Gregory F. Lewis

ORCID: 0000-0002-2548-8423
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About
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Research Areas
  • Heart Rate Variability and Autonomic Control
  • Infant Health and Development
  • Neuroendocrine regulation and behavior
  • Non-Invasive Vital Sign Monitoring
  • Stress Responses and Cortisol
  • Neuroscience of respiration and sleep
  • Vagus Nerve Stimulation Research
  • Resilience and Mental Health
  • Cardiovascular Syncope and Autonomic Disorders
  • Psychosomatic Disorders and Their Treatments
  • Respiratory and Cough-Related Research
  • Animal Vocal Communication and Behavior
  • Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Posttraumatic Stress Disorder Research
  • Behavioral and Psychological Studies
  • Cardiac Arrest and Resuscitation
  • EEG and Brain-Computer Interfaces
  • Child and Adolescent Psychosocial and Emotional Development
  • Autism Spectrum Disorder Research
  • Mental Health Research Topics
  • Cardiovascular and exercise physiology
  • Cardiac Health and Mental Health
  • Thermoregulation and physiological responses
  • Traumatic Brain Injury Research
  • Language Development and Disorders

Indiana University Bloomington
2017-2025

Indiana University
2018-2024

Lewis University
2023

Ten Chen Hospital
2023

Shiraz University
2021

Penn State Milton S. Hershey Medical Center
2017-2020

University of North Carolina at Chapel Hill
2014-2018

RTI International
2012-2017

University of Illinois Chicago
2008-2014

Abstract Preterm infants have maturational delays in several neurobehavioral systems. This study assesses the impact of Family Nurture Intervention (FNI) neonatal intensive care unit (NICU) on maturation autonomic regulation preterm infants. born at 26–34 weeks postmenstrual age (PMA) were assigned to groups receiving either standard (SC) or SC plus FNI, using a randomized controlled trial design. At two collection time points, approximately 35 and 41 PMA, electrocardiograms (ECG) monitored...

10.1002/dev.21841 article EN Developmental Psychobiology 2019-03-13

Posttraumatic stress disorder (PTSD) is a reaction to trauma that results in chronic perception of threat, precipitating mobilization the autonomic nervous system, and may be reflected by disinhibition limbic structures. A common injury preceding PTSD veterans mild traumatic brain (mTBI). This due vulnerability white matter these networks such damage affect treatment response. We evaluated transcutaneous vagal nerve stimulation (tVNS), non-invasive, low-risk approach alter functions...

10.3389/fmed.2017.00124 article EN cc-by Frontiers in Medicine 2017-07-31

Abstract In psychophysiological research, measurement of respiration has been dependent on transducers having direct contact with the participant. The current study provides empirical data demonstrating that a noncontact technology, infrared video thermography, can accurately estimate breathing rate and relative tidal volume across range patterns. Video tracking algorithms were applied to frame‐by‐frame thermal images face extract time series nostril temperature generate breath‐by‐breath...

10.1111/j.1469-8986.2010.01167.x article EN Psychophysiology 2011-01-07

Abstract Decreased heart rate variability (HRV) is associated with posttraumatic stress disorder (PTSD) and depression symptoms, but PTSD's effects on the autonomic response potential influence of HRV biofeedback in relaxation training improving PTSD symptoms are not well understood. The objective this study was to examine impact a predeployment inoculation (PRESTINT) protocol physiologic measures large sample military population randomly assigned experimental biofeedback‐assisted versus...

10.1111/psyp.12455 article EN Psychophysiology 2015-06-11

The objective of this pilot study was to design, develop, and evaluate a predeployment stress inoculation training (PRESIT) preventive intervention enable deploying personnel cope better with combat-related stressors mitigate the negative effects trauma exposure. PRESIT program consisted three modules: (1) educational materials on combat operational control, (2) coping skills involving focused relaxation breathing exercises biofeedback, (3) exposure video multimedia stressor environment...

10.7205/milmed-d-15-00192 article EN Military Medicine 2016-09-01

INTRODUCTION: To determine whether pretreatment vagal efficiency (VE), respiratory sinus arrhythmia, and heart period can predict pain improvement with auricular neurostimulation in pediatric functional abdominal disorders. METHODS: A total of 92 adolescents disorders underwent a 4-week randomized, double-blinded, sham-controlled trial. Electrocardiogram-derived variables at baseline were used to using mixed effects modeling. RESULTS: 3-way interaction (95% confidence intervals: 0.004–0.494)...

10.14309/ajg.0000000000000753 article EN The American Journal of Gastroenterology 2020-07-23

INTRODUCTION: The pathophysiology underlying cyclic vomiting syndrome (CVS) remains undefined. Scant data and distinct clinical features point to altered autonomic nervous system function. Autonomic signaling can be noninvasively assessed through cardiac indices of parasympathetic vagal regulation, which is reduced in children with disorders gut-brain interaction. We aimed examine dynamic regulation CVS compared that healthy controls (HC). METHODS: A total 31 evaluated a tertiary care center...

10.14309/ajg.0000000000002207 article EN The American Journal of Gastroenterology 2023-01-30

Heart rate variability (HRV) is a reliable indicator of health status and sensitive index autonomic stress reactivity. Stress negatively affects physical psychological wellness by decreasing cardiovascular reducing quality life. Wearable sensors have made it possible to track HRV during daily activity, recent advances in mobile technology reduced the cost difficulty applying this powerful technique. Although smaller lighter, some burden on subject remains. Chest-worn electrocardiogram (ECG)...

10.3389/fpubh.2017.00300 article EN cc-by Frontiers in Public Health 2017-11-21

<bold>Background:</bold> The spread of the COVID-19 virus presents an unprecedented event that rapidly introduced widespread life threat, economic destabilization, and social isolation. human nervous system is tuned to detect safety danger, integrating body brain responses via autonomic system. Shifts in brain-body states toward danger can compromise mental health. For those who have experienced prior potentially traumatic events, threat response may be sensitive new dangers these mediate...

10.3389/fpsyt.2020.577728 article EN cc-by Frontiers in Psychiatry 2020-10-27

ABSTRACT Objectives Percutaneous electrical nerve field stimulation (PENFS) is an effective treatment for disorders of gut–brain interaction (DGBI), proposed to influence vagal pathways. Cardiac metrics such as respiratory sinus arrythmia (RSA) and efficiency (VE) can noninvasively assess parasympathetic output. Commonly used antidepressant drugs inhibit signaling may interfere with PENFS. This study examined immediate effects active compared sham PENFS on cardiac function in adolescents...

10.1111/nmo.15007 article EN cc-by-nc-nd Neurogastroenterology & Motility 2025-01-30

Executive functions are a set of cognitive processes essential for control and coordination, enabling the achievement objectives. These include mental exploration ideas, reasoning, logical conclusion drawing, discipline, decision making, thoughtful consideration before action, tackling unforeseen challenges, resisting temptations, maintaining focus. Numerous neuropsychological tests assess executive in relation to different autonomic pathways that regulate involuntary physiological...

10.1101/2025.02.25.640212 preprint EN cc-by-nc bioRxiv (Cold Spring Harbor Laboratory) 2025-02-26

&lt;p dir="ltr"&gt;&lt;b&gt;Objective:&lt;/b&gt; To test the association of autonomic nervous system (ANS) dysregulation symptoms and diabetes distress (DD) in adults with type 1 (T1D; Study 1) 2 (T2D: 2)&lt;/p&gt;&lt;p dir="ltr"&gt;&lt;b&gt;Research Design Methods&lt;/b&gt;: 556 T1D 299 T2D completed Body Perception Questionnaire (BPQ) to assess ANS reactivity symptoms, (DDS-T1, DDS-17), anxiety (GAD-7), depression (PHQ-8) demographic variables via internet surveys.&lt;/p&gt;&lt;p...

10.2337/figshare.28498109 preprint EN cc-by-nc-sa 2025-03-31

&lt;p dir="ltr"&gt;&lt;b&gt;Objective:&lt;/b&gt; To test the association of autonomic nervous system (ANS) dysregulation symptoms and diabetes distress (DD) in adults with type 1 (T1D; Study 1) 2 (T2D: 2)&lt;/p&gt;&lt;p dir="ltr"&gt;&lt;b&gt;Research Design Methods&lt;/b&gt;: 556 T1D 299 T2D completed Body Perception Questionnaire (BPQ) to assess ANS reactivity symptoms, (DDS-T1, DDS-17), anxiety (GAD-7), depression (PHQ-8) demographic variables via internet surveys.&lt;/p&gt;&lt;p...

10.2337/figshare.28498109.v1 preprint EN cc-by-nc-sa 2025-03-31

To test the association of autonomic nervous system (ANS) dysregulation symptoms and diabetes distress (DD) in adults with type 1 (T1D; study 1) 2 (T2D; 2). A total 556 T1D 299 T2D completed Body Perception Questionnaire (BPQ) to assess ANS reactivity symptoms, (via Diabetes Distress Scale T1 [DDS-T1], DDS-17), anxiety General Anxiety Disorder 7 [GAD-7]) scale, depression Patient Health Questionnaire-8 [PHQ-8]), demographic variables via internet surveys. In 1, participants' mean age was...

10.2337/dc24-2614 article EN PubMed 2025-03-31

<sec> <title>BACKGROUND</title> Chronic stress and emotional cognitive regulation difficulties during early childhood are associated with risky behaviors negative outcomes later in life. As preschoolers still developing their skills, they often depend on external support to manage emotions behaviors. Intervening is essential for promoting healthy development preventing future challenges. Mindful Movement Practices (MMPs) – which incorporate physical activities, breathwork, reflective...

10.2196/preprints.75731 preprint EN 2025-04-09

Auditory hypersensitivities are a common feature of autism spectrum disorder (ASD). In the present study effectiveness novel intervention, Listening Project Protocol (LPP) was evaluated in two trials conducted with children diagnosed ASD. LPP developed to reduce auditory hypersensitivities. is based on theoretical "neural exercise" model that uses computer altered acoustic stimulation recruit neural regulation middle ear muscles. Features intervention stimuli were informed by basic research...

10.3389/fped.2014.00080 article EN cc-by Frontiers in Pediatrics 2014-08-01

Research suggests that lower respiratory sinus arrhythmia (RSA) is associated with greater aversive responding. One physiological indicator of responding startle potentiation. While a few studies have demonstrated an inverse association between RSA and potentiation, no study to date has distinguished whether this relation similar for predictable versus unpredictable stimuli. This important distinction, given degree predictability been shown be determinant The present examined resting was eye...

10.1027/0269-8803/a000091 article EN Journal of Psychophysiology 2013-01-01

Abstract Background Joint hypermobility (JH) is associated with autonomic nervous system dysregulation and functional abdominal pain disorders (FAPDs). Understanding the neurophysiological processes linking these conditions can inform clinical interventions. Autonomic activity regulates gastrointestinal (GI) sensorimotor function may be a key mechanism. The aims of this study were to examine relation JH dynamic parasympathetic regulation in adolescents FAPDs identify optimal cutoff scores...

10.1111/nmo.14165 article EN Neurogastroenterology & Motility 2021-05-15
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