A5003809525- Advanced ceramic materials synthesis
- Intermetallics and Advanced Alloy Properties
- Advanced materials and composites
- Aluminum Alloys Composites Properties
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Nuclear materials and radiation effects
- High-pressure geophysics and materials
- Advanced Nanomaterials in Catalysis
- Cancer-related gene regulation
- Hip disorders and treatments
- Lymphoma Diagnosis and Treatment
- Endometriosis Research and Treatment
- Catalytic Processes in Materials Science
- Viral-associated cancers and disorders
- Neuroblastoma Research and Treatments
- Circular RNAs in diseases
- Hip and Femur Fractures
- Neuroendocrine Tumor Research Advances
- Pelvic and Acetabular Injuries
- Lung Cancer Research Studies
- Pelvic floor disorders treatments
- CAR-T cell therapy research
- Nanoparticle-Based Drug Delivery
- Cancer-related molecular mechanisms research
Xiangya Hospital Central South University
2023-2025
Central South University
2023-2025
Southwest Medical University
2024
Sichuan University
2015-2023
West China Hospital of Sichuan University
2023
Approximately 80% of nasopharyngeal carcinoma (NPC) patients exhibit EGFR overexpression. The overexpression has been linked to its potential role in modulating major histocompatibility complex class I (MHC-I) molecules. We discovered that EGFR, operating a kinase-independent manner, played stabilizing the expression SLC7A11, which subsequently inhibited MHC-I antigen presentation. This mechanism, turn, provided protection NPC cells against T cell-mediated cytotoxicity. underlying molecular...
Abnormal lactate metabolism in tumor cells leads to immune escape the microenvironment. Intervening specific metabolic pathways while blocking downstream pyruvate influx holds great promise for overcoming conventional lactate‐targeted therapy limitations such as short half‐life, insufficient consumption, and pathological microenvironment elasticity. Herein, a nanocatalytic medicine based on carbondoping engineered copper nitride enzyme (Cu3N‐C NE) with enhanced oxidase (LOX) activity was...
Abstract Background A new classification system for acetabular fractures has been proposed in recent years, which is called the 3-column classification. However, this does not provide information regarding quadrilateral plate fractures. To address issue, we utilized three-dimensional (3D) fracture line mapping and heat map to analyze link between Methods We collected CT scan data from 177 patients who had diagnosed with Additionally, a of healthy adult generate standard model. create 3D...
Non-coding microRNAs (miRNAs), involved in post-transcriptional control, are widely the mechanism of cellular resistance to antitumor chemotherapy. Ectopic expression one these miRNAs, miRNA‑215 (miR‑215), leads chemoresistance by directly targeting dihydrofolate reductase (DHFR) and thymidylate synthase (TS), which two most important targets chemotherapeutic agents. This indicates possible upregulation endogenous miR‑215 process interfering with transcripts. In present study, was examined...
Nasopharyngeal carcinoma (NPC) is a particular type of tumor connected to Epstein-Barr virus infection, genetic, and environmental factors. It typically discovered late, with few therapeutic options poor clinical outcomes. Cellular immune responses can be attenuated when programmed death ligand 1 (PD-L1) cell protein (PD-1) are combined. Although PD-1 inhibitors have different anti-tumor response rate than chemotherapy alone, they nevertheless considerably outperform in patients metastatic...
The large-scale Al2O3/YSZ ceramic plates were prepared by combustion synthesis under high gravity, the ceramics mainly composed of random-oriented rod-shaped grains, and within grain aligned nano-submicron YSZ fibers embedded. Compared to high-performance directionally solidified ceramics, hardness, flexural strength fracture toughness eutectic obtained in experiment increased 40.7~55.1%, 9.6~26.0% 172.0~240.0%, respectively. increase hardness could be attributed inter-phase spacing...
The molecular mechanisms involved in the pathogenesis of pelvic organ prolapse (POP) remain unclear. This study aimed to identify key molecules and progression POP. Differentially expressed genes (DEGs) were identified based on gene expression data extracted from GSE53868, GSE28660, GSE12852 datasets omnibus database. R software was used for mining, ontology functional annotation Kyoto encyclopedia genomes enrichment analyses performed explore biological functions DEGs. A protein-protein...
Micro-nanocrystalline microstructures characterized by TiB 2 platelets of the average thickness close to or smaller than 1 μm, were achieved in full-density solidified TiC-TiB composites combustion synthesis high-gravity field. XRD, FESEM and EDS results showed that a large number fine uniformly embedded irregular TiC grains, few Cr-Al metallic phases between those phases. The achievement micro-nanocrystalline from low-velocity faceting growth crystal, high-velocity non-faceting solid high...
By adjusting mass fraction of Ni-Al composite additive in Ti-B 4 C primary system, a series TiB 2 -based ceramic composites were prepared by combustion synthesis high gravity field. Because the adiabatic temperature whole reaction system maintained constant presence smaller than 18.55%, increasing to be 15% brought about improved homogeneity refined microstructure enhanced-densification composite, so flexural strength and fracture toughness increased simultaneously due enhanced...
Based on preparing the large-bulk solidified Al2O3-ZrO2 (Y2O3) ceramic composites by combustion synthesis under high gravity, solidification behavior and microstructure transformation of ceramics as well their effects properties were investigated. XRD, SEM EDS analyses showed microstructures composed irregular eutectics at surface tetragonal ZrO2 micrometer spherical crystals in center respectively. By combining with irreversible nucleation theory, it is considered that formation...
By introducing ZrO2(4Y) powder of suitable content into the thermit and based on oxidation-reduction reaction liquid-liquid phase separation ceramics/metal under gravity, Al2O3/ZrO2(4Y) composite ceramics have been prepared through melt-growth with eutectic high degree undercooling from SHS process. It has found that were composed major rod-shaped sapphires 8.0~12.0 aspect ratios minor plate-like α-Al2O3 grains, within t-ZrO2 nano-micron fibers embedded. Flexural strength fracture toughness...
Al2O3-30vol%ZrO2 nano-submicron structured ceramics has been obtained from high-temperature melts produced by SHS metallurgical process, SEM images show that the multiphase is mainly composed of Al2O3 matrix eutecticums in which ZrO2 fibers are up to scale, resulting formation intra-granular structures. Vickers hardness test indicates critical value indentation load induces median crack extend 30kg, and morphologies indicate performed with high fracture toughness plasticity. Meanwhile,...