A5047791093- Bioinformatics and Genomic Networks
- Breast Cancer Treatment Studies
- Liver Disease Diagnosis and Treatment
- Gene expression and cancer classification
- ATP Synthase and ATPases Research
- HER2/EGFR in Cancer Research
- Liver Diseases and Immunity
- BRCA gene mutations in cancer
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- Cancer Treatment and Pharmacology
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Breast Lesions and Carcinomas
- Protein Tyrosine Phosphatases
- Cancer Genomics and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Hidradenitis Suppurativa and Treatments
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- Diverticular Disease and Complications
- Hepatocellular Carcinoma Treatment and Prognosis
- Nutrition, Genetics, and Disease
- Pediatric Hepatobiliary Diseases and Treatments
- Renal and related cancers
Ben-Gurion University of the Negev
2008-2024
Soroka Medical Center
2004-2024
Clalit Health Services
2013
University of Chicago
2007-2009
In a life span study, we examined how the social environment regulates naturally occurring tumor development and malignancy in genetically prone Sprague–Dawley rats. We randomly assigned this gregarious species to live either alone or groups of five female Mammary burden among isolates increased 84 times that age-matched controls, as did malignancy, specifically 3.3 relative risk for ductal carcinoma situ invasive carcinoma, most common early breast cancers women. Importantly, isolation not...
Clinical studies have revealed that social support improves the outcome of cancer patients, whereas epidemiologic suggest isolation increases risk death associated with several chronic diseases. However, precise molecular consequences an unfavorable environment not been defined. To do so, robust, reproducible preclinical models are needed to study mechanisms whereby adverse affects gene expression and biology. Because random assignment inbred laboratory mice well-defined environments allows...
In this study we aimed to assess the incidence, prevalence and clinical outcomes of patients with autoimmune hepatitis (AIH) in southern Israel.Case-finding methods population-based administrative data were used evaluate epidemiology prognostic factors AIH from 1995 2010.During period, average annual incidence Israel 11.0/100000 0.67/100000, respectively. We identified 100 cases a mean age 47.9 years, including 95 women five men. Type 1 was found 77 cases, liver fibrosis cirrhosis 73.4%...
Cyclins D1, D2 and D3 play important roles in cell proliferation differentiation. Although their abnormal expression has been linked to cancer development progression a number of tissues, the cyclin proteins colon not yet characterised. In this study, we examined protein by Western blot analysis tumour adjacent normal tissues 57 patients. addition, D-type cyclins HT29 LoVo39 lines from carcinomas, as function induced both lines, three increased result proliferation, whereas tumours, D1 was...
Although the detrimental physical health effects of social isolation have been known for three decades, answers to how and why relationships generally improve remain elusive. Social are not always beneficial, we examined a structural dimension that may bring about their salubrious effects: affiliative reciprocity during stressor.In lifespan study, female rats lived with sisters were tested temperament, an everyday stressor at puberty, corticosterone response stressor, mammary tumor...
To prevent chemotherapy-related side effects, synthetic glucocorticoids, for example, dexamethasone, are routinely administered to patients with ovarian cancer. However, preclinical data implicate glucocorticoids in suppressing chemotherapy-mediated apoptosis epithelial tumors. The anti-apoptotic mechanisms underlying this increased survival have been shown require up-regulation of prosurvival genes, including serum and glucocorticoid-regulated kinase 1 (SGK1) map phosphatase (MKP1)/dual...
In recent years the frequency of nonsmokers among lung cancer patients has increased to 10% 15%. The measles virus rarely been evoked as an etiological agent in malignant tumors and its role carcinogenesis remains doubtful. It suggested that phosphoprotein may inhibit ubiquitination Pirh2, which reported be overexpressed carcinoma is responsible for degrading cell cycle regulator p53. authors conducted a clinicopathological study newly diagnosed with non-small all stages seen 10-year period....
Abstract Background We have been studying the native humoral immune response to cancer and isolated a library of fully human autoantibodies variety malignancies. previously described isolation characterization two monoclonal antibodies, 27.F7 27.B1, from breast patients that target protein known as GIPC1, an accessory PDZ-domain binding involved in regulation G-protein signaling. Human GIPC1 demonstrate specific malignant tissue with no reactivity normal tissue. Methods The current study...
The diagnosis of uterine smooth muscle tumors is sometimes difficult, as these may show worrisome features, suspicious for but not diagnostic malignancy. recommended immunohistochemical panel in this setting currently under debate. In study, we aimed to find a stains that would be helpful determining the correct ambiguous tumors, with an emphasis on investigating possible usefulness WT1 antibody. Uterine leiomyomas were found immunoreactive WT1. Since previous study reported lack...
We present the clinicopathologic features and treatment plans of 328 consecutive stage I (T1N0M0) breast cancer patients seen at a regional medical center in Israel. Predicted 10-year mortality risk was calculated using Adjuvant! Online website. The 21-gene recurrence score (RS) (OncotypeDx) obtained on minority patients. Eighty-nine per cent had estrogen receptor (ER) and/or progesterone (PgR) positive tumors. In 43.3% history an invasive malignancy reported first degree relative 15.5%...
Epithelioid hemangioendothelioma is a rare low- to intermediate-grade malignant vascular neoplasm with variable clinical course and currently no standardized treatment. We present case of 65-year-old woman diagnosed as having mediastinal epithelioid hemangioendothelioma, location which very exceptional. FDG PET/CT was more sensitive than CT for staging, revealing intense uptake in the primary tumor metastatic disease. Despite high uptake, disease stable further specific Only few reports...
Abstract Background Patients with primary hyperparathyroidism (PHPT) treated surgically occasionally have normalized calcium, but persistently high parathyroid hormone (PTH). We hypothesized that a possible explanation for this phenomenon is an underlying hyperplasia rather than adenoma. Methods Retrospective cohort of patients who underwent parathyroidectomy PHPT biopsy normal‐appearing gland were included. Cellularity level each and the adenoma's rim was determined. Results Forty‐seven Of...
<b><i>Objective:</i></b> To analyze the implementation of a switching policy adjuvant aromatase inhibitor (AI) therapy sequentially after tamoxifen in consecutively treated stage I (T1N0M0) hormone receptor (HR)-positive breast cancer (BC) patients. <b><i>Methods:</i></b> The records 279 consecutive HR-positive BC patients diagnosed between 2002 and 2006 followed at Soroka Medical Center were reviewed....
This study aimed to evaluate the long-term outcomes of stage I breast cancer (BC) patients diagnosed during current era screening mammography, immunohistochemistry receptor testing, and systemic adjuvant therapy.