A5037004477- RNA Research and Splicing
- Neurogenetic and Muscular Disorders Research
- Angiogenesis and VEGF in Cancer
- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Amyotrophic Lateral Sclerosis Research
- Genetic Associations and Epidemiology
- Mitochondrial Function and Pathology
- Plant Molecular Biology Research
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Chromatin Dynamics
- Prion Diseases and Protein Misfolding
- Cancer-related gene regulation
- Genetic Neurodegenerative Diseases
- Signaling Pathways in Disease
- RNA regulation and disease
- Genetic and phenotypic traits in livestock
- NF-κB Signaling Pathways
Daegu Gyeongbuk Institute of Science and Technology
2018-2024
Kongju National University
2021-2023
ORCID
2021
Significance It remains unclear how the structural properties of polyglutamine (polyQ) proteins, which underlie several neurodegenerative disorders, including Huntington’s disease and spinocerebellar ataxias (SCAs), translate into toxicity these proteins. Here, we demonstrate that coiled-coil structures in expanded polyQ regions SCA type 3 (SCA3) proteins cause dendrite defects Drosophila neurons, as well behavioral abnormalities. Moreover, interactions SCA3 with Foxo mediated by domains two...
Constitutive photomorphogenic 1 (COP1), is an E3 ubiquitin ligase that plays a role in the regulation of various cellular processes including cell growth, differentiation, and survival mammals. In certain conditions such as overexpression or loss function, COP1 acts either oncogenic protein tumor suppressor by targeting specific proteins for ubiquitination-mediated degradation. However, precise has not been well studied primary articular chondrocytes. this study, we investigated chondrocyte...
Dendrite pathology is frequently observed in various neurodegenerative diseases (NDs). Although previous studies identified several pathogenic mediators of dendrite defects that act through loss function NDs, the underlying mechanisms remain largely unexplored. Here, our search for additional contributors to NDs identifies Relish/NF-κB as a novel gain-of-toxicity–based mediator animal models polyglutamine (polyQ) and amyotrophic lateral sclerosis (ALS). In Drosophila model polyQ diseases,...
Abstract RNA-binding proteins (RBPs) play essential roles in diverse cellular processes through post-transcriptional regulation of RNAs. The subcellular localization RBPs is thus under tight control, the breakdown which associated with aberrant cytoplasmic accumulation nuclear such as TDP-43 and FUS, well-known pathological markers for amyotrophic lateral sclerosis frontotemporal dementia (ALS/FTD). Here, we report Drosophila model ALS/FTD that a RBP Staufen may be new feature. We found C4da...
Amyotrophic lateral sclerosis is a devastating neurodegenerative disease with complex genetic basis, presenting both in familial and sporadic forms. The hexanucleotide (G
Abstract Accumulating evidence hints heterochromatin anchoring to the inner nuclear membrane as an upstream regulatory process of gene expression. Given that formation neural progenitor cell lineages and subsequent maintenance postmitotic neuronal identity critically rely on transcriptional regulation, it seems possible development cells is influenced by type-specific and/or context-dependent programmed regulation anchoring. Here, we explored this possibility genetically disrupting...
Abstract Chondrocyte dedifferentiation is a cellular phenomenon in which chondrocyte loses its chondrogenic characteristics and ability to synthesize extracellular matrix. These conditions commonly reported different cartilage degenerative diseases. The methods used induce cell models of chondrocytes are often time consuming or require expensive reagents. Here our protocol, we describe the utility using 2-deoxy-D-glucose as dedifferentiating agent for rabbit studying process.
Accumulating evidence hints heterochromatin anchoring to inner nuclear membrane as an upstream regulatory process of gene expression. Given that formation neural progenitor cell lineages and subsequent maintenance postmitotic neuronal identity critically rely on the transcriptional regulation, it seems possible development cells is influenced by type-specifically and/or context-dependently programmed control its status. Here, we explored this possibility genetically perturbing evolutionarily...