A5017104579- Medicinal Plant Research
- Primate Behavior and Ecology
- Alzheimer's disease research and treatments
- Animal Nutrition and Physiology
- Memory and Neural Mechanisms
- Malaria Research and Control
- Meat and Animal Product Quality
- Animal Behavior and Welfare Studies
- SARS-CoV-2 and COVID-19 Research
- Aquatic life and conservation
- Diverse Scientific Research Studies
- Probiotics and Fermented Foods
- Adipose Tissue and Metabolism
- Viral Infections and Vectors
- Dementia and Cognitive Impairment Research
- Animal Virus Infections Studies
- Diet and metabolism studies
- Mosquito-borne diseases and control
- Agricultural and Biological Research
- SARS-CoV-2 detection and testing
- Antibiotic Resistance in Bacteria
- Identification and Quantification in Food
- Phytochemical compounds biological activities
- Dengue and Mosquito Control Research
- Rabies epidemiology and control
IPB University
2013-2025
University of Copenhagen
2013-2014
Copenhagen University Hospital
2013
Farmak (Czechia)
2012
The metabolism cage is a barren, non-enriched, environment, combining number of recognized environmental stressors. We investigated the ability male BALB/c mice to acclimatize this form housing. For three weeks markers acute and oxidative stress, as well clinical signs abnormality were monitored. Forced swim tests conducted determine whether animals experienced behavioral despair serotonergic integrity was tested using an 8-OH-DPAT challenge. housed excreted approximately tenfold higher...
Phanera semibifida is a forest plant that contains metabolites such as flavonoids, terpenoids, saponins, and tannins. Lingga Malay ethnic uses P. stem the main ingredient in health potions. Based on this primary evidence, has potential medicinal uses. However, studies metabolite content bioactivity screening of leave extract are still limited. This research aimed to identify phytochemical profile stems leaf extract. The sample was extracted using 96% ethanol with maceration methods. chemical...
Background: Alzheimer's disease (AD) is characterized by the buildup and aggregation of misfolded proteins in brain, including amyloid-β (Aβ) hyperphosphorylated tau. The hyperphosphorylation state Tau protein plays an important role development AD. Our previous studies developed cynomolgus monkey as a spontaneous animal model Aim: We demonstrated validity through experimental investigations relationships between cognitive decline neuro-pathy There is, however, little information about...
Pseudomonas putida is a gram-negative, rod-shaped, flagellated bacterium that found in soil and water habitats where there oxygen. The bacteria was obtained through culture from organs swab of Cynomolgus monkey, Macaca fascicularis. This study aims to evaluate analyse the histological slides fascicularis including liver, kidneys, lungs, spleen are suspected infection,. most common lesion cell necrosis which can be seen liver samples. Another lungs kidneys congestion around cells, whereas...
Pathological hallmarks indicative of Alzheimer's disease (AD), which are the plaques amyloid beta1-42 and neurofibrillary tangles, were found in brain aged cynomolgus monkey. The aim this study was to investigate if monkeys exhibiting spatial memory impairment levels biomarkers AD, had lesions similar human patients suffering from senile dementia. Generating immunohistochemistry technique phosphorylated tau 231, our assessed amyloidopathy, such as cerebral angiopathy, tauopathy, possible...
Background and Aim: Asian macaques are natural hosts of several Plasmodium species. Some monkey malaria parasites may infect humans cause zoonotic infections. This study was conducted to estimate the prevalence in Bogor, Indonesia, based on molecular detection identification, particularly cynomolgus monkeys, which have a wide geographic distribution share extensive habitats with humans. These data needed evaluate status simian among Bogor potential risks human health. updated will provide...
Abstract Background In an attempt to explore cynomolgus monkeys as animal model for A lzheimer's disease, the present study focused on biomarkers beta amyloid 1–42 ( β 42 ) in serum, and total tau (t‐tau) phosphorylated (p‐tau) levels cerebrospinal fluid. Methods We measured biomarker Y oung ged correlated these with performance three delayed response tasks. Results The concentration of was significantly lower than subjects, while t‐tau p‐tau did not differ between groups. subjects performed...
Colistin is the last drug choice for dealing with carbapenem-resistant Enterobacteriaceae bacteria; hence, this very crucial to human health. The discovery of a plasmid-mediated colistin-resistant gene, mobilized colistin resistance-1 (mcr-1), signals significant global health threat. sulfate an antimicrobial agent which has been approved use in broilers Indonesia. Thus, study aimed measure prevalence E. coli and detect mcr-1 gene coli, O157:H7 entire supply chain Bogor Regency, West Java...
Abstract There is a critical need to generate age- and sex-specific survival curves characterize chronological aging consistently across nonhuman primates (NHP) used in biomedical research. Sex-specific Kaplan-Meier were computed 12 translational models: baboon, bonnet macaque, chimpanzee, common marmoset, coppery titi monkey, cotton-top tamarin, cynomolgus Japanese pigtail rhesus squirrel vervet/African green. After employing strict inclusion criteria, primary results are based on 12,269...
Malaria remains a significant global health burden, with drug resistance posing major challenge to its control. The emergence of antimalarial drugs represents critical issue in malaria management, as it heightens the likelihood morbidity and mortality associated disease. There is an urgent requirement for novel candidate distinct mechanism action.
Abstract. Elfita L, Wientarsih I, Sajuthi D, Bachtiar Darusman HS. 2020. The diversity in nutritional profile of farmed edible bird’s nests from several regions Indonesia. Biodiversitas 21: 2362-2368. Edible nest (EBN) is produced by certain swiftlet species mainly Aerodramus fuciphagus. This study aimed to compare the composition proximate, nitrite, nitrate, amino acid and protein profiles EBNs collected different Indonesia (West Sumatra, South West Java, Kalimantan, Central Sulawesi,...
Canine distemper virus (CDV) is recognized as a conservation threat to Amur tigers (Panthera tigris altaica) in Russia, but the risk other subspecies remains unknown. We detected CDV neutralizing antibodies nine of 21 wild-caught Sumatran (42.9%), including one sampled on day capture, confirming exposure wild.
Abstract Mosquito larvae play an essential role in the ecological, and many of them can spread human animal diseases, including Macaca fascicularis . Information on mosquito species their habitats provide overview mosquitoes vector-borne diseases M. captivity area. This study aimed to identify diversity larvae, affinity association, larval breeding sites around area Bogor, West Java. were collected from 102 using a 350 ml dipper. that successfully consisted 11 species; Aedes albopictus, Ae....
Cynomolgus monkeys (Macaca fascicularis) develop spontaneous infection of Papillomavirus (PV); thus, potentially beneficial for modeling human PV (HPV) study. Contrary to origin, in cynomolgus does not always show evident clinical symptoms cervical cancer. The absence cancer leads us investigate the molecular mechanism HPV monkeys. This study aimed messenger ribonucleic acid (mRNA) expression levels KI67 and P53 genes, majorly known as biomarker oncogenesis infection. polymerase chain...
Neurons with histopathological changes consistent granulovacuolar degeneration (GVD) were found in brain sections from aged cynomolgus monkeys (Macaca fascicularis) clinical and pathological signs of cognitive aging. To our knowledge, this is the first reported description GVD non-human primates. GVD-like lesions also age-matched cognitively healthy subjects, albeit lower numbers, suggesting that they may relate to aging increase have tendency memory deficits. The increased incidence...
The cynomolgus monkey (Macaca fascicularis) has shown promise as a spontaneous model of age-related dementias, such Alzheimer's Disease. Using series memory tests, we have found evidence that performance on delayed response tasks was age-related, with poorer being demonstrated by old monkeys (> 20 years age), compared to young (4-9 age) and middle-aged (10-16 individuals. Performance the correlated levels core biomarkers indicative Disease in circulation; particular amyloid-beta 1-42 (Aβ42)....
Abstract Previous studies of aging cynomolgus monkeys from our group identified spontaneous age‐associated cognitive declines associated with biomarkers and brain lesions reminiscent Alzheimer's Disease (AD), in a proportion aged monkeys. However, the molecular mechanisms that underlie amyloid disorders observed these affected have yet to be investigated detail. Using reverse transcriptase quantitative real time PCR techniques, normalized ACTB housekeeping gene, we analyzed expression...
Monyet ekor panjang (Macaca fascicularis) sering digunakan sebagai hewan model dalam penelitian biomedis. Nematodosis umum ditemukan pada kelompok primata yang bukan manusia atau non-human primate. gastrointestinal dapat memengaruhi hasil berpotensi sumber penularan ke (zoonosis). Penelitian bertujuan melakukan identifikasi tipe, menghitung tingkat kejadian dan derajat infeksi kecacingan nematoda monyet di kandang penangkaran Pusat Studi Satwa Primata, Lembaga Pengabdian kepada Masyarakat...