaction Studies
- Animal Behavior and Welfare Studies
- Infant Health and Development
- Olfactory and Sensory Function Studies
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Hypothalamic control of reproductive hormones
- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Neural dynamics and brain function
- Diversity and Impact of Dance
- Cancer, Stress, Anesthesia, and Immune Response
- Menopause: Health Impacts and Treatments
- Animal Vocal Communication and Behavior
- Veterinary Practice and Education Studies
- Flow Experience in Various Fields
- Adipose Tissue and Metabolism
- Advanced Chemical Sensor Technologies
- Memory and Neural Mechanisms
Northeastern University
2014-2023
University of Veterinary Medicine Vienna
2019-2023
University of Illinois Chicago
2010-2020
University of Oslo
2020
Massachusetts General Hospital
2020
Harvard University
2020
University of Virginia
2020
Indiana University Bloomington
2016-2020
University of Arizona
2020
Mount Sinai Hospital
2020
Paternal behaviour and pair‐bond formation are defining characteristics of social monogamy. However, in comparison to pair‐bonding, the endocrine factors associated with male care young not well studied. In present study, plasma concentrations oxytocin, vasopressin corticosterone (CORT) were measured reproductively naïve prairie voles as a function exposure an infant or control manipulations (i.e. handling wooden dowel). Plasma oxytocin transiently elevated within 10 min pup exposure....
Positive welfare and related terms such as good welfare, happiness, a life are increasingly used in the animal science literature. Overall, they highlight benefits of providing animals opportunities for positive experiences, beyond alleviation suffering. However, various remain loosely defined sometimes interchangeably, resulting discrepancy. In this perspective article, we lay out concepts We identify two distinct views: "hedonic welfare," arising from likes wants their outcomes on welfare;...
Oxytocin is used in approximately half of all births the United States during labor induction and/or augmentation. However, effects maternal oxytocin administration on offspring development have not been fully characterized. Here, we socially monogamous prairie vole to examine hypothesis that exposure at birth can long-term developmental consequences. Maternally administered increased methylation receptor (Oxtr) fetal brain. As adults, oxytocin-exposed voles were more gregarious, with...
Although the detrimental physical health effects of social isolation have been known for three decades, answers to how and why relationships generally improve remain elusive. Social are not always beneficial, we examined a structural dimension that may bring about their salubrious effects: affiliative reciprocity during stressor.In lifespan study, female rats lived with sisters were tested temperament, an everyday stressor at puberty, corticosterone response stressor, mammary tumor...
A growing body of literature has suggested that intranasal oxytocin (OT) or other systemic routes administration can alter prosocial behavior, presumably by directly activating OT sensitive neural circuits in the brain. Yet there is no clear evidence given peripherally cross blood-brain-barrier at levels sufficient to engage receptor. To address this issue we examined changes blood oxygen level dependent (BOLD) signal intensity response peripheral injections (0.1, 0.5 2.5 mg/kg) during...
Blood oxygen level dependent (BOLD) imaging in awake mice was used to identify differences brain activity between wild-type, HETzQ175, and HOMzQ175 genotypes response the odor of almond. The study designed see how alterations huntingtin gene a mouse model Huntington's disease would affect perception processing almond odor, an evolutionarily conserved stimulus with high emotional motivational valence. Moreover, this were "odor naïve," i.e., never having smelled or any nuts. Using segmented,...
Social factors play a critical role in panoply of health processes, including, as recently demonstrated, olfaction. Here, we investigated sex-dependent differences the relationship between social lives and ability to identify odors large sample nationally representative older US adults (n = 3005, National Life Aging Project (NSHAP)). life was measured by number friends close relatives well frequency socializing. We here confirm association olfactory function extend notion showing...
Abstract Anxiety and social deficits, often involving communication impairment, are fundamental clinical features of fragile X syndrome. There is growing evidence that dysregulation in reward processing a contributing factor to the deficits observed many psychiatric disorders. Hence, we hypothesized transgenic mental retardation 1 gene ( fmr1 ) KO (FX) rats would display alterations processing. To this end, awake control FX were imaged for changes blood oxygen level dependent (BOLD) signal...
The advancement of neuroscience depends on continued improvement in methods and models. Here, we present novel techniques for the use awake functional magnetic resonance imaging (fMRI) prairie vole (Microtus ochrogaster) — an important step forward minimally-invasive measurement neural activity a non-traditional animal model. Imaging responses voles, species studied its propensity to form strong selective social bonds, is expected greatly advance our mechanistic understanding complex...
Blood oxygen level dependent (BOLD) imaging in awake mice was used to identify differences brain activity between wild-type, and Mu (µ) opioid receptor knock-outs (MuKO) response oxycodone (OXY). Using a segmented, annotated MRI mouse atlas computational analysis, patterns of integrated positive negative BOLD were identified across 122 areas. The pattern showed enhanced activation the WT within 15 min intraperitoneal administration 2.5 mg OXY. detected 72 regions out 122, most prominent...
In the present study, we used functional MRI in awake rats to investigate pain response that accompanies intradermal injection of capsaicin into hindpaw. To this end, BOLD imaging together with a 3D segmented, annotated rat atlas and computational analysis identify integrated neural circuits involved capsaicin-induced pain. The specificity was tested transgenic model contains biallelic deletion gene encoding for transient receptor potential cation channel subfamily V member 1 (TRPV1)....
Caregiving by nonparents (alloparenting) and fathers is a defining aspect of human social behavior, yet this phenomenon rare among mammals. Male prairie voles (Microtus ochrogaster) spontaneously exhibit high levels alloparental care, even in the absence reproductive experience. In previous studies, exposure to pup was selectively associated with increased activity oxytocin vasopressin neurons along decreased plasma corticosterone. present study, physiological, pharmacological...